ACR: Low-Dose Hydroxychloroquine Tied to More Hospitalizations for Lupus Flares
Both weight-based and non-weight-based low-dose HCQ associated with increased hospitalizations for SLE
Medications
FDA: Prolia Use in Dialysis Patients May Cause Severe Hypocalcemia
According to a long-term safety study and a separate FDA internal study, Prolia had an increased risk of hypocalcemia in patients with advanced kidney disease on dialysis.
Immunosuppression Ups Infection Risks in Glomerular Disease
Both corticosteroids and nonsteroid immunosuppressive medications were associated with an increased infection risk, investigators found.
Belimumab Efficacy for Lupus Nephritis Maintained Beyond 2 Years
Belimumab treatment continued to protect the kidneys in adults with active lupus nephritis.
High-Dose Dexamethasone May Be Harmful for Patients With COVID-19
Patients hospitalized with COVID-19 receiving supplemental oxygen had similar mortality outcomes with high- vs standard-dose dexamethasone, but evidence suggests higher dexamethasone doses may be associated with adverse outcomes. These study results were presented at IDWeek 2022, held from October 19 to 23, in Washington, DC. Anti-inflammatory agents, such as dexamethasone, are standard treatment for COVID-19…
Lupus Nephritis Drug Voclosporin Shows Efficacy, Safety Over 3 Years
One study focused on patients with severe lupus nephritis, who are at greatest risk for kidney failure.
Continuing ACE Inhibitors Despite Potassium Change Can Have Benefits
Stopping renin-angiotensin-aldosterone inhibitors after hyperkalemia may offset their potential clinical benefits, according to investigators.
Patiromer Use for Acute Hyperkalemia Characterized
Investigators report a low incidence of hypokalemia and hypomagnesemia after a single dose of patiromer monotherapy.
FDA Panel Votes on Tenapanor for Hyperphosphatemia in CKD
For patients who tolerated and remained on therapy, the average treatment effect on serum phosphorus was about -0.7mg/dL.
Potassium Binder Use Long Term Linked With Better Outcomes
Potassium binders historically have been used short term or intermittently.
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