Urinary supersaturation of uric acid rises with BMI, which could explain why obese individuals have a higher incidence of kidney stones, a study indicates.
Topiramate (Topamax), a drug for epileptic seizures and migraine headaches, may cause systemic metabolic acidosis, lower urinary citrate excretion, and raise urinary pH if used long-term, data suggest. The side effects could significantly increase the likelihood of calcium phosphate stones, investigators warn.
IN THE United States, the incidence of urinary stone disease is about 12% in men and 7% in women, and evidence suggests that these numbers are increasing. For patients who form stones, the likelihood of a recurrence is nearly 50% within five years and up to 95% over a lifetime.