Allopurinol May Reduce Contrast Nephropathy in CKD Population
Previous research suggested that allopurinol, a xanthine oxidase inhibitor, prevents the formation of oxygen-free radicals that may contribute to contrast nephropathy.
Contrast Nephropathy
Gadavist Imaging Bulk Package Approved for Multi-Patient Dosing
Gadavist® Imaging Bulk Package is supplied as 604.72mg/mL of gadobutrol in 30mL and 65mL multidose containers.
Recommendations for Use of IV Iodinated Contrast Media Updated
Radiologists and clinicians should weigh the relative benefits and risks of using IV contrast in patients with eGFRs less than 30 mL/min/1.73 m2, according to a consensus statement.
Renal Outcomes Not Worsened by Omitting Hydration Prior to Contrast-Enhanced CT
Withholding prehydration with sodium bicarbonate from patients with CKD stage 3 undergoing nonemergent contrast-enhanced computed tomography does not compromise renal safety, a study found.
Data Support Group II Gadolinium-Based Contrast Use in Advanced Kidney Disease
The potential diagnostic harms of withholding group II gadolinium-based contrast agents may outweigh the risk of nephrogenic systemic fibrosis in advanced CKD patients, according to investigators.
Gadolinium-Based Contrast May Up Acute Kidney Injury Risk in CKD
The risk of post-contrast acute kidney injury increased with decreasing renal function.
Ultra-low Contrast Volume May Protect Kidneys in Advanced CKD
No patient had a 25% or greater rise in serum creatinine 48 hours after receiving a median 13 mL of contrast for diagnostic coronary angiography, with an additional 13 mL for percutaneous coronary intervention.
Nicorandil May Prevent Contrast-induced Nephropathy
Nicorandil significantly reduced contrast-induced nephropathy by 62%, compared with controls.
IV Sodium Bicarbonate Does Not Reduce AKI Risk After Angiography
Contrast-associated acute kidney injury occurred in 9.5% and 9.1% of patients receiving IV sodium bicarbonate and acetylcysteine, respectively, rates which did not differ significantly from the 8.3% rate among those receiving IV sodium chloride.
AKI More Likely After Intracoronary Versus IV Contrast Delivery
In a phase 3 trial, acute kidney injury developed in 13.2% of patients undergoing invasive coronary angiography compared with 5.6% of those undergoing computed tomography angiography.
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