Searching for Surrogates: The Effort to Speed Up Drug Trials
Surrogate endpoints can substantially shorten clinical trials and expedite approvals of new drugs, but they are elusive and sometimes controversial.
Diagnosis & Disease Information
Study Supports Total GFR Slope as a Surrogate Endpoint in Clinical Trials
Meta-analysis demonstrates that treatment effect on total GFR slope strongly predicts clinical endpoints.
Avacopan’s Superiority for ANCA-Associated Vasculitis Persists Despite Low eGFR
Investigators conducted a subgroup analysis of patients with eGFR values of 20 mL/min/1.73 m2 or less in the phase 3 ADVOCATE trial.
Addressing the Lack of Diversity in Cancer Clinical Trials
Experts discuss the challenges and potential resolutions for increasing diversity of clinical trial study populations.
Less Than Half of US-Based Clinical Trials Report Race/Ethnicity
Median combined enrollment of minority race/ethnicity groups was below corresponding population demographics based on census estimates
Reasons for Cancer Clinical Trial Withdrawal Often Not Understood
A structured interview study sought to understand patient experiences after being withdrawn from a cancer clinical trial.
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