Secondary Hyperparathyroidism

VDRAs Do Not Lower Cardiovascular Event Risk in HD

VDRAs Do Not Lower Cardiovascular Event Risk in HD

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Trial results do not support use of vitamin D receptor activators to prevent cardiovascular events in patients with end-stage renal disease and low intact parathyroid hormone levels.

Etelcalcetide Found to Increase Bone Mineral Density in SHPT

Etelcalcetide Found to Increase Bone Mineral Density in SHPT

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Markers of bone resorption decreased in hemodialysis patients with 6 months of etelcalcetide treatment.

Ankle-Brachial Index Predicts Vascular Calcification in SHPT

Ankle-Brachial Index Predicts Vascular Calcification in SHPT

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Analyses demonstrated that an ABI of 1.79 correlated with radiographic evidence of calcified vessels.

Thrice-Weekly Calcimimetic Dosing Feasible for SHPT

Thrice-Weekly Calcimimetic Dosing Feasible for SHPT

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In a study, patients receiving cinacalcet under supervision 3 times per week after dialysis rather than after daily self-administration showed improvement in their parathyroid hormone levels.

Etelcalcetide Beneficial in Severe SHPT Uncontrolled With Cinacalcet

Etelcalcetide Beneficial in Severe SHPT Uncontrolled With Cinacalcet

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In a study, patients with uncontrolled SHPT were switched from oral cinacalcet to intravenous etelcalcetide.

Predictors of SHPT Progression in CKD Identified

Predictors of SHPT Progression in CKD Identified

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Loss of renal function may not be the sole factor in SHPT development, according to new study findings.

Racial Differences Observed in Pediatric SHPT

Racial Differences Observed in Pediatric SHPT

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According to a study, black youth on dialysis have higher parathyroid hormone levels than white youth.

Cinacalcet Eases Refractory SHPT in Young Children

Cinacalcet Eases Refractory SHPT in Young Children

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In a case series of 10 pediatric patients, goal iPTH was attained over a median 6 months.

Ascorbic Acid Ineffective for CKD-MBD

Ascorbic Acid Ineffective for CKD-MBD

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Despite promising early research, the vitamin C did not improve mineral abnormalities over the long term.

Mineral Abnormalities Linked With Increased Mortality

Mineral Abnormalities Linked With Increased Mortality

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In a study, patients with hypercalcemia had the highest risk for premature death.

High PTH Linked to Reduced Lumbar Bone Mineral Density

High PTH Linked to Reduced Lumbar Bone Mineral Density

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Secondary hyperparathyroidism in postmenopausal women with vitamin D insufficiency is associated with lower weight-adjusted bone mineral density in the lumbar spine.

Parathyroidectomy Found to Up Bone Density in SHPT

Parathyroidectomy Found to Up Bone Density in SHPT

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In a small study, total parathyroidectomy without autotransplantation improved bone mineral density in the lumbar spine and hip in ESRD patients with secondary hyperparathyroidism.

Cinacalcet Cessation Associated With Increases in PTH, Calcium

Cinacalcet Cessation Associated With Increases in PTH, Calcium

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Researchers examined the effects of the end of public funding for the medication in Australia.

Vitamin D Stores Lower in the Obese, Overweight

Vitamin D Stores Lower in the Obese, Overweight

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Obese or overweight individuals have significantly lower levels of 25-hydroxyvitamin D than normal-weight individuals at any level of kidney function, a study found.

Parathyroidectomy for Secondary Hyperparathyroidism Improves Outcomes

Parathyroidectomy for Secondary Hyperparathyroidism Improves Outcomes

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Surgical procedure can correct calcium and phosphorus abnormalities and improve coronary artery calcification, study finds.

SHPT May Contribute to Protein-Energy Wasting in HD

SHPT May Contribute to Protein-Energy Wasting in HD

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Protein-energy wasting is characterized by undernutrition unrelieved by nutritional therapy and increased fat and protein catabolism.

Cinacalcet Withdrawal Linked With PTH, Calcium Rise

Cinacalcet Withdrawal Linked With PTH, Calcium Rise

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Serum parathyroid hormone levels significantly increased from 42.2 to 114.8 pmol/L over 12 months in patients who halted the calcimimetic drug.

Post-Parathyroidectomy Hypocalcemia Risk Factors Identified

Post-Parathyroidectomy Hypocalcemia Risk Factors Identified

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Pre-operative parathyroid hormone and calcium levels and pruritus are significantly associated with development of severe hypocalemia.

Reducing PTH Might Improve Anemia in Hemodialysis

Reducing PTH Might Improve Anemia in Hemodialysis

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Anemia control may be one more reason to treat elevated parathyroid hormone levels.

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

Post-Parathyroidectomy Predictors of Hungry Bone Syndrome Identified

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Predictors of hungry bone syndrome after parathyroidectomy include lower pre- and post-op calcium levels, according to a new study.

Cinacalcet Administration After Hemodialysis Safe, Effective

Cinacalcet Administration After Hemodialysis Safe, Effective

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Control of parathyroid hormone did not differ markedly at 48 and 72 hours after in-center HD compared with 24 hours after daily oral administration of 30 mg cinacalcet.

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

Extended-Release Calcifediol Reduces Bone Turnover in SHPT

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Levels of the bone turnover markers CTX and P1NP declined over approximately 6 months of treatment patients with CKD and secondary hyperparathyroidism.

Vitamin D3 and D2 Similarly Effective for SHPT in CKD

Vitamin D3 and D2 Similarly Effective for SHPT in CKD

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Researchers found no significant difference between ergocalciferol and cholecalciferol in maintaining levels of vitamin D, parathyroid hormone, and calcium.

Parathyroidectomy Reasonable for Refractory SHPT

Parathyroidectomy Reasonable for Refractory SHPT

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The authors of a new review suggest more dialysis patients could benefit from parathyroidectomy.

Intensive Phosphorus-Lowering May Reduce PTH

Intensive Phosphorus-Lowering May Reduce PTH

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In a study, intact parathyroid hormone levels fell by nearly 10% over 6 months in hemodialysis patients who received intensive treatment for hyperphosphatemia.

CKD-MBD Guideline Synopsis Issued

CKD-MBD Guideline Synopsis Issued

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Panel focuses on diagnosing and testing of CKD-MBD and treatment of the CKD-MBD that emphasizes decreasing phosphate, maintaining calcium, and addressing elevated PTH in adults with CKD stage G3a to G5.

Coronary Artery Calcification Risk Factors in CKD Identified

Coronary Artery Calcification Risk Factors in CKD Identified

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Abnormal calcium-phosphate metabolism appears to be an important pathogenic factor in the development of vascular calcification in patients with chronic kidney disease.

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

Calciphylaxis in CKD Patients Linked to Hypercoagulable Conditions

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In patients with stage 5 chronic kidney disease, lupus anticoagulant and combined thrombophilia occur more frequently in those with versus without calciphylaxis, case-control study shows.

SHPT May Predict Left Ventricular Diastolic Dysfunction

SHPT May Predict Left Ventricular Diastolic Dysfunction

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iPTH significantly correlated with measures of diastolic dysfunction in patients with non-dialysis chronic kidney disease.

Post-Parathyroidectomy Calcium Requirement Linked to Preop ALP

Post-Parathyroidectomy Calcium Requirement Linked to Preop ALP

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Patients with high alkaline phosphatase prior to PTx should be treated aggressively after surgery to prevent postoperative hypocalcemia, researchers conclude.

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