Generic Name and Formulations:
Levothyroxine sodium 25mcg, 50mcg (dye-free), 75mcg, 88mcg, 100mcg, 112mcg, 125mcg, 150mcg, 175mcg, 200mcg, 300mcg; scored tabs.
Gemini Laboratories, LLC
Indications for UNITHROID:
Take in AM on empty stomach. Hypothyroidism: 1.7mcg/kg once daily. >50yrs, or <50yrs with cardiovascular disease: initially 25–50mcg once daily; titrate in increments of 12.5–25mcg every 4–6 weeks. Elderly with cardiovascular disease: initially 12.5–25mcg once daily; titrate in increments of 12.5–25mcg every 4–6 weeks. Usual max 200mcg/day. Severe hypothyroidism: initially 12.5–25mcg once daily; titrate in increments of 25mcg/day every 4 weeks. Subclinical hypothyroidism, secondary or tertiary hypothyroidism: see literature.
Give once daily on empty stomach. May crush tabs and mix in 5–10mL water. Hypothyroidism: 0–3months: 10–15mcg/kg per day; 3–6months: 8–10mcg/kg per day; 6–12months: 6–8mcg/kg per day; 1–5yrs: 5–6mcg/kg per day; 6–12yrs: 4–5mcg/kg per day; >12yrs: 2–3mcg/kg per day; growth and puberty complete: as adult. Chronic or severe hypothyroidism: initially 25mcg/day; titrate in increments of 25mcg every 4weeks. Infants with serum T4<5mcg/dL: initially 50mcg/day.
Uncorrected adrenal insufficiency. Untreated thyrotoxicosis. Acute MI.
Not for treatment of obesity for weight loss.
Ineffective for weight reduction in euthyroid patients. Not for treatment of infertility. Cardiovascular disease. Seizures. Adrenocortical insufficiency. Increased sensitivity in severe hypothyroidism. Autonomous thyroid tissue. Myxedema coma: use IV levothyroxine. Elderly. Pregnancy (Cat.A); do not discontinue due to pregnancy. Nursing mothers.
See full labeling. Absorption reduced by some foods (eg, soy, fiber), aluminum and magnesium hydroxide, simethicone, calcium carbonate, sodium polystyrene sulfonate, bile acid sequestrants, iron, sucralfate (give at least 4hrs apart). Potentiates, and is potentiated by, tri- and tetracyclic antidepressants, sympathomimetics. Antagonized by hepatic enzyme inducers (eg, carbamazepine, phenytoin, phenobarbital, rifampin), sertraline. Antagonizes digoxin. Marked hypertension and tachycardia with ketamine. Estrogens affect thyroid function tests. Monitor oral anticoagulants, antidiabetic agents, theophylline.
Hyperthyroidism, decreased bone mineral density, transient alopecia; seizures (rare); pseudotumor cerebri in children.
Renal and Urology News Articles
- Gadolinium-Based Contrast May Up Acute Kidney Injury Risk in CKD
- Delayed Prostate Cancer Treatment May Up Relapse Risk
- Review: Desmopressin Decreases Nocturia Episodes
- Surgery, Radiation Regimens for High-Grade PCa Offer Similar Outcomes
- Salvage Prostatectomy May Benefit Some Prostate Cancer Patients
- Changes in Renal Cell Carcinoma Pathologic Staging and Histologic Grading
- Nocturia, Overactive Bladder Improved With PTNS
- Many Americans Unaware of Promise of Personalized Medicine
- Noninferior CV Outcomes for Linagliptin in T2D With High CV, Renal Risk
- VDRAs Do Not Lower Cardiovascular Event Risk in HD
Sign Up for Free e-newsletters
NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)