Chronic Kidney Disease

Anthony J. Bleyer, MD, MS

Genetic Renal Disease Easily Missed

Autosomal dominant interstitial kidney disease is an under-recognized cause of kidney failure. Characterized by a very strong family history of kidney disease, it is a slowly progressive condition that leads to dialysis when patients are in their 40s or older.

Ergocalciferol Benefits CKD Patients

Ergocalciferol supplementation in CKD patients can safely raise levels of serum 25-hydroxyvitamin (OH) D levels and decrease serum intact parathyroid hormone (iPTH) levels, especially in patients with stage 4 renal disease.

Better CIN Protection?

CHICAGO—N-acetylcysteine (NAC) may be superior to ascorbic acid in preventing contrast-induced nephropathy (CIN) in patients with renal insufficiency, Korean researchers reported here at the American Heart Association annual scientific sessions.

Proteinuria A Useful Measure in Kids

As with adults, proteinuria reflects CKD severity in children, according to researchers. Their study of 213 children with mild to moderate CKD revealed that proteinuria correlates with glomerular filtration rate (GFR), regardless of CKD cause or other factors.

No Marker IDs Nonresponders to IV Iron

SAN DIEGO—No baseline transferrin saturation (TSAT), serum ferritin, or soluble transferrin receptor value predicts how hemodialysis patients with high ferritin levels will respond to IV iron therapy.

Crescents In Renal Biopsies A Bad Sign

WASHINGTON, D.C.—Class IV patients with diffuse lupus glomerulonephritis with crescents may require more aggressive therapy directed at non-immune complex mediated necrotizing glomerulonephritis compared to patients without crescents, according to a new study.

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