Study: Template-Based LND May Aid Local UTUC Control
Template-based lymph node dissection in patients with upper tract urothelial carcinoma could facilitate better local disease control by eliminating micrometastasis, according to investigators.
Upper Tract Urothelial Carcinoma
Prioritizing Urologic Cancer Cases During the COVID-19 Pandemic
Investigators performed a literature review to better understand how delays in treatment might affect clinical outcomes in urologic cancer patients, including the risk of upstaging, recurrence, and mortality.
Pathologic Stage at RNU Predicts Oncologic Outcomes in High-Grade UTUC
A study found no survival differences between high-grade UTUC patients who at the time of radical nephroureterectomy achieved low-grade disease following neoadjuvant chemotherapy and those who had inherently low-stage disease and did not receive chemotherapy.
Evolving Strategies in the Management of Low-Grade UTUC
Upper tract urothelial cancer (UTUC) represents approximately 5%-10% of all urothelial cancers, although the incidence is increasing. Modifiable risk factors include exposure to toxins such as tobacco smoke, industrial toxins (including aromatic hydrocarbons, coal, coke, chlorinated solvents, and tars), arsenic, the analgesic phenacetin, and aristolochic acid. Produced by plants of the genus Aristolochia, aristolochic acid…
UGN-101 Active in Chemoablation of Upper Tract Urothelial Cancer
59% of patients had complete response at 4 to 6 weeks after initial therapy.
Neoadjuvant Chemo Possibly a Better Option in High-Grade UTUC Cases
Patients with high-grade upper tract urothelial carcinoma who respond to neoadjuvant chemotherapy have a reduced risk of death following surgery compared with those who receive adjuvant chemotherapy, a study found.
Jelmyto Approved for Low-Grade Upper Tract Urothelial Cancer
The Food and Drug Administration (FDA) has granted expedited approval of Jelmyto (mitomycin for pyelocalyceal solution; UroGen Pharma) for the treatment of adult patients with low-grade upper tract urothelial cancer (LG-UTUC). The approval was based on data from the ongoing open-label, single-arm, phase 3 OLYMPUS study that assessed the efficacy of Jelmyto in 71 adults…
Multifocal Tumors in UTUC Are a Risk Factor for Recurrence
In a study, patients who had upper tract urothelial carcinoma with multifocal tumors had a 40% higher risk for urinary bladder recurrence than those with single tumors.
Perioperative Chemotherapy Improves UTUC Outcomes, Meta-Analysis Confirms
Neoadjuvant and adjuvant chemotherapy for patients undergoing nephroureterectomy for upper tract urothelial carcinoma are associated with decreased risks of metastasis and cancer-specific mortality, a meta-analysis showed.
Mitomycin C May Reduce Urothelial Recurrence Risk in UTUC
In a small study, single-dose instillation of mitomycin C immediately following therapeutic ureteroscopy for upper tract urothelial carcinoma was associated with an 87% decreased risk of urothelial recurrence.
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