Urology News Archive

Overactive Bladder (OAB) FDA Approves Nocdurna for Nocturia Due to Nocturnal Polyuria

FDA Approves Nocdurna for Nocturia Due to Nocturnal Polyuria

Nocdurna carries a Boxed Warning for hyponatremia.

Prostate Cancer Enzalutamide Delays Metastasis in CRPC

Enzalutamide Delays Metastasis in CRPC

Men receiving enzalutamide plus ADT had a significant 71% lower risk for metastasis or death compared with men receiving placebo plus ADT.

Urinary Tract Infections (UTI) FDA Approves Drug for Complicated UTIs

FDA Approves Drug for Complicated UTIs

Plazomicin, an aminoglycoside, was approved for treating complicated urinary tract infections in adults due to certain Enterobacteriaceae.

Urology In Cancer Patients, PTSD May Increase Symptom Burden

In Cancer Patients, PTSD May Increase Symptom Burden

Post-traumatic stress symptoms also linked to lower risk of readmission in hospitalized CA patients.

Hypogonadism Testosterone Levels May Be Determined in Childhood

Testosterone Levels May Be Determined in Childhood

Children who migrated to the UK from Bangladesh before puberty and Bangladeshis born in the UK had significantly higher levels of testosterone compared with life-long residents of Bangladesh.

Kidney Cancer New Findings Support Ablation for Small Renal Tumors

New Findings Support Ablation for Small Renal Tumors

Percutaneous ablation offers cancer-related outcomes similar to those of radical nephrectomy but with a lower likelihood of long-term renal insufficiency and complications.

Erectile Dysfunction (ED) Effect of Shock Wave Treatment for Erectile Dysfunction Wanes

Effect of Shock Wave Treatment for Erectile Dysfunction Wanes

Only half of patients with initial treatment success maintain benefits at 2 years.

Bladder Cancer Robotic, Open Cystectomy Offer Comparable Bladder Cancer Outcomes

Robotic, Open Cystectomy Offer Comparable Bladder Cancer Outcomes

In a randomized study, patients who underwent robotic-assisted and open radical cystectomy had similar 2-year progression survival rates.

Prostate Cancer Prostate Cancer Vaccine Found Not to Improve Survival

Prostate Cancer Vaccine Found Not to Improve Survival

In a phase 3 trial, Prostvac-V/F did not significantly prolong overall survival among men with asymptomatic or minimally symptomatic mCRPC.

Bladder Cancer Gender Difference in Survival Seen After Radical Cystectomy

Gender Difference in Survival Seen After Radical Cystectomy

Females have worse disease-free, cancer-specific, overall survival versus males with bladder cancer.

Prostate Cancer End-of-Life Prostate Cancer-Related Complications Characterized

End-of-Life Prostate Cancer-Related Complications Characterized

Men with advanced prostate cancer at diagnosis have an elevated risk of spinal cord compression, renal failure, and other cancer-related morbidities.

Overactive Bladder (OAB) OAB, Nocturia Linked With Higher Fall Risk

OAB, Nocturia Linked With Higher Fall Risk

Treatment appeared to reduce fall risk among older adults.

Kidney Stones Tamsulosin Ineffective for Small Ureteral Stones

Tamsulosin Ineffective for Small Ureteral Stones

The passage rate for ureteral stones less than 9 mm in diameter did not differ significantly between tamsulosin and placebo recipients, study finds.

Overactive Bladder (OAB) Multiple Risk Factors Linked With Nocturia

Multiple Risk Factors Linked With Nocturia

Study confirms associations between nocturia and older age, female sex, overactive bladder, and diabetes.

Prostate Cancer Prostate Biopsy Complications Deter Patients From Re-Biopsy

Prostate Biopsy Complications Deter Patients From Re-Biopsy

Study participants with acute urinary retention after TRUS-guided prostate biopsy were 4.5 times more likely to skip a recommended re-biopsy than men who had no initial biopsy-related complications.

Urology Peri-Op RBC Transfusions Linked to Postoperative VTE

Peri-Op RBC Transfusions Linked to Postoperative VTE

Perioperative red blood cell transfusion linked to increased adjusted odds of VTE, DVT, PE.

