Secondary Hyperparathyroidism

Cinacalcet May Delay Surgery for Secondary Hyperparathyroidism

Cinacalcet May Delay Surgery for Secondary Hyperparathyroidism

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Parathyroid gland volume more than halved in patients treated with cinacalcet for 8 years.

Cinacalcet May Help Relieve Calciphylaxis

Cinacalcet May Help Relieve Calciphylaxis

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Using cinacalcet in combination with other therapies may be even more efficacious, according to results from a new review.

Peritoneal Dialysis Superior for Easing Post-PTx Hungry Bone Syndrome

Peritoneal Dialysis Superior for Easing Post-PTx Hungry Bone Syndrome

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Findings from a small study suggest that patients on peritoneal dialysis who have hungry bone syndrome respond better to treatment than those on hemodialysis.

SGLT2 Inhibitor Increases Serum Phosphate, PTH, and FGF23

SGLT2 Inhibitor Increases Serum Phosphate, PTH, and FGF23

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Study supports the hypothesis that altered tubular phosphate handling drives the increase in serum phosphate during SGLT2 inhibition.

Genetic Variant in FGF23 Tied With Cardiovascular Risks in HD

Genetic Variant in FGF23 Tied With Cardiovascular Risks in HD

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In a study, having the single nucleotide polymorphism rs11063112 in fibroblast growth factor 23 was associated with a 32% greater risk for cardiovascular mortality.

Active Vitamin D Therapy Prolongs Survival in Hemodialysis

Active Vitamin D Therapy Prolongs Survival in Hemodialysis

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In a study of hemodialysis patients, vitamin D users had a lower mortality rate than nonusers: 9 vs 13 per 100 person-years.

Effect of Payment Bundling on Calcimimetic Use Still Unclear

Effect of Payment Bundling on Calcimimetic Use Still Unclear

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Younger age, longer dialysis vintage, and black race are associated with greater cinacalcet prescribing in the United States.

Parathyroidectomy-Associated Hyperkalemia Common in HD Patients

Parathyroidectomy-Associated Hyperkalemia Common in HD Patients

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Hyperkalemia developed in nearly 67% of hemodialysis patients during or immediately following total parathyroidectomy with autotransplantation for secondary hyperparathyroidism.

Cinacalcet Appears Safe, Effective for Children With SHPT

Cinacalcet Appears Safe, Effective for Children With SHPT

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In a small study, more than half of pediatric patients receiving cinacalcet experienced a 30% or greater decline in mean intact parathyroid hormone.

Cardiovascular Event Risk Higher With Total Parathyroidectomy

Cardiovascular Event Risk Higher With Total Parathyroidectomy

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Patients who underwent subtotal vs total parathyroidectomy had half the risk for cardiovascular events.

Parathyroidectomy for SHPT Reduces Aortic Calcification

Parathyroidectomy for SHPT Reduces Aortic Calcification

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In a small study of hemodialysis patients with secondary hyperparathyroidism, abdominal aortic calcification decreased more in patients who underwent parathyroidectomy than in those in a control group over 1 year.

VDRAs Do Not Lower Cardiovascular Event Risk in HD

VDRAs Do Not Lower Cardiovascular Event Risk in HD

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Trial results do not support use of vitamin D receptor activators to prevent cardiovascular events in patients with end-stage renal disease and low intact parathyroid hormone levels.

Etelcalcetide Found to Increase Bone Mineral Density in SHPT

Etelcalcetide Found to Increase Bone Mineral Density in SHPT

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Markers of bone resorption decreased in hemodialysis patients with 6 months of etelcalcetide treatment.

Ankle-Brachial Index Predicts Vascular Calcification in SHPT

Ankle-Brachial Index Predicts Vascular Calcification in SHPT

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Analyses demonstrated that an ABI of 1.79 correlated with radiographic evidence of calcified vessels.

Thrice-Weekly Calcimimetic Dosing Feasible for SHPT

Thrice-Weekly Calcimimetic Dosing Feasible for SHPT

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In a study, patients receiving cinacalcet under supervision 3 times per week after dialysis rather than after daily self-administration showed improvement in their parathyroid hormone levels.

Etelcalcetide Beneficial in Severe SHPT Uncontrolled With Cinacalcet

Etelcalcetide Beneficial in Severe SHPT Uncontrolled With Cinacalcet

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In a study, patients with uncontrolled SHPT were switched from oral cinacalcet to intravenous etelcalcetide.

Predictors of SHPT Progression in CKD Identified

Predictors of SHPT Progression in CKD Identified

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Loss of renal function may not be the sole factor in SHPT development, according to new study findings.

Racial Differences Observed in Pediatric SHPT

Racial Differences Observed in Pediatric SHPT

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According to a study, black youth on dialysis have higher parathyroid hormone levels than white youth.

Cinacalcet Eases Refractory SHPT in Young Children

Cinacalcet Eases Refractory SHPT in Young Children

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In a case series of 10 pediatric patients, goal iPTH was attained over a median 6 months.

Ascorbic Acid Ineffective for CKD-MBD

Ascorbic Acid Ineffective for CKD-MBD

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Despite promising early research, the vitamin C did not improve mineral abnormalities over the long term.

Mineral Abnormalities Linked With Increased Mortality

Mineral Abnormalities Linked With Increased Mortality

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In a study, patients with hypercalcemia had the highest risk for premature death.

High PTH Linked to Reduced Lumbar Bone Mineral Density

High PTH Linked to Reduced Lumbar Bone Mineral Density

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Secondary hyperparathyroidism in postmenopausal women with vitamin D insufficiency is associated with lower weight-adjusted bone mineral density in the lumbar spine.

Parathyroidectomy Found to Up Bone Density in SHPT

Parathyroidectomy Found to Up Bone Density in SHPT

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In a small study, total parathyroidectomy without autotransplantation improved bone mineral density in the lumbar spine and hip in ESRD patients with secondary hyperparathyroidism.

Cinacalcet Cessation Associated With Increases in PTH, Calcium

Cinacalcet Cessation Associated With Increases in PTH, Calcium

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Researchers examined the effects of the end of public funding for the medication in Australia.

Vitamin D Stores Lower in the Obese, Overweight

Vitamin D Stores Lower in the Obese, Overweight

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Obese or overweight individuals have significantly lower levels of 25-hydroxyvitamin D than normal-weight individuals at any level of kidney function, a study found.

Parathyroidectomy for Secondary Hyperparathyroidism Improves Outcomes

Parathyroidectomy for Secondary Hyperparathyroidism Improves Outcomes

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Surgical procedure can correct calcium and phosphorus abnormalities and improve coronary artery calcification, study finds.

SHPT May Contribute to Protein-Energy Wasting in HD

SHPT May Contribute to Protein-Energy Wasting in HD

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Protein-energy wasting is characterized by undernutrition unrelieved by nutritional therapy and increased fat and protein catabolism.

Cinacalcet Withdrawal Linked With PTH, Calcium Rise

Cinacalcet Withdrawal Linked With PTH, Calcium Rise

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Serum parathyroid hormone levels significantly increased from 42.2 to 114.8 pmol/L over 12 months in patients who halted the calcimimetic drug.

Post-Parathyroidectomy Hypocalcemia Risk Factors Identified

Post-Parathyroidectomy Hypocalcemia Risk Factors Identified

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Pre-operative parathyroid hormone and calcium levels and pruritus are significantly associated with development of severe hypocalemia.

Reducing PTH Might Improve Anemia in Hemodialysis

Reducing PTH Might Improve Anemia in Hemodialysis

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Anemia control may be one more reason to treat elevated parathyroid hormone levels.

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