Kidneys Transplanted in France Would Be Discarded in US
Donor profile index of transplanted kidneys has risen modestly in US, with greater increase in France.
(HealthDay News) -- Many kidneys transplanted in France would be discarded in the United States, according to a study presented at the American Society of Nephrology's Kidney Week, held Oct. 23 to 28 in San Diego.
Olivier Aubert, MD, PhD, from the Paris Translational Research Center for Organ Transplantation, and colleagues compared kidney quality and outcomes between the United States and France using data from 2004 to 2014.
The researchers found that during this period, 125,936 kidneys were procured for transplant in the United States and 4287 were procured for transplant in the Paris Transplant Group cohort. They found a greater proportion of higher-risk transplanted kidneys among French vs US kidneys, as measured by the kidney donor profile index (KDPI; median, 65 vs 42). The KDPI of US kidneys increased modestly during the study period (mean, 42 to 44), while a greater increase was seen in France (mean KDPI, 54 to 67), indicating more aggressive organ use. For higher-KDPI kidneys transplanted in France, 3- and 5-year death-censored graft survival, respectively, was 88 and 83% for KDPI 80 to 90 kidneys, 83 and 79% for KDPI 91 to 99 kidneys, and 81 and 78% for KDPI 100 kidneys. Many transplanted French kidneys would have had a high probability of discard in the United States.
"By comparing transplant practices in 2 countries, we provide fresh evidence that older deceased donor organs are a valuable underutilized resource," one of the co-authors said in a statement.
Aubert O, Reese PP, Bouatou YR, Viglietti D, Lefaucheur C, Loupy A. Exploring the Viability of Kidneys Discarded in the US: A Comparison of Kidney Utilization Patterns and Outcomes in the US and France. Kidney Week 2018. Abstract: SA-OR003