A meta-analysis comparing segmental ureterectomy and radical nephroureterectomy for UTUC suggests that selected patients, such as those with low-risk ureteral tumors, might benefit from segmental ureterectomy.
Chemotherapy should be considered part of multi-modal treatment for nonmetastatic UTUC patients when clinically feasible, according to researchers.
For some UTUC patients, adjuvant chemotherapy may improve survival over radical nephroureterectomy alone,
In a small study of patients without a history of bladder cancer who undergo radical nephroureterectomy for upper tract urothelial carcinoma, preoperative pyuria was associated with a 1.7-fold increased risk of intravesical recurrence, a study found.
In a phase 2 trial, a regimen of gemcitabine plus eribulin compared favorably with other regimens for the first-line treatment of cisplatin-ineligible patients with metastatic urothelial carcinoma.
Patients who undergo surgical resection of nonmetastatic upper tract urothelial carcinoma with isolated lymph node involvement have a 5-year overall survival rate of only 24%, a study found.
Female sex, prior urinary tract infection, and longer operative time are associated with increased odds of UTI following flexible ureteroscopy, a study found.
In a single-center study of patients with asymptomatic microscopic hematuria, renal ultrasonography demonstrated 100% sensitivity for detecting upper tract urothelial carcinoma and renal cell carcinoma.
In a study of patients with upper tract urothelial carcinoma, Asians were 27% more likely than whites to die from the disease.
An FDA pooled analysis suggests that certain AEs were associated with response and overall survival in PD-1/PD-L1-treated urothelial cancer.
