Secondary Hyperparathyroidism

SHPT May Contribute to Protein-Energy Wasting in HD

SHPT May Contribute to Protein-Energy Wasting in HD

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Protein-energy wasting is characterized by undernutrition unrelieved by nutritional therapy and increased fat and protein catabolism.

Cinacalcet Withdrawal Linked With PTH, Calcium Rise

Cinacalcet Withdrawal Linked With PTH, Calcium Rise

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Serum parathyroid hormone levels significantly increased from 42.2 to 114.8 pmol/L over 12 months in patients who halted the calcimimetic drug.

Post-Parathyroidectomy Hypocalcemia Risk Factors Identified

Post-Parathyroidectomy Hypocalcemia Risk Factors Identified

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Pre-operative parathyroid hormone and calcium levels and pruritus are significantly associated with development of severe hypocalemia.

Reducing PTH Might Improve Anemia in Hemodialysis

Reducing PTH Might Improve Anemia in Hemodialysis

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Anemia control may be one more reason to treat elevated parathyroid hormone levels.

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

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Predictors of hungry bone syndrome after parathyroidectomy include lower pre- and post-op calcium levels, according to a new study.

Cinacalcet Administration After Hemodialysis Safe, Effective

Cinacalcet Administration After Hemodialysis Safe, Effective

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Control of parathyroid hormone did not differ markedly at 48 and 72 hours after in-center HD compared with 24 hours after daily oral administration of 30 mg cinacalcet.

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

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Levels of the bone turnover markers CTX and P1NP declined over approximately 6 months of treatment patients with CKD and secondary hyperparathyroidism.

Vitamin D3 and D2 Similarly Effective for SHPT in CKD

Vitamin D3 and D2 Similarly Effective for SHPT in CKD

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Researchers found no significant difference between ergocalciferol and cholecalciferol in maintaining levels of vitamin D, parathyroid hormone, and calcium.

Parathyroidectomy Reasonable for Refractory SHPT

Parathyroidectomy Reasonable for Refractory SHPT

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The authors of a new review suggest more dialysis patients could benefit from parathyroidectomy.

Intensive Phosphorus-Lowering May Reduce PTH

Intensive Phosphorus-Lowering May Reduce PTH

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In a study, intact parathyroid hormone levels fell by nearly 10% over 6 months in hemodialysis patients who received intensive treatment for hyperphosphatemia.

CKD-MBD Guideline Synopsis Issued

CKD-MBD Guideline Synopsis Issued

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Panel focuses on diagnosing and testing of CKD-MBD and treatment of the CKD-MBD that emphasizes decreasing phosphate, maintaining calcium, and addressing elevated PTH in adults with CKD stage G3a to G5.

Coronary Artery Calcification Risk Factors in CKD Identified

Coronary Artery Calcification Risk Factors in CKD Identified

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Abnormal calcium-phosphate metabolism appears to be an important pathogenic factor in the development of vascular calcification in patients with chronic kidney disease.

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

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In patients with stage 5 chronic kidney disease, lupus anticoagulant and combined thrombophilia occur more frequently in those with versus without calciphylaxis, case-control study shows.

SHPT May Predict Left Ventricular Diastolic Dysfunction

SHPT May Predict Left Ventricular Diastolic Dysfunction

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iPTH significantly correlated with measures of diastolic dysfunction in patients with non-dialysis chronic kidney disease.

Post-Parathyroidectomy Calcium Requirement Linked to Preop ALP

Post-Parathyroidectomy Calcium Requirement Linked to Preop ALP

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Patients with high alkaline phosphatase prior to PTx should be treated aggressively after surgery to prevent postoperative hypocalcemia, researchers conclude.

PTH After Parathyroidectomy Indicates 5-Year PTH Outcomes

PTH After Parathyroidectomy Indicates 5-Year PTH Outcomes

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In 2 studies, parathyroid hormone (PTH) values 20 minutes after parathyroidectomy predicted PTH levels for 5 years.

High, Low Values of CKD-MBD Markers Linked With Mortality

High, Low Values of CKD-MBD Markers Linked With Mortality

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In a study, intact parathyroid hormone levels below 60 and above 1500 pg/mL were associated with nearly double the risk of all-cause mortality.

Ethanol Ablation Therapy Feasible for SHPT

Ethanol Ablation Therapy Feasible for SHPT

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In a small study, more than half of patients with secondary hyperparathyroidism had a greater than 25% drop in parathyroid hormone levels following ethanol injection therapy.

SHPT Highly Prevalent Among Diabetic Nephropathy Patients

SHPT Highly Prevalent Among Diabetic Nephropathy Patients

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Nearly 86% of diabetic nephropathy patients from an Egyptian outpatient center had elevated iPTH levels.

Hypocalcemia Common After Cinacalcet Initiation

Hypocalcemia Common After Cinacalcet Initiation

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Hypocalcemia developed in 58.3% of study participants within the first 16 weeks and, in most cases, resolved within 14 days with no changes in treatment.

Parathyroidectomy for SHPT Improves Quality of Life

Parathyroidectomy for SHPT Improves Quality of Life

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Patients reported less skin itching, joint pain, and muscle weakness after surgery.

Parathyroidectomy May Improve SHPT Patient Survival

Parathyroidectomy May Improve SHPT Patient Survival

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ESRD patients with SHPT undergoing surgery had a 26% lower risk for all-cause mortality compared with medical management.

Elevated PTH Tied to Arteriovenous Fistula Maturation Failure

Elevated PTH Tied to Arteriovenous Fistula Maturation Failure

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Secondary hyperparathyroidism may have a detrimental effect on successful arteriovenous fistula creation, researcher says.

Etelcalcetide Injection Into Parathyroid Glands Safe

Etelcalcetide Injection Into Parathyroid Glands Safe

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In a pilot study, investigators observed no harmful effects from etelcalcetide injection, and 5 of 10 of patients had a greater than 50% decline in PTH levels.

Paricalcitol May Be More Efficacious Than Cinacalcet in HD

Paricalcitol May Be More Efficacious Than Cinacalcet in HD

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Therapy with paricalcitol alone achieved the greatest decline in intact parathyroid hormone among hemodialysis with secondary hyperparathyroidism.

Biomarkers Predict Renal Function Decline, CV Events

Biomarkers Predict Renal Function Decline, CV Events

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High levels of parathyroid hormone and fibroblast growth factor 23 in CKD patients are associated with need for renal replacement therapy or a 50% or greater decline in eGFR.

No iPTH Oversuppression With Extended-Release Calcifediol

No iPTH Oversuppression With Extended-Release Calcifediol

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Intact parathyroid hormone levels decline in proportion with SHPT severity in patients taking the drug.

Vitamin D Supplementation Improves PTH, Bone Turnover in CKD

Vitamin D Supplementation Improves PTH, Bone Turnover in CKD

Cholecalciferol can also correct vitamin D deficiency in patients with chronic kidney disease.

Low Protein Diet With Keto Analogues May Prevent SHPT

Low Protein Diet With Keto Analogues May Prevent SHPT

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Dialysis patients treated with a low protein diet with keto analogues had lower levels of parathyroid hormone than those on a normal diet, meta-analysis shows.

IV Calcimimetic Benefits Hemodialysis Patients With SHPT

IV Calcimimetic Benefits Hemodialysis Patients With SHPT

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By the third month of treatment, 59% of etelcalcetide recipients had reached target iPTH levels of 60 to 240 pg/mL compared with just 1.3% of placebo recipients.

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