Belimumab May Reduce Organ Damage in SLE, Lupus Nephritis
Belimumab is a monoclonal antibody that inhibits B-lymphocyte stimulator.
Lupus Nephritis
Infection Risk Varies by Lupus Nephritis Induction Therapy
Adverse effects of induction therapies for lupus nephritis may limit their use.
Clinical Biomarkers of Lupus Nephritis Activity Unreliable
Proteinuria and estimated glomerular filtration rate cannot accurately distinguish between ongoing inflammatory injury and chronic kidney damage in lupus nephritis, investigators pointed out.
Tacrolimus May Be an Alternative for First-Line Lupus Nephritis Therapy
In a study, the calcineurin inhibitor tacrolimus proved to be noninferior to intravenous cyclophosphamide.
International Consensus Developed for Corticosteroid Dosing in Childhood-Onset SLE With Proliferative Lupus Nephritis
Researchers developed a consensus-based standardized corticosteroid dosing regimen for patients with childhood-onset systemic lupus erythematosus with lupus nephritis.
Scientists Report ‘Rogue Antibodies’ Behind Severe Clotting With COVID-19
Study authors suggest future research assess the potential benefits of screening COVID-19 patients for antiphospholipids and other autoantibodies
Cost-Effectiveness of Belimumab, Voclosporin for Lupus Nephritis Explored
Although studies support the clinical benefits of belimumab and voclosporin, their cost-effectiveness has not been established.
Lupus Nephritis Guideline Disparities Identified by Working Group
The board of the Immunonephrology Working Group of the European Renal Association reviewed 2 recent guidelines to establish if and how some of the differences may affect clinical practice.
Refractory Lupus Nephritis Responds to Add-On Tacrolimus
Nephrotoxicity remains a major concern with the use of calcineurin inhibitors.
Intravenous Methylprednisolone Enhances CD46-Mediated Tr1 Cells in Lupus Nephritis Remission
Researchers assessed molecular changes of Tr1 cells through CD46 cytoplasmic tail in patients with lupus nephritis who received intravenous methylprednisone therapy.
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