HCV-infected kidney donors could save lives

1. No HCV infection was detected in patients receiving HCV-infected kidneys 12 weeks following treatment. 2. No antiviral treatment-related complications occurred recipients of HCV-infected kidneys. Evidence Rating Level: 2 (Good) Study Rundown: Kidney failure and end-stage kidney disease result in significant morbidity and mortality. While kidney transplant is a viable solution for patients with kidney []

Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trial

1. Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients. 2. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission. Evidence Rating Level: 1 (Excellent) Study []

Meropenem-vaborbactam non-inferior to piperacillin-tazobactam for complicated urinary tract infections: The TANGO I trial

1. In this randomized controlled trial, meropenem-vaborbactam was found to be non-inferior to piperacillin-tazobactam for treating complicated urinary tract infections (UTIs). 2. The rate of adverse events were similar between groups. Evidence Rating Level: 1 (Excellent) Study Rundown: As carbapenemases become more prevalent among organisms that cause complicated Urinary Tract Infections (UTIs), the need for []

No benefit of sodium bicarbonate or acetylcysteine for prevention of complications after angiography: The PRESERVE trial

1. Amongst patients undergoing angiography, neither sodium bicarbonate nor acetylcysteine were effective in preventing a composite outcome of death, need for dialysis, or persistent kidney injury. 2. The treatments were also ineffective in reducing risk of contrast-associated acute kidney injury. Evidence Rating Level: 1 (Excellent) Study Rundown: Contrast used in angiography is associated with numerous []

ICD placement in CKD patients increases hospitalizations without survival benefit

1. Adults with chronic kidney disease (CKD) and heart failure with reduced LVEF who received implantable cardioverter defibrillators (ICDs) did not differ from matched non-ICD patients with relation to all-cause mortality. 2. However, ICD placement in patients with CKD was associated with increased risk of heart failure-related and any-cause hospitalization. Evidence Rating Level: 2 (Good) []

Living kidney donation associated with some increased health risks

1. Living kidney donation was associated with higher diastolic blood pressure, lower estimated glomerular filtration rates, and increased relative risk of preeclampsia and end-stage renal disease (ESRD). 2. Data did not show that donors have a higher risk for type 2 diabetes, hypertension, cardiovascular disease, negative psychosocial health outcomes, reduced quality of life, or mortality. []

Regional variation in CT imaging is associated with nephrectomy risk

1. Regional variation in cumulative risk of an individual having a chest or abdominal CT in the United States was positively correlated with the risk of both total and partial nephrectomy, as well as any renal procedure (including renal ablation). 2. This association may reflect incidental detection and over-diagnosis of renal masses, with an increased []

Blood pressure control best achieved with a multilevel, multicomponent approach

1. Team-based, multilevel implementation strategies were the most effective at reducing systolic blood pressure (BP). 2. Team-based care with medication titration by non-physicians, health coaching, and home BP monitoring shown to be effective at improving diastolic BP among patients. Evidence Rating Level: 1 (Excellent) Study Rundown: Hypertension is the leading risk factor for cardiovascular disease []

Outcomes after left ventricular assist device implantation significantly worse for those with end-stage renal disease

1. Patients with end-stage renal disease (ESRD) have significantly worse survival outcomes following left ventricular assist device (LVAD) implantation compared to recipients without ESRD. 2. The median time to death was substantially shorter in those with ESRD, with many patients dying during the index hospitalization. Evidence Rating Level: 2 (Good) Study Rundown: With advancement of []

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