Benign Prostatic Hyperplasia (BPH) Study: Non-Bothering Nocturia Worth Treating

Study: Non-Bothering Nocturia Worth Treating

Over 12 weeks of treatment, the mean number of nocturia episodes decreased by 1.1 and 0.9 in men who were and were not bothered by their symptoms, a non-significant difference between groups.

Prostate Cancer Long-Term Data Support Finasteride for PCa Prevention

Long-Term Data Support Finasteride for PCa Prevention

Clinicians can rest easier about recommending finasteride to more men, according to experts.

Erectile Dysfunction (ED) Erectile Dysfunction Strongly Predicts Cardiovascular Events

Erectile Dysfunction Strongly Predicts Cardiovascular Events

Men with erectile dysfunction (ED) are almost twice as likely to experience a cardiovascular event as those without ED.

Prostate Cancer Prostate Cancer Treatment Side Effects Linked to Distress

Prostate Cancer Treatment Side Effects Linked to Distress

Those with worse emotional distress also report worse urinary, sexual, bowel functions.

Prostate Cancer Biparametric MRI Improves Detection of Significant PCa

Biparametric MRI Improves Detection of Significant PCa

If externally validated, bpMRI could be used to triage men for prostate biopsy.

Urology FDA OKs 1st Biosimilar to Prevent Chemo-Related Infections

FDA OKs 1st Biosimilar to Prevent Chemo-Related Infections

Fulphila, biosimilar to Neulasta, helps reduce risk of infection during cancer treatment.

Prostate Cancer Abiraterone for mCRPC May Benefit Blacks More Than Whites

Abiraterone for mCRPC May Benefit Blacks More Than Whites

Abiraterone plus prednisone was associated with significantly greater PSA progression-free survival among patients who are black compared with white patients.

Prostate Cancer Enzalutamide for Advanced Prostate Cancer Does Not Worsen HRQoL

Enzalutamide for Advanced Prostate Cancer Does Not Worsen HRQoL

Enzalutamide decreases the risk of clinically meaningful deterioration in HRQoL compared with placebo in men with non-metastatic CRPC, new study finds.

Urology ASHP: SVP, Injectable Opioid Shortages Threaten Patient Care

ASHP: SVP, Injectable Opioid Shortages Threaten Patient Care

98.4% of respondents report moderate, severe shortages of morphine, hydromorphone, fentanyl.

Kidney Cancer Sunitinib Alone or After Surgery for mRCC Offers Similar Outcomes

Sunitinib Alone or After Surgery for mRCC Offers Similar Outcomes

New findings from the CARMENA trial contradict previous research showing better survival from cytoreductive nephrectomy followed by targeted therapy.

Urinary Incontinence Yoga Can Reduce Urinary Incontinence in Older Women

Yoga Can Reduce Urinary Incontinence in Older Women

Greater decrease in total UI frequency with yoga intervention versus time-and-attention control group.

Urology Reduced-Dose Anticoagulants Feasible for Extended VTE Tx

Reduced-Dose Anticoagulants Feasible for Extended VTE Tx

May be as effective as full-dose direct oral anticoagulants for extended-duration treatment.

Prostate Cancer AUA Updates Castration-Resistant Prostate Cancer Clinical Guideline

AUA Updates Castration-Resistant Prostate Cancer Clinical Guideline

"We are confident this guideline is fully aligned with the latest science on treatments for patients with non-metastatic and metastatic CRPC," said Michael Cookson, MD, member of the 2018 amendment panel.

Urology Senior Cancer Patients Also Benefit From Palliative Radiotherapy

Senior Cancer Patients Also Benefit From Palliative Radiotherapy

Benefit of palliative radiation for bone metastasis across age groups; older age should not preclude tx.

Prostate Cancer PSA Level 3 Months After Radiation Tx May Predict Outcome

PSA Level 3 Months After Radiation Tx May Predict Outcome

Findings for men with intermediate- and high-risk prostate cancer.

Urology Rivaroxaban Linked to Low VTE Recurrence in Active Cancer

Rivaroxaban Linked to Low VTE Recurrence in Active Cancer

Lower rate of VTE recurrence, but higher clinically relevant non-major bleeding versus dalteparin.

