Prostate Cancer

MRI May Help Cut Down on Unnecessary Prostate Biopsies

MRI May Help Cut Down on Unnecessary Prostate Biopsies

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Multiparametic MRI findings added to conventional clinical predictors decreases the number of false-positive biopsy results without increasing the number of clinically significant tumors left undiagnosed, study finds.

FDA Oks Drug for Non-metastatic Castration-Resistant Prostate Cancer

FDA Oks Drug for Non-metastatic Castration-Resistant Prostate Cancer

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Apalutamide prolonged metastasis-free survival by 2 years compared with placebo.

Upfront Docetaxel May Have Role in Advanced Prostate Cancer

Upfront Docetaxel May Have Role in Advanced Prostate Cancer

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Added to hormone therapy, docetaxel offers a cost effective way to prolong hormone-sensitive disease and improve quality of life years, especially among men with non-metastatic disease, study finds.

Inclusion Criteria for PCa Trials Inadvertently Exclude Blacks

Inclusion Criteria for PCa Trials Inadvertently Exclude Blacks

Trials sponsored by academic investigators, cooperative groups more likely to use these criteria

Low-Carb Diet Tested as Way to Slow Recurrent Prostate Cancer

Low-Carb Diet Tested as Way to Slow Recurrent Prostate Cancer

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In a small phase 2 study of overweight men with recurrent prostate cancer, consuming less than 20 grams of carbohydrates a day resulted in profound weight loss.

PSA Trajectory in nmCRPC Predicts Metastasis, Mortality Risk

PSA Trajectory in nmCRPC Predicts Metastasis, Mortality Risk

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Metastasis and death are more likely to occur among patients with relatively high PSA levels at diagnosis of nmCRPC and rising PSA levels during follow-up.

Adverse Prostate Cancer Pathology Accurately Predicted With MRI

Adverse Prostate Cancer Pathology Accurately Predicted With MRI

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Multiparametric MRI has high positive and negative predictive values for extracapsular extension, seminal vesicle invasion, lymph node involvement, and high-risk Gleason score.

Urologic Cancer Surgery Readmission Rate Highest for RC

Urologic Cancer Surgery Readmission Rate Highest for RC

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In a study, nearly 20% of radical cystectomy patients were readmitted for complications within 90 days compared with 1.9% and 5.9% for radical prostatectomy and radical nephrectomy, respectively.

Early Prostate Cancer Salvage ADT Therapy Better

Early Prostate Cancer Salvage ADT Therapy Better

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Among men who had PSA failure following radiation therapy for localized PCa, those with a long PSA doubling time had an increased risk of PCa mortality if they started androgen-deprivation therapy later.

Prostate Cancer Pathologic Features Worse in Blacks

Prostate Cancer Pathologic Features Worse in Blacks

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Black men undergoing radical prostatectomy for prostate cancer are more likely to have indications for adjuvant radiotherapy compared with white men.

Statin Use May Improve Survival in Advanced Prostate Cancer

Statin Use May Improve Survival in Advanced Prostate Cancer

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Statin use is associated with greater overall survival among men with metastatic castration-resistant prostate cancer and improved survival among patients with high-risk prostate cancer.

Negative Repeat Biopsy in PCa Active Surveillance a Positive Sign

Negative Repeat Biopsy in PCa Active Surveillance a Positive Sign

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In a study, a negative confirmatory prostate biopsy in prostate cancer patients on active surveillance predicts a lower risk of progressing to treatment.

Earlier Prostate Cancer Drug Use in CRPC Cuts Metastasis Risk

Earlier Prostate Cancer Drug Use in CRPC Cuts Metastasis Risk

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In separate studies, apalutamide and enzalutamide prolonged metastasis-free survival in men with non-metastatic castration-resistant prostate cancer.

Testosterone Therapy May Reduce PCa Risk in Hypogonadal Men

Testosterone Therapy May Reduce PCa Risk in Hypogonadal Men

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In a study of hypogonadal men, those who received testosterone therapy had a lower incidence of prostate cancer than those who did not.

Brachytherapy Alone May Be Sufficient for More Risky PCa Cases

Brachytherapy Alone May Be Sufficient for More Risky PCa Cases

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The investigators observed no difference in mortality between BT alone and BT plus ADT and/or EBRT supplemental therapy.

Telementoring Useful for Teaching Robotic Surgery

Telementoring Useful for Teaching Robotic Surgery

The technology facilitates teaching of advanced surgical skills, delivery of care to underserved

Lymphoceles: A Contemporary Review and an Approach for Prevention

Lymphoceles: A Contemporary Review and an Approach for Prevention

Investigators have explored various strategies to prevent lymphoceles from forming.

LDR Brachytherapy for Prostate Cancer Offers Excellent Survival

LDR Brachytherapy for Prostate Cancer Offers Excellent Survival

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In a study, the 17-year prostate cancer-specific and biochemical failure-free survival rates were 97% and 79%, respectively.

Adjuvant Better Than Early Salvage RT for Some High-risk PCa Patients

Adjuvant Better Than Early Salvage RT for Some High-risk PCa Patients

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Adjuvant radiotherapy was associated with lower risks for biochemical failure and distant metastases and increased overall survival in patients with adverse pathologic features found after radical prostatectomy.

Obesity, Metabolic Syndrome Increases Risk for PCa Recurrence

Obesity, Metabolic Syndrome Increases Risk for PCa Recurrence

Following radical prostatectomy, higher BMI increases risk of recurrence for prostate cancer.

Prostate Cancer ADT May Up Risk for Thromboembolism

Prostate Cancer ADT May Up Risk for Thromboembolism

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Androgen-deprivation therapy without estrogen is associated with a significant 43% increased risk of thromboembolic events, meta-analysis shows.

Fosfomycin Tops Fluoroquinolones for Prostate Biopsy Prophylaxis

Fosfomycin Tops Fluoroquinolones for Prