Prostate Cancer

PCa Phenotype May Predict Response to Immune Checkpoint Blockade

PCa Phenotype May Predict Response to Immune Checkpoint Blockade

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The MSI-H/dMMR phenotype in men with advanced PCa is associated with greater likelihood of a durable response to PD-1/PD-L1 inhibitors.

Suicide Risk Up More Than 4-fold for Cancer Patients

Suicide Risk Up More Than 4-fold for Cancer Patients

Standardized mortality ratio highest for cancers of lung, head and neck, testes, bladder, Hodgkin lymphoma.

Comorbidities Adversely Linked to Cancer Trial Participation

Comorbidities Adversely Linked to Cancer Trial Participation

Reduction in trial discussions, trial offers, trial participation seen with one or more comorbidities.

Younger Men With High-Grade PCa Less Likely to Die After RP Than RT

Younger Men With High-Grade PCa Less Likely to Die After RP Than RT

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Patients younger than age 60 with Gleason 8-10 disease who had upfront surgery versus radiation therapy had a 63% lower risk of prostate cancer-specific mortality.

Early Post-RP Complications Directly Related to Age

Early Post-RP Complications Directly Related to Age

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The risk of virtually all early postoperative complications increases with increasing patient age at radical prostatectomy for localized prostate cancer.

Toxicity From All-Grade AEs in Prostate Cancer Better Reflects QOL

Toxicity From All-Grade AEs in Prostate Cancer Better Reflects QOL

Patient-reported toxicity scores more associated with quality-of-life outcomes than clinician-reported scores.

New Surrogate Marker for ADT Evaluation Proposed

New Surrogate Marker for ADT Evaluation Proposed

Time interval free of biochemical failure may be a potential surrogate end point in the setting of androgen-deprivation therapy evaluation in men with prostate cancer.

Hypofractionated Radiotherapy May Benefit Patients With Localized Prostate Cancer

Hypofractionated Radiotherapy May Benefit Patients With Localized Prostate Cancer

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A study suggests HIMRT may have some advantages over CIMRT for treating men with localized prostate cancer.

Overactive Bladder Linked to Prostate Cancer ADT

Overactive Bladder Linked to Prostate Cancer ADT

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Compared with men receiving androgen deprivation therapy for prostate cancer, healthy men had a 98% decreased risk of overactive bladder, study finds.

Prostate Cancer Possibly Linked to Zinc Intake

Prostate Cancer Possibly Linked to Zinc Intake

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In a Spanish study, the highest vs lowest tertile of dietary zinc intake was associated with a significant 66% increased relative risk of low-grade prostate cancer.

Abiraterone Outcomes Tied to NLR

Abiraterone Outcomes Tied to NLR

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For example, men with a baseline NLR below 2.5, patients who received abiraterone had a significant 28% decreased risk of death.

Prostate Cancer Risk, Aggressiveness Tied to Socioeconomics

Prostate Cancer Risk, Aggressiveness Tied to Socioeconomics

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Study of Canadian men looked at the association between prostate cancer and participants' socioeconomic position during childhood/adolescence and early and late adulthood.

Prostate Cancer Detection Improved With Combined Biopsy Targeting

Prostate Cancer Detection Improved With Combined Biopsy Targeting

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In a study, visual registration in conjunction with image fusion resulted in the highest detection rate of clinically significant prostate cancer.

Gleason 6 Prostate Cancer More Lethal in Black Men

Gleason 6 Prostate Cancer More Lethal in Black Men

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Black men with Gleason 6 prostate cancer had a 1.5- to 2.0-fold increased risk of dying from their cancer compared with nonblack men, according to a new study.

Statins Plus ADT May Up Survival in Advanced Prostate Cancer

Statins Plus ADT May Up Survival in Advanced Prostate Cancer

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Statin use by men receiving androgen deprivation therapy for advanced PCa was associated with decreased risk of overall and cancer-specific mortality.

