Renal Replacement Therapy
Early and delayed renal-replacement therapy for septic shock associated acute kidney injury show similar mortality: the IDEAL-ICU trialOctober 17, 2018
1. Among patients with septic shock and acute kidney injury (AKI), there was no significant difference in 90-day mortality between early (within 12 hours) and delayed (after 48 hours) initiation of renal-replacement therapy (RRT). 2. Patients in the delayed group had significantly more days free from RRT, with no significant differences compared to the early 
More than half of patients died prematurely, regardless of whether they received early or delayed RRT.
Evidence to date provides no clear answer as to whether early or delayed RRT is the best approach.
The initiation of RRT has a strong impact on HRQL in comparison with a reference population and with other stages of CKD.
Septic shock patients randomized to receive thiamine had lower serum creatinine levels and a lower rate of progression to RRT than patients randomized to placebo.
The researchers found that stage 2 acute kidney injury was associated with increased risk of delirium and coma as was stage 3 acute kidney injury.
The condition also is associated with greater use of renal-replacement therapy and mechanical ventilation.
It also may shorten intensive care unit and hospital length of stay versus late RRT in critically ill patients, meta-analysis reveals.
Japanese study demonstrates a 2-fold increased risk of death from any cause.
High FiO2 and norepinephrine in AKI patients increases their risk of death within 24 hours of being placed on continuous renal replacement therapy.
Study demonstrates improved 90-day survival and greater likelihood of recovering renal function.
Mortality no different for early versus delayed strategy for patients with severe acute kidney injury.
Study finds a 3-folder greater risk of early death within a year of hemodialysis initiation.
Severe hypoglycemia may result in changes in mental state, seizures, arrhythmias, coma, and death.
A low protein diet of vegetable proteins along with reduced intake of specific micronutrients should be recommended to stage 3-4 CKD patients, researchers say.
Risk of developing acute kidney injury similar with buffered crystalloid, saline.
It is associated with a lower risk of adverse renal outcomes compared with midazolam.
A multidisciplinary team-based approach to diabetes management may help prevent complications like diabetic kidney disease.
In a study, 86% of patients who survived experienced renal recovery within 1 year.
In a study, home hemodialysis was associated with a 53% decreased risk of death compared with peritoneal dialysis.
In a study, the incidence of hyperphosphatemia, ionized hypocalcemia, and ionized hypercalcemia was 44%, 22%, and 23%, respectively.
Investigators propose a protocol for when patients should be referred to nephrologists.
New report shows that Montenegro had the lowest rate of renal replacement therapy.
Physicians provided details of the first successful delivery of renal replacement therapy (RRT) to a patient with Ebola.
Researchers find a greater than 50% reduction in end-stage renal disease risk compared with radical nephrectomy.
First in-human use of miniaturized machine shows good outcomes.
In congressional testimony, Sharon M. Moe, MD, proposes a federal prize competition.
More than 60% of patients had died within four years of entry into a clinical trial of different RRT intensities for acute kidney injury.
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- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)