Hyperkalemia Drug Safe for Use in Adolescent CKD Patients
Preliminary data show that treatment with patiromer is well tolerated and results in clinically meaningful decreases in serum potassium.
Hyperkalemia
Hyperkalemia Excursions May Better Predict Death Risk in Hemodialysis
In a study of hemodialysis patients, the more hyperkalemia excursions, the higher the risk for short-term mortality.
Hyperkalemia Impairs Quality of Life in CKD, Dialysis
KDQOL and EuroQol-5D-3L responses show worse quality of life among kidney disease patients who develop hyperkalemia.
Hyperkalemia Progression Rates Described
In a study, nearly 17% of patients with mild hyperkalemia progressed to moderate to severe hyperkalemia during the 2 years following the date of their first mild hyperkalemia event.
Stopping ACE Inhibitors, ARBs After Hyperkalemia Episode Ups Death Risk in CKD
Patients with CKD who discontinued ACE inhibitors or angiotensin receptor blockers after a hyperkalemia episode had a 2.6-fold increased risk of all-cause mortality compared with patients who continued taking the drugs.
Hyperkalemia Ups CKD Progression Risk
Hyperkalemia in patients with chronic kidney disease (CKD) stage 3 or 4 more than doubles their risk of progressing to CKD stage 5, a study found.
Patiromer Enables Longer Spironolactone Use in Advanced CKD
In a study of patients with advanced chronic kidney disease and resistant hypertension, a significantly higher proportion of patients taking patiromer vs placebo remained on spironolactone after 12 weeks.
Potassium Abnormalities Up Mortality in the Peritoneal Dialysis Population
In a study of patients on peritoneal dialysis, hyperkalemia was associated with increased risks of all-cause and arrhythmia-related mortality in non-Hispanic blacks and whites, but was not associated with either outcome in Hispanics.
Down-Titration of MRAs Linked to Early Death in Heart Failure
In a study, hospitalized heart failure patients who reduced their dose of mineralocorticoid antagonists due to hyperkalemia had worse survival.
Patiromer Potentially Useful for Acute Hyperkalemia
This real world study examined maximum-dose patiromer in patients with end-stage renal disease and severe hyperkalemia in the emergency department, but the drug’s onset of action remains unclear.
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