Higher PTH Levels May Increase Risk of Dialyzer Clotting
Each 100 pg/mL increase in parathyroid hormone was associated with 2-fold increased odds of clotting.
CHICAGO—Parathyroid hormone (PTH) levels may affect the risk of dialyzer clotting, according to a study.
Kyohei Ogawa, MD, of Ashikaga Red Cross Hospital in Ashikaga, Japan, and collaborators studied all outpatient dialysis sessions at Ashikaga Red Cross Hospital in 2015. Out of 4,207 dialysis sessions among 36 patients, the researchers observed significant dialyzer clotting—defined as blood remaining in more than 10 hollow fibers at the end of each dialysis session—in 144 sessions (3.4%), the investigators reported in a poster presentation at the American Society of Nephrology's 2016 Kidney Week conference. The investigators observed a significant interaction between PTH and alkaline phosphatase (ALP), so they stratified patients according to median ALP levels, with 2,094 sessions placed into a low ALP group and 2,113 sessions into a high ALP group. After adjusting for hemoglobin, albumin and APTT, PTH was associated with the risk of clotting in the low ALP group, with each 100 pg/mL increment of intact PTH associated with a significant 2-fold increased odds of clotting. The researchers did not observe the association in the high ALP group. PTH levels were proportional to HDL-cholesterol levels in the high ALP group but inversely proportional in the low ALP group.
Ogawa K, Hirano K, Yamamoto I, et al. Parathyroid hormone as a novel risk factor of hemodialyzer clotting. Data presented in a poster at the American Society of Nephrology 2016 Kidney Week meeting in Chicago, November 16-20. Poster FR-PO968.