Generic Name and Formulations:
Reteplase 10.4Units (18.1mg); per vial; lyophilized pwd for IV inj after reconstitution; preservative-free.
Chiesi USA, Inc.
Indications for RETAVASE:
Management of acute myocardial infarction (AMI) to improve ventricular function and to reduce the incidence of congestive heart failure and mortality.
Start as soon as possible after onset of AMI symptoms. 10Units as IV bolus over 2 minutes; repeat dose 30 minutes after initiation of 1st bolus.
Active internal bleeding. History of cerebrovascular accident. Recent intracranial or intraspinal surgery or trauma. Intracranial neoplasm, arteriovenous malformation, or aneurysm. Bleeding diathesis. Severe uncontrolled hypertension.
Avoid noncompressible arterial puncture, internal jugular and subclavian venous punctures, IM inj, nonessential handling of patient to minimize risk of bleeding. Discontinue concomitant anticoagulant therapy if severe bleeding occurs. Recent major surgery. Cerebrovascular disease. GI or GU bleeding. Hypertension. Left heart thrombus. Acute pericarditis. Subacute bacterial endocarditis. Hemostatic defects. Severe hepatic or renal dysfunction. Hemorrhagic ophthalmic conditions. Septic thrombophlebitis. Occluded AV cannula. Elderly. Pregnancy (Cat.C). Nursing mothers.
Tissue plasminogen activator (tPA).
Bleeding risks increased with heparin, vitamin K antagonists, aspirin, dipyridamole, abciximab. Coagulation tests may be unreliable during therapy.
Bleeding, hypersensitivity reactions, GI upset, hypotension, fever; cardiogenic shock, arrhythmias, AV block, pulmonary edema, heart failure, cardiac arrest, ischemia, reinfarction, myocardial rupture, mitral regurgitation, pericardial effusion, pericarditis, cardiac tamponade, venous thrombosis, cholesterol embolism, electromechanical dissociation.
Kit—1 (2 vials w. diluents, supplies)
Half-Kit—1 (1 vial w. diluent)
Renal and Urology News Articles
- Acute Renal Failure in CKD Patients Less Likely With PCI
- Gout Associated With Increased Risk of Developing Erectile Dysfunction
- The Potential Role for PARP Inhibitors in Prostate Cancer
- More Targeted Sodium Reduction Strategies Proposed
- Cytoreductive Surgery for Metastatic PCa Linked to More Complications
- FDA Recalls Drugs Containing Active Ingredient Valsartan
- Correcting Metabolic Acidosis May Preserve Muscle Mass
- Infection Risk Lower in Dialysis Patients With High, Normal Vitamin D
- Urine Cytology May Not Improve Hematuria Evaluation for Bladder Cancer
- Aggressive Therapy Warranted for Gleason 10 Prostate Cancer
Sign Up for Free e-newsletters
NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)