Prostate Cancer Current Smokers at Risk for Worse Prostate Cancer Outcomes

Current Smokers at Risk for Worse Prostate Cancer Outcomes

In a meta-analysis, smokers had an 89% greater risk of dying from prostate cancer compared with nonsmokers.

Prostate Cancer FDA Approves Yonsa for Metastatic Castration-Resistant Prostate Cancer

FDA Approves Yonsa for Metastatic Castration-Resistant Prostate Cancer

The approval of Yonsa was based on 2 randomized, placebo-controlled, multicenter Phase 3 studies in patients with mCRPC.

Urology Cryoablation Efficacious for Cancer Pain, Review Finds

Cryoablation Efficacious for Cancer Pain, Review Finds

Cryoablation also cuts the need for opioids at 24 hours post-treatment and at 3 months.

Prostate Cancer From 2008 to 2014, Prostate Cancer Testing, Treatment Down

From 2008 to 2014, Prostate Cancer Testing, Treatment Down

Sharpest decrease seen in privately insured men after 2011.

Benign Prostatic Hyperplasia (BPH) Nocturia More Bothersome Than Daytime LUTS

Nocturia More Bothersome Than Daytime LUTS

Clinicians tend to focus on the number of voids, but patients worry more about interrupted sleep.

Urology Immune Checkpoint Inhibitor Efficacy Varies by Sex

Immune Checkpoint Inhibitor Efficacy Varies by Sex

Magnitude of benefit of immune checkpoint inhibitors sex-dependent for patients with advanced cancers.

Kidney Stones Stone Composition Linked to Race, Ethnicity

Stone Composition Linked to Race, Ethnicity

Compared with whites, blacks, and Hispanics, Middle Easterners are more likely to have predominantly calcium oxalate monohydrate stones, but less likely to have hydroxyapatite stones.

Bladder Cancer PPD Skin Test Enhances BCG Therapy in Bladder Cancer

PPD Skin Test Enhances BCG Therapy in Bladder Cancer

Enhanced therapeutic effect of bacillus Calmette-Gurin tx in non-muscle invasive bladder cancer.

Reproductive Medicine Screening Blood Donations for Zika Virus Is Costly, Low Yield

Screening Blood Donations for Zika Virus Is Costly, Low Yield

Nine donations were confirmed positive; 6 of these had travelled to ZIKV-active areas.

Overactive Bladder (OAB) Hypoxia Not Linked With Nocturia

Hypoxia Not Linked With Nocturia

Rather intermittent oxygen desaturation was associated with a 3% greater likelihood of nocturia.

Kidney Stones Kidney Stones Linked to Oral Antibiotics

Kidney Stones Linked to Oral Antibiotics

Both younger age and more recent exposure to some antibiotics were associated with greater risks for kidney stones.

Prostate Cancer Overall, Drinking Wine Does Not Impact Prostate Cancer Risk

Overall, Drinking Wine Does Not Impact Prostate Cancer Risk

Findings show small increased risk with white wine, decreased risk with red wine

Prostate Cancer Predictors of Adverse Pathology After Prostate Cancer Surgery ID'd

Predictors of Adverse Pathology After Prostate Cancer Surgery ID'd

High PSA levels and larger number of positive biopsy cores are associated with positive surgical margins and extracapsular extension/seminal vesicle invasion after radical prostatectomy.

Urology Many Oncologists Discuss, Recommend Medical Marijuana

Many Oncologists Discuss, Recommend Medical Marijuana

But majority of oncologists don't feel knowledgeable enough to make these recommendations

Kidney Cancer Diabetes Ups Kidney Cancer Risk in Women

Diabetes Ups Kidney Cancer Risk in Women

Women with type 2 diabetes have a 1.5-fold higher risk of renal cell carcinoma compared with non-diabetic women.

Bladder Cancer Smoking Ups Bladder Cancer Risk, Lowers Prostate Cancer Risk

Smoking Ups Bladder Cancer Risk, Lowers Prostate Cancer Risk

Men and women who smoke are at 2.3-fold and 2.7-fold increased risk of bladder cancer compared with non-smokers.

Overactive Bladder (OAB) FDA Approves Mirabegron Solifenacin Combo for OAB

FDA Approves Mirabegron Solifenacin Combo for OAB

In clinical trials, the combination of Myrbetriq + solifenacin succinate was associated with greater improvements in the number of incontinence episodes per 24 hours (primary endpoint), the number of micturations per 24 hours (primary endpoint), and the volume voided per micturation (secondary endpoint) compared to placebo or to individual active components.

