Finerenone NDA Submitted for Diabetic Kidney Disease
The NDA for finerenone is supported by data from the double-blind, placebo-controlled phase 3 FIDELIO-DKD trial.
Diabetic Nephropathy
Highlights From the New KDIGO Guideline on Diabetes and CKD
The new KDIGO guideline highlights specific management differences by CKD severity.
Patients With Diabetes and CVD on Empagliflozin Have Fewer CV, Renal Events
Researchers assessed the risk for obstructive sleep apnea (OSA) among patients with type 2 diabetes and cardiovascular disease taking empagliflozin and further examined the effect of OSA on metabolic, cardiovascular, and renal outcomes.
Efficacy of Endothelin Receptor Antagonists for Renal Protection in Diabetic Kidney Disease
Atrasentan outperformed both avosentan and bosentan for renoprotection in patients with type 2 diabetic kidney disease.
Dapagliflozin Gets Breakthrough Therapy Status for CKD Indication
The designation was granted based on results from the phase 3 DAPA-CKD trial, which was stopped early due to “overwhelming efficacy”.
Updated ADA Guideline Recommends Combo Tx for Type 2 Diabetes With CKD
The 2020 ADA guideline update reflects evidence from recent major trials with cardiovascular and renal outcomes.
Dapagliflozin Reduces Kidney Failure Risk, Prolongs Survival in CKD
Dapagliflozin appears to preserve kidney function and improve survival in patients with chronic kidney disease whether or not they have type 2 diabetes.
Empagliflozin Beneficial in Heart Failure With Reduced Ejection Fraction
In a trial, empagliflozin reduced the risks for heart failure hospitalization and renal outcomes in patients with heart failure with reduced ejection fraction.
Boxed Warning Removed From Canagliflozin Labeling
The FDA concluded “the risk no longer meets the standard for a Boxed Warning.”
Trial Investigating Dapagliflozin in CKD Meets All End Points
The multicenter, event-driven, double-blind, placebo-controlled trial compared the effect of dapagliflozin to placebo on renal outcomes and cardiovascular mortality in patients with CKD.
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