Radical Prostatectomy Has Lasting Benefit for Localized Cancer

Radical Prostatectomy Has Lasting Benefit for Localized Cancer

Mean 2.9 years gained after 23 years of follow-up among men with localized prostate cancer

Prostate Cancer Linked to Inflammatory Bowel Disease

Prostate Cancer Linked to Inflammatory Bowel Disease

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IBD is associated with a nearly 5-fold increased risk of prostate cancer, study finds.

Testosterone Measurements, TRT Prescribing Infrequent in PCa Care

Testosterone Measurements, TRT Prescribing Infrequent in PCa Care

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More than half of UK specialists surveyed said measuring testosterone levels in patients with nonmetastatic prostate cancer was not their routine practice.

ADT May Be Less Beneficial for Gleason 9 to 10 Prostate Cancer

ADT May Be Less Beneficial for Gleason 9 to 10 Prostate Cancer

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Men with Gleason score 9 to 10 prostate cancer derive no significant survival benefit from androgen deprivation therapy.

Ultrasound + MRI Improves High-Grade Prostate Cancer Detection

Ultrasound + MRI Improves High-Grade Prostate Cancer Detection

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Well demarcated hypoechoic areas in suspicious regions on MRI identify men more likely to have Gleason 7 or higher prostate cancer found on biopsy.

Prostate Cancer Risk Lower in Long-Term Users of Lipid-Lowering Drugs

Prostate Cancer Risk Lower in Long-Term Users of Lipid-Lowering Drugs

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In a study, taking lipid-lowering drugs for 10 or more years was associated with a 32% lower risk prostate cancer.

Delayed Prostate Cancer Treatment May Up Relapse Risk

Delayed Prostate Cancer Treatment May Up Relapse Risk

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Patients whose radical prostatectomy was delayed more than 6 months had a nearly 2-fold increased risk of biochemical recurrence, a study found.

Very High-Risk Prostate Cancer Criteria Validated as a Risk Stratum

Very High-Risk Prostate Cancer Criteria Validated as a Risk Stratum

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Men with very high-risk (VHR) PCa are more likely to have adverse pathologic features and outcomes after radical prostatectomy than those with high-risk but not VHR PCa.

Surgery, Radiation Regimens for High-Grade PCa Offer Similar Outcomes

Surgery, Radiation Regimens for High-Grade PCa Offer Similar Outcomes

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Study compared radical prostatectomy plus adjuvant EBRT or ADT, or both, with a triple combination of EBRT, brachytherapy, and ADT for Gleason score 9-10 prostate cancer.

Salvage Prostatectomy May Benefit Some Prostate Cancer Patients

Salvage Prostatectomy May Benefit Some Prostate Cancer Patients

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Study of men who underwent salvage radical prostatectomy for radiorecurrent prostate cancer found a 10-year rate of biochemical progression-free survival of 33%.

Extraprostatic Extension Indicates Aggressive Prostate Cancer

Extraprostatic Extension Indicates Aggressive Prostate Cancer

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Many patients with extraprostatic extension on biopsy experience biochemical recurrence after surgery and require early multi-modal therapy.

Androgen Deprivation Linked With Heart Failure

Androgen Deprivation Linked With Heart Failure

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In a study, heart failure was nearly twice as likely to develop among ADT recipients compared with non-recipients.

Study: Microarray CCP Scores Not a Substitute for qRT-PCR

Study: Microarray CCP Scores Not a Substitute for qRT-PCR

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Investigators conclude that microarray-generated cell cycle progression score should not be assumed to be a valid surrogate for qRT-PCR-generated scores.

Prostate Cancer Linked to Greater Fat, Fatty Acid Intake

Prostate Cancer Linked to Greater Fat, Fatty Acid Intake

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As stearic acid and total fatty acid intake increased from one quintile to the next, prostate risk increased by 23% and 21%, respectively.

Prostate Cancer Focal Ablation Can Be a Reasonable Option

Prostate Cancer Focal Ablation Can Be a Reasonable Option

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Patient selection and physician-patient commitment to careful follow-up surveillance are key.

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