Bladder Cancer Post-op Intravesical Gemcitabine May Lower Bladder CA Recurrence Risk

Post-op Intravesical Gemcitabine May Lower Bladder CA Recurrence Risk

Instilling gemcitabine into the bladder immediately following resection of low-grade non-muscle-invasive bladder cancer significantly lowers recurrence risk.

Prostate Cancer USPSTF Updates Prostate Cancer Screening Recommendations

USPSTF Updates Prostate Cancer Screening Recommendations

The new statement emphasizes shared decision-making on screening for men aged 55 to 69 years who are at average risk for prostate cancer.

Kidney Cancer Parenting Fears Harm Well-Being of Women With Metastatic Cancer

Parenting Fears Harm Well-Being of Women With Metastatic Cancer

Findings based on survey of women with advanced cancer and dependent children.

Prostate Cancer Surgical Overtreatment of Prostate Cancer May Be Decreasing

Surgical Overtreatment of Prostate Cancer May Be Decreasing

Canadian study shows that nearly all men undergoing radical prostatectomy in Eastern Ontario in recent years have clinically significant prostate cancer.

Prostate Cancer Gleason 4+3 vs 3+4 PCa Tied To Higher Risk of Metastasis at Diagnosis

Gleason 4+3 vs 3+4 PCa Tied To Higher Risk of Metastasis at Diagnosis

Men with Gleason score (GS) 4+3 prostate cancer have a 3-fold higher risk of distant metastasis at diagnosis than those with GS 3+4 PCa.

Urology Art Intervention May Be Beneficial for Cancer Patients

Art Intervention May Be Beneficial for Cancer Patients

Brief bedside session associated with improved positive mood, pain scores and decreased anxiety

Prostate Cancer Obesity Linked to Lower Death Risk in Non-metastatic CRPC

Obesity Linked to Lower Death Risk in Non-metastatic CRPC

Obese men with non-metastatic castration-resistant prostate cancer have a 21% decreased risk of death compared with normal weight men, according to a study.

Urology Spermatogenesis Still Occurs in Men With Testicular Cancer

Spermatogenesis Still Occurs in Men With Testicular Cancer

Spermatogenesis often occurs away from tumor; findings may aid fertility planning, sperm retrieval.

Benign Prostatic Hyperplasia (BPH) Certain Anticholinergic Drugs Appear to Raise Dementia Risk

Certain Anticholinergic Drugs Appear to Raise Dementia Risk

Dementia link seen with antidepressant, urological, and anti-Parkinson's drugs.

Urinary Tract Infections (UTI) Lower UTIs More Likely to Resolve With Nitrofurantoin Than Fosfomycin

Lower UTIs More Likely to Resolve With Nitrofurantoin Than Fosfomycin

In a study of women with uncomplicated lower urinary tract infections, 70% of patients treated with nitrofurantoin had complete symptom resolution at 28 days vs 58% of those treated with fosfomycin.

Prostate Cancer Cancer Screening More Likely After a Previous False Positive

Cancer Screening More Likely After a Previous False Positive

Findings for both men and women with a false-positive prostate or breast cancer test result.

Overactive Bladder (OAB) Predictors of Pediatric OAB Healing Time Identified

Predictors of Pediatric OAB Healing Time Identified

Thicker bladder wall and a tower-shaped curve on uroflowmetry are associated with shorter healing periods among pediatric patients with overactive bladder.

Kidney Cancer Odds of Prescribing Drugs Up With Doc Receipt of Payments

Odds of Prescribing Drugs Up With Doc Receipt of Payments

Doctors who receive general payment for cancer drug more likely to prescribe drug marketed by company.

Reproductive Medicine ZIKV RNA Often ID'd in Semen of Men With Symptomatic Infection

ZIKV RNA Often ID'd in Semen of Men With Symptomatic Infection

Drop in ZIKV RNA shedding in semen seen within 3 months after illness onset but can persist longer.

