Canagliflozin Lowers ESRD Risk in Diabetic Kidney Disease
In a study of patients with type 2 diabetes and chronic kidney disease, canagliflozin, an SGLT2 inhibitor, decreased the risk of end-stage renal disease by 32% compared with placebo.
Hemodialysis
Drug Treats Hyperphosphatemia Without Binding Phosphate
In a phase 3 trial, tenapanor, which reduces paracellular phosphate transport in the intestine, lowered elevated serum phosphorus in patients on hemodialysis.
Spironolactone Has No Effect on LVM in Hemodialysis Patients
Patients treated with the mineralocorticoid receptor antagonist had a higher frequency of moderate hyperkalemia compared with placebo recipients.
Microwave Ablation for SHPT May Offer Alternative to Parathyroidectomy
In a small study of hemodialysis patients with secondary hyperparathyroidism, microwave ablation achieved higher rates of the recommended target levels of intact parathyroid hormone.
Sertraline Outperforms CBT for Depression in Hemodialysis Patients
Sertraline is modestly more effective than cognitive behavioral therapy (CBT) in treating depressive symptoms in patients on maintenance hemodialysis (HD), new study findings suggest. The study, led by Rajnish Mehrotra, MD, MS, of the Kidney Research Institute at the University of Washington in Seattle, also found that engagement interviews had no effect on patient acceptance…
Dialysis and Transplant Patients at Increased Risk for Cancer Death
Dialysis patients were more likely to die from pre-existing cancers and transplant recipients from de novo cancers.
Clues to Spontaneous Resolution of Anemia in Hemodialysis Found
Restoration of iron homeostasis and normal hepcidin levels appears to play a key role in freeing hemodialysis patients from having to receive erythropoiesis-stimulating agents.
Anemia Severity Linked to LVH Risk in Pediatric Dialysis
Time-averaged hemoglobin levels, not hemoglobin cycling, is associated with an increased risk of left ventricular hypertrophy in pediatric dialysis patients, a study found.
Predialysis Nephrology Care Associated With Lower AFib Risk
Older patients who had more frequent nephrology visits prior to initiating dialysis had a lower incidence of atrial fibrillation in the year after initiating dialysis compared with those who did not.
Most Disliked Dialysis Dietary Restriction Is Limited Fluid Intake
In a survey, nearly one-third of hemodialysis patients said they disliked fluid restriction.
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