Coaching to improve water intake does not improve kidney function in adults with chronic kidney disease

1. In this randomized controlled trial, coaching to improve daily fluid intake did not improve kidney function in patients with Chronic Kidney Disease. 2. Increasing fluid intake via coaching was adequate to lower vasopressin secretion in patients. Evidence Rating Level: 1 (Excellent) Study Rundown: In both preclinical animal models and clinical human studies, increased water []

Hospice care may not decrease Medicare costs in patients on maintenance dialysis

1. In this cross-sectional study, of those patients on maintenance hemodialysis that were referred to hospice care, 41.5% received care for only 3 days or less. 2. While patients who were enrolled in hospice care were less likely to die in hospital or undergo intensive procedures prior to death, they were more likely to be []

Optimizing organ donations from overdose deaths may help address national organ shortage

1. U.S. transplants using organs from overdose-death donors (ODDs) has increased 24-fold from 2000 to 2016, and transplant outcomes from organs donated by ODDs have been noninferior to those donated by trauma-death donors (TDDs) and medical-death donors (MDDs). 2. Compared to TDD organs, ODD kidneys and livers were discarded at a greater rate. Evidence Rating []

Medicare pre-ESRD care results in more dialysis initiation but also increased two-year mortality

1. Veterans receiving pre-end stage renal disease (ESRD) nephrology care in under the Medicare system were more likely to undergo dialysis and had a higher two-year mortality rate than veterans that received pre-ESRD care through the Department of Veteran's Affairs (VA). 2. Differences in dialysis initiation between Medicare and VA were more pronounced in patients []

Barber-facilitated health promotion reduces blood pressure among black male barber patrons

1. Non-Hispanic black male barber patrons prescribed antihypertensive therapy with barber encouragement along with lifestyle modification experienced greater reductions in blood pressures compared to those who received lifestyle modification advice alone. 2. A greater percentage of participants in the intervention group achieved a 130/80 mm Hg blood pressure goal compared to participants in the control []

Nivolumab plus ipilimumab improves survival in advanced renal cell carcinoma

1. Amongst patients with advanced renal-cell carcinoma and an intermediate or poor prognosis, nivolumab plus ipilimumab was superior to sunitinib alone in improving overall survival. 2. Though not statistically compared, there was a lower incidence of grade three or four adverse events with nivolumab plus ipilimumab, although more patients in the combination therapy arm stopped []

HCV-infected kidney donors could save lives

1. No HCV infection was detected in patients receiving HCV-infected kidneys 12 weeks following treatment. 2. No antiviral treatment-related complications occurred recipients of HCV-infected kidneys. Evidence Rating Level: 2 (Good) Study Rundown: Kidney failure and end-stage kidney disease result in significant morbidity and mortality. While kidney transplant is a viable solution for patients with kidney []

Balanced crystalloids decreases adverse kidney events compared to saline among critically ill patients: The SMART trial

1. Use of balanced crystalloids (lactated Ringers or Plasma-Lyte A) was associated with a significant reduction in acute kidney injury events compared to normal saline among intensive care unit (ICU) patients. 2. Use of balanced crystalloids was also associated with lower though nonsignificant in-hospital mortality at 30-days after admission. Evidence Rating Level: 1 (Excellent) Study []

Meropenem-vaborbactam non-inferior to piperacillin-tazobactam for complicated urinary tract infections: The TANGO I trial

1. In this randomized controlled trial, meropenem-vaborbactam was found to be non-inferior to piperacillin-tazobactam for treating complicated urinary tract infections (UTIs). 2. The rate of adverse events were similar between groups. Evidence Rating Level: 1 (Excellent) Study Rundown: As carbapenemases become more prevalent among organisms that cause complicated Urinary Tract Infections (UTIs), the need for []

No benefit of sodium bicarbonate or acetylcysteine for prevention of complications after angiography: The PRESERVE trial

1. Amongst patients undergoing angiography, neither sodium bicarbonate nor acetylcysteine were effective in preventing a composite outcome of death, need for dialysis, or persistent kidney injury. 2. The treatments were also ineffective in reducing risk of contrast-associated acute kidney injury. Evidence Rating Level: 1 (Excellent) Study Rundown: Contrast used in angiography is associated with numerous []

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