Complete Response to Atezolizumab in UC Appears Durable
The median duration of complete response to atezolizumab in patients with locally advanced or metastatic urothelial carcinoma is more than 2 years, new data suggest.
Diagnosis & Disease Information
Earlier Pembrolizumab Use May Be Beneficial in mUC
In a phase 2 study, patients with metastatic urothelial carcinoma who had stable disease on first-line platinum-based chemotherapy experienced a delay in disease progression when switched to pembolizumab.
Risk Factors for Poor Survival, Recurrence in UTUC Identified
Failing to use metformin for diabetes treatment was among the more surprising risk factors for bladder cancer recurrence following surgery for upper tract urothelial carcinoma.
No Surgery in Nearly 11% of Localized UTUC Cases
In a study, median survival time was significantly shorter among patients managed nonsurgically rather than surgically for localized upper tract urothelial carcinoma.
NAC Prior to UTUC Surgery Suggests Clinical Benefit
In a phase 2 trial, more than half of patients who received neoadjuvant chemotherapy for high-risk upper tract urothelial carcinoma had a pathologic response that was associated with improved survival.
Core-Needle Biopsies Safe, Effective in UTUC
In a small study of patients who underwent radical surgery for upper tract urothelial carcinoma, investigators found no evidence of tract seeding.
Mitomycin C Instillation May Lower UTUC Recurrence Risk
A single-dose instillation of mitomycin C immediately following therapeutic ureteroscopy upper tract urothelial carcinoma decreased the risk of urothelial recurrence.
Neoadjuvant Chemo May Lower Risk of UTUC Recurrence in the Bladder
Neoadjuvant chemotherapy prior to radical surgery for high-grade upper tract urothelial carcinoma lowered the risk of disease recurrence in the bladder by 66%, a study found.
Mitomycin Gel for UTUC Has Potential to Avert Nephrectomy
Instillation of an investigational mitomycin gel formulation obviated the need for nephrectomy in nearly half of individuals with low-grade upper tract urothelial carcinoma.
Adjuvant Chemo After Nephroureterectomy May Aid Survival in UTUC
Adjuvant chemo is associated with overall survival benefit in patients with locally advanced and/or positive regional lymph node disease.
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