Blood Type A2 to B Kidney Transplant Feasible

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No difference in patient, graft survival; increased costs seen for A2 to B deceased donor kidney transplant
No difference in patient, graft survival; increased costs seen for A2 to B deceased donor kidney transplant

(HealthDay News) -- Outcomes are similar for blood type A2 to blood type B and B to B deceased donor kidney transplantation (DDKTx), according to a study published online in the Journal of the American College of Surgeons.

David Shaffer, MD, from the Vanderbilt University Medical Center in Nashville, Tennessee, and colleagues conducted a retrospective cohort analysis of 29 consecutive A2 to B and 50 B to B DDKTx. Patients were followed for 3 years after transplant.

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The researchers found that African-Americans comprised 72 and 60% of the A2 to B and B to B groups. No difference was seen in mean wait time (58.8 vs 70.8 months). In A2 to B DDKTx, anti-A immunoglobulin G titers were increased at discharge and 4 weeks. Patient or graft survival, serum creatinine, and estimated glomerular filtration rate (eGFR) did not differ significantly; during the follow-up period, the trajectories of serum creatinine and eGFR differed between the groups. Significantly higher mean transplant total hospital costs ($114,638 vs $91,697) and hospital costs net organ acquisition costs ($42,356 vs $20,983) were significantly higher for A2 to B transplants.

"This was the first study to report on the costs associated with A2 to B transplantation," Shaffer said in a statement. "One of our next steps is to look at costs over a broader period of time. We also plan to study ways of bringing down costs."

Reference

Shaffer D, Shaffer D, Feurer ID, Rega SA. A2 to B Kidney Transplantation in the Post-Kidney Allocation System Era: A 3-year Experience with Anti-A Titers, Outcomes, and Cost. J Am Coll Surg. DOI:10.1016/j.jamcollsurg.2018.12.023

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