Urology Polypharmacy More Likely for Cancer Survivors

Polypharmacy More Likely for Cancer Survivors

More cancer survivors prescribed 5 or more unique medications, including those with abuse potential

Urinary Incontinence Lasting Outcome Similar for ULS, SSLF for Pelvic Organ Prolapse

Lasting Outcome Similar for ULS, SSLF for Pelvic Organ Prolapse

No significant differences between peri-op behavioral muscle training and usual care at 5 years

Prostate Cancer BRCA Mutations Up Risk for PCa, Other Cancers

BRCA Mutations Up Risk for PCa, Other Cancers

Increased incidence of malignant disease, specifically prostate, melanoma, pancreas, breast cancers

Urinary Tract Infections (UTI) UTI Calculator Predicts Risk of Infant Urinary Tract Infection

UTI Calculator Predicts Risk of Infant Urinary Tract Infection

Calculator reduces testing and decreases the number of urinary tract infections that were missed

Prostate Cancer Survey Highlights Emotional Responses to Prostate Cancer

Survey Highlights Emotional Responses to Prostate Cancer

Sexual dysfunction was a chief complaint among survey respondents with prostate cancer.

Overactive Bladder (OAB) Nasal Spray for Nocturia Is Safe, Effective

Nasal Spray for Nocturia Is Safe, Effective

More patients taking desmopressin decreased their nightly voiding episodes by half or more.

Bladder Cancer Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer

One-year overall survival of 61% for gemcitabine and cisplatin plus ipilimumab.

Overactive Bladder (OAB) Urodynamics Influence OAB Treatment Decisions

Urodynamics Influence OAB Treatment Decisions

Clinicians' choice of treatment highly correlated with a diagnosis based on urodynamic studies.

Hypogonadism AUA Issues New Guidelines on Testosterone Deficiency

AUA Issues New Guidelines on Testosterone Deficiency

The new guidelines focus on accurate assessment and proper monitoring.

Overactive Bladder (OAB) Nonpharmacologic Therapy Ups Sleep Quality in Women With Nocturia

Nonpharmacologic Therapy Ups Sleep Quality in Women With Nocturia

At least half of women using tibial nerve stimulation or pelvic floor muscle training experienced fewer night awakenings, according to a new study.

Kidney Cancer Relative Visceral Fat Indicates Mortality Risk for Women With RCC

Relative Visceral Fat Indicates Mortality Risk for Women With RCC

An evaluation of patients with clear cell renal cell carcinoma revealed greater risk of death for female patients with high relative visceral fat area (rVFA), highlighting the significance of metabolic differences between men and women.

Urology Most Patients Are Unaware of Cancer Drug Shortages

Most Patients Are Unaware of Cancer Drug Shortages

Majority say they want to know about even minor consequences of cancer drug substitutions

Kidney Cancer Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors

Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors

Myocarditis with ICIs may be more common than initially thought; responds to higher steroid dosages

Prostate Cancer Diet, Exercise With Behavioral Counseling Can Reduce ADT Side Effects

Diet, Exercise With Behavioral Counseling Can Reduce ADT Side Effects

A novel component of an interventional program was cognitive-behavioral counseling administered in a group setting to promote behavioral change.

Prostate Cancer Metabolic Abnormalities Seen in Testicular Cancer Survivors

Metabolic Abnormalities Seen in Testicular Cancer Survivors

HTN, increased LDL and total cholesterol levels; lower rates of decreased HDL levels, abdominal fat

Prostate Cancer Socioeconomics May Not Explain Racial Gap in Prostate Cancer Mortality

Socioeconomics May Not Explain Racial Gap in Prostate Cancer Mortality

In a study, race independently predicted prostate cancer-specific mortality beyond a number of risk factors, including health insurance status.

Hypogonadism Dining Out Linked to Phthalates Exposure in US Population

Dining Out Linked to Phthalates Exposure in US Population

Teen high consumers of food outside the home had 55% higher androgen-disruptor levels.

Kidney Cancer Older Age May Up Risk for RCC-Related Death After Surgery

Older Age May Up Risk for RCC-Related Death After Surgery

The risk of dying from pT1a renal cell carcinoma after partial or radical nephrectomy increases along with patient age.

