Fracture Risk Up With Insulin Compared With Metformin in T2DM
Risk for major osteoporotic fractures up for insulin versus metformin for those with HbA1c <7 percent, BMI <25 kg/m2
Medications
SGLT2 Inhibitors Safe for KTRs, Data Show
The safety profile of SGLT2 inhibitors in kidney transplant recipients with type 2 diabetes is similar to that of other patient populations, new research suggests.
Early Use of RAAS Inhibitors May Benefit Children With Lupus Nephritis
Real-world data on use of RAAS inhibitors can be used to support future pragmatic studies to optimize management of childhood-onset SLE, according to investigators.
ADA: Tirzepatide Improves Kidney Outcomes in T2DM With Increased CV Risk
Fewer renal complications seen with tirzepatide versus insulin glargine in adults with T2D and increased cardiovascular risk
New Cancer Drugs Approved Faster in US Than Europe
FDA received licensing applications sooner and had shorter review times, compared to the European Medicines Agency
Uric Acid-Lowering Therapy May Increase Risk for CKD
Study findings do not support initiation of uric acid-lowering therapy to prevent CKD.
RAAS Inhibitors Reduce Proteinuria in Primary FSGS
A meta-analysis revealed that RAAS inhibitor monotherapy in patients with primary FSGS is significantly associated with a 32% reduction in proteinuria.
Heart Failure Hospitalization Risk Compared With Empagliflozin vs Other Glucose-Lowering Tx
The EMPRISE study assessed the efficacy and safety of empagliflozin use in approximately 500,000 adults with type 2 diabetes.
More Clinical Benefits of Molnupiravir ID’d in COVID-19
Compared with placebo, normalization of C-reactive protein and oxygen saturation faster, with improvements seen on day 3 of treatment
Sodium Thiosulfate May Slow Vascular Calcification in Hemodialysis
No medication is currently approved to treat vascular calcification in this population.
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