Segmental Ureterectomy May Be an Option for High-Risk Ureteral Tumors
In patients with high-risk tumors, those treated with segmental ureterectomy did not have worse overall survival compared with those who underwent radical nephroureterectomy.
Upper Tract Urothelial Carcinoma
Neoadjuvant and Adjuvant Chemo More Effective Than RNU Alone in UTUC
As current guidelines only include a weak recommendation to offer perioperative chemotherapy to patients with muscle-invasive upper tract urothelial carcinoma, a new meta-analysis including evidence up to February 2020 provides potentially useful information.
Neoadjuvant Chemo May Improve Overall Survival in UTUC
Survival was significantly improved in patients with greater disease burden.
EAU Issues Updated UTUC Guidelines
The 2020 update highlights the importance of accurate diagnosis of upper tract urothelial carcinoma, risk stratification, close follow-up of patients receiving kidney-sparing management, and other key aspects of care.
Data Support Ureteroscopy for Upper Tract Urothelial Carcinoma
Patients who underwent ureteroscopic management of low-risk UTUC had a 5-year cancer-specific survival rate of 92.6%.
Survival Remains Poor in High-Risk Muscle-Invasive Urothelial Carcinoma
Overall and disease-free survival among patients undergoing surgical resection for MIUC is low despite increasing use of neoadjuvant chemotherapy.
Glasgow Prognostic Score Predicts Adverse Pathology, Survival in UTUC
In a study, modified Glasgow prognostic score predicted nonorgan-confined disease and lymph node invasion at surgery.
Data Support URS Biopsies for Diagnosing UTUC
The grade-to-grade match between URS biopsy and final pathology was 66% for low-grade and 97% for high-grade tumors , according to a recent systematic review and meta-analysis.
Metastatic UTUC Has Poor Prognosis, Low Chemosensitivity
In a large case series, stage IV disease at diagnosis and 3 or more metastatic sites were both associated with worse prognosis.
UTUC Incidence Rising in The Netherlands
A study of 13,438 patients with upper tract urothelial carcinoma in The Netherlands found that the incidence of the cancer increased significantly from 1993 to 2017, with no improvement in survival except for those with metastatic disease.
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