Prostate Cancer

Cancer Screening More Likely After a Previous False Positive

Cancer Screening More Likely After a Previous False Positive

Findings for both men and women with a false-positive prostate or breast cancer test result.

<i>BRCA</i> Mutations Up Risk for PCa, Other Cancers

BRCA Mutations Up Risk for PCa, Other Cancers

Increased incidence of malignant disease, specifically prostate, melanoma, pancreas, breast cancers

Survey Highlights Emotional Responses to Prostate Cancer

Survey Highlights Emotional Responses to Prostate Cancer

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Sexual dysfunction was a chief complaint among survey respondents with prostate cancer.

Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors

Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors

Myocarditis with ICIs may be more common than initially thought; responds to higher steroid dosages

Diet, Exercise With Behavioral Counseling Can Reduce ADT Side Effects

Diet, Exercise With Behavioral Counseling Can Reduce ADT Side Effects

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A novel component of an interventional program was cognitive-behavioral counseling administered in a group setting to promote behavioral change.

More Extensive Lymph Node Dissection in PCa Improves Outcomes

More Extensive Lymph Node Dissection in PCa Improves Outcomes

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Study shows that the risk of recurrence after salvage radiotherapy is inversely related to the number of nodes resected at radical prostatectomy.

Socioeconomics May Not Explain Racial Gap in Prostate Cancer Mortality

Socioeconomics May Not Explain Racial Gap in Prostate Cancer Mortality

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In a study, race independently predicted prostate cancer-specific mortality beyond a number of risk factors, including health insurance status.

Low-Dose Abiraterone Noninferior for Castration-Resistant PCa

Low-Dose Abiraterone Noninferior for Castration-Resistant PCa

Low-dose AA with low-fat breakfast had greater effect on PSA; similar effect to standard dose

Optimal Management of Oligometastatic Prostate Cancer Remains Unclear

Optimal Management of Oligometastatic Prostate Cancer Remains Unclear

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More and more cases of oligometastatic PCa are being diagnosed as a result of advances in molecular imaging, but clinical trial data about the best way to treat this disease entity are lacking.

Adjuvant RT Plus ADT Beneficial in Selected Prostate Cancer Cases

Adjuvant RT Plus ADT Beneficial in Selected Prostate Cancer Cases

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Study identifies which PCa patients with positive lymph nodes may have improved survival with the addition of adjuvant radiotherapy to androgen-deprivation therapy.

Biopsy-to-RP Delay May Up Prostate Cancer Recurrence Risk

Biopsy-to-RP Delay May Up Prostate Cancer Recurrence Risk

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Researchers concluded that a greater than 90-day interval from prostate biopsy to radical prostatectomy increases the risk of biochemical recurrence among men with Gleason 3+4 disease.

Prostate Cancer Survival Metrics: A New Standard?

Prostate Cancer Survival Metrics: A New Standard?

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Effective clinical trial design and ultimately drug approval require careful consideration of the endpoints selected.

Metastatic Prostate Cancer at Diagnosis in Decline

Metastatic Prostate Cancer at Diagnosis in Decline

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Study documents a drop in the incidence of de novo metastatic PCa from 1980 to 2011 in the United States.

Finasteride Cuts Prostate Cancer Risk Long Term

Finasteride Cuts Prostate Cancer Risk Long Term

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New study shows that men are at lower risk of prostate cancer for years after they stop taking the medication.

MRI Scans Can Avert Many Prostate Biopsies

MRI Scans Can Avert Many Prostate Biopsies

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In a large international trial, pre-biopsy MRI scans spared 28% of men from having to undergo a biopsy and resulted in a lower detection of clinically insignificant cancers vs standard biopsy.

Dose-Escalated RT Does Not Improve Survival in Intermediate-Risk PCa

Dose-Escalated RT Does Not Improve Survival in Intermediate-Risk PCa

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Researchers observed reductions in biochemical failure and distant metastasis rates in patients who had dose-escalated radiation therapy.

