In an observational study, furosemide doses of 250 to 500 mg and spironolactone doses of 50 to 100 mg were independently associated with approximately 14% and 20% increased odds of hyponatremia, respectively.
Adding furosemide with or without sodium chloride to fluid restriction is not more effective than fluid restriction alone at correcting hyponatremia in patients with the syndrome of inappropriate antidiuresis, a study found.
In a study, users of the older formulation of desmopressin had a 13-fold higher rate of hyponatremia than users of oxybutynin.
Among CKD patients older than 60 years, chronic prolonged hyponatremia is associated with 36% increased odds of hip fracture in adjusted analyses, a study found.
Development of kidney stones is 6.2-fold more likely among patients with persistent hyponatremia than those without a history of hyponatremia.
A novel oral formulation of urea increased plasma sodium levels significantly and was well tolerated, according to investigators.
AUSTIN, Texas—Hyponatremia isstrongly associated with an increasedrisk of fracture and osteoporosis,according to the findings of a newsystematic review and meta-analysispresented at the National KidneyFoundation’s 2018 Spring ClinicalMeetings. The meta-analysis, which included25 studies, found that hyponatremia,defined as a serum sodium level below135 mmol/L, was associated with 2.7-and 2.5-fold greater odds of fracture inprospective and retrospective studies,respectively,…
Treatment with a novel urea formulation that is available in the United States safely improves plasma sodium levels, small study shows.
Sodium levels below 140 mEq/L associated with a higher death risk vs levels of 140 to less than 142 mEq/L.
Hypontrameia is linked to increased risk of hip fracture in elderly individuals.
