Urologic Disorders

Renal Stones Linked to Migraine Drug

Topiramate (Topamax), a drug for epileptic seizures and migraine headaches, may cause systemic metabolic acidosis, lower urinary citrate excretion, and raise urinary pH if used long-term, data suggest. The side effects could significantly increase the likelihood of calcium phosphate stones, investigators warn.

Medical Management of Urolithiasis

IN THE United States, the incidence of urinary stone disease is about 12% in men and 7% in women, and evidence suggests that these numbers are increasing. For patients who form stones, the likelihood of a recurrence is nearly 50% within five years and up to 95% over a lifetime.

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