No Advantages With Aggressive Treatment in Metastatic Prostate Cancer

No Advantages With Aggressive Treatment in Metastatic Prostate Cancer

However, mortality higher with conservative therapy in locally advanced, non-metastatic prostate cancer.

Single PSA Screening Has No Effect on Prostate Cancer Mortality

Single PSA Screening Has No Effect on Prostate Cancer Mortality

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Findings from a large study of men in the United Kingdom do not support single PSA testing for population-based screening.

EBRT+BT+ADT May Be Optimal for High-Grade PCa

EBRT+BT+ADT May Be Optimal for High-Grade PCa

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In a study, extremely dose-escalated radiotherapy combined with androgen deprivation therapy offered the best cancer-specific survival among men with Gleason 9-10 prostate cancer.

State Variation in PSA Screening After the 2011-2012 USPSTF Update

State Variation in PSA Screening After the 2011-2012 USPSTF Update

Not only is there immense state-by-state heterogeneity in PSA screening, but there is also marked variation within each state.

Nocturia May Contribute to Sleep Problems in ADT Recipients

Nocturia May Contribute to Sleep Problems in ADT Recipients

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In a 12-month study, men with prostate cancer treated with ADT reported more nocturia episodes than men with prostate cancer treated with prostatectomy alone and men with no history of cancer.

Prostate Cancer and Your Diet

Prostate Cancer and Your Diet

Research suggests that men's diets can affect their risk for prostate cancer.

MRI May Help Cut Down on Unnecessary Prostate Biopsies

MRI May Help Cut Down on Unnecessary Prostate Biopsies

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Multiparametic MRI findings added to conventional clinical predictors decreases the number of false-positive biopsy results without increasing the number of clinically significant tumors left undiagnosed, study finds.

FDA Oks Drug for Non-metastatic Castration-Resistant Prostate Cancer

FDA Oks Drug for Non-metastatic Castration-Resistant Prostate Cancer

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Apalutamide prolonged metastasis-free survival by 2 years compared with placebo.

Upfront Docetaxel May Have Role in Advanced Prostate Cancer

Upfront Docetaxel May Have Role in Advanced Prostate Cancer

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Added to hormone therapy, docetaxel offers a cost effective way to prolong hormone-sensitive disease and improve quality of life years, especially among men with non-metastatic disease, study finds.

Inclusion Criteria for PCa Trials Inadvertently Exclude Blacks

Inclusion Criteria for PCa Trials Inadvertently Exclude Blacks

Trials sponsored by academic investigators, cooperative groups more likely to use these criteria

Low-Carb Diet Tested as Way to Slow Recurrent Prostate Cancer

Low-Carb Diet Tested as Way to Slow Recurrent Prostate Cancer

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In a small phase 2 study of overweight men with recurrent prostate cancer, consuming less than 20 grams of carbohydrates a day resulted in profound weight loss.

PSA Trajectory in nmCRPC Predicts Metastasis, Mortality Risk

PSA Trajectory in nmCRPC Predicts Metastasis, Mortality Risk

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Metastasis and death are more likely to occur among patients with relatively high PSA levels at diagnosis of nmCRPC and rising PSA levels during follow-up.

Adverse Prostate Cancer Pathology Accurately Predicted With MRI

Adverse Prostate Cancer Pathology Accurately Predicted With MRI

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Multiparametric MRI has high positive and negative predictive values for extracapsular extension, seminal vesicle invasion, lymph node involvement, and high-risk Gleason score.

Urologic Cancer Surgery Readmission Rate Highest for RC

Urologic Cancer Surgery Readmission Rate Highest for RC

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In a study, nearly 20% of radical cystectomy patients were readmitted for complications within 90 days compared with 1.9% and 5.9% for radical prostatectomy and radical nephrectomy, respectively.

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