Prostate Cancer Low-Dose Abiraterone Noninferior for Castration-Resistant PCa

Low-Dose Abiraterone Noninferior for Castration-Resistant PCa

Low-dose AA with low-fat breakfast had greater effect on PSA; similar effect to standard dose

Bladder Cancer Non-Invasive Test for Urothelial Cancer Detection

Non-Invasive Test for Urothelial Cancer Detection

When combined with cytology, UroSEEK detected 95% of patients who developed bladder cancer

Benign Prostatic Hyperplasia (BPH) Expanded Indications Approved for UroLift

Expanded Indications Approved for UroLift

Benign Prostatic Hyperplasia (BPH) Inactivity, Sitting Tied to LUTS in Men

Inactivity, Sitting Tied to LUTS in Men

Low physical activity may increase risk of lower urinary tract symptoms in study of Korean men

Benign Prostatic Hyperplasia (BPH) Factors Affecting PAE Outcomes Identified

Factors Affecting PAE Outcomes Identified

Urology Pregnant Surgical Residents Face Several Challenges

Pregnant Surgical Residents Face Several Challenges

Most women receive 6 weeks or less of maternity leave; most feel leave duration is inadequate.

Prostate Cancer Perioperative Aspirin Use Need Not Prevent RP

Perioperative Aspirin Use Need Not Prevent RP

Perioperative aspirin use should not be considered an absolute contraindication to radical prostatectomy (RP).

Urology Heavier Patient Load Linked to Worse Urologist Ratings

Heavier Patient Load Linked to Worse Urologist Ratings

Poorer ratings seen with increase in Medicare patient load, with rating lowered by 0.04 per 100 patients.

Kidney Cancer Nivolumab Plus Ipilimumab Better for Advanced RCC

Nivolumab Plus Ipilimumab Better for Advanced RCC

Among intermediate- and poor-risk patients, the risk for death was 37% lower with nivolumab plus ipilimumab than with sunitinib.

Urology Periodontitis May Increase Cancer Risk

Periodontitis May Increase Cancer Risk

Strongest associations found for lung and colorectal cancer

Prostate Cancer Finasteride Cuts Prostate Cancer Risk Long Term

Finasteride Cuts Prostate Cancer Risk Long Term

New study shows that men are at lower risk of prostate cancer for years after they stop taking the medication.

Benign Prostatic Hyperplasia (BPH) 5α-Reductase Inhibitors Not Tied to High-Grade Prostate Cancer

5α-Reductase Inhibitors Not Tied to High-Grade Prostate Cancer

A previous study showed that using 5-ARIs to treat benign prostate hyperplasia decreased the risk of low-grade PCa.

Urology Circulating Tumor DNA Assays of Limited Use for Cancer Screening

Circulating Tumor DNA Assays of Limited Use for Cancer Screening

No evidence for circulating tumor DNA assays in early-stage cancer, residual disease detection

Hypogonadism Testosterone Therapy Guidelines Updated

Testosterone Therapy Guidelines Updated

Screening and treating all healthy men older than 65 years with testosterone is discouraged.

Reproductive Medicine Low Sperm Count Linked With Cardiometabolic Conditions, Hypogonadism

Low Sperm Count Linked With Cardiometabolic Conditions, Hypogonadism

Low sperm counts linked to hypogonadism, higher BMI, hypertension, dyslipidemia, metabolic syndrome

Erectile Dysfunction (ED) FDA Warns Against Unapproved Erectile Dysfunction Products

FDA Warns Against Unapproved Erectile Dysfunction Products

Unapproved erectile dysfunction drugs are touted as a "healthy man alternative to the little blue pill."

Reproductive Medicine Daily Pill Promising for Male Birth Control

Daily Pill Promising for Male Birth Control

Dimethandrolone undecanoate lowers testosterone; well tolerated, mild effects of weight gain, lower HDL

Prostate Cancer Dose-Escalated RT Does Not Improve Survival in Intermediate-Risk PCa

Dose-Escalated RT Does Not Improve Survival in Intermediate-Risk PCa

Researchers observed reductions in biochemical failure and distant metastasis rates in patients who had dose-escalated radiation therapy.

Urology Virtual Reality Can Aid Pain Relief From Medical Procedures

Virtual Reality Can Aid Pain Relief From Medical Procedures

VR effective for reducing pain and distress of even extremely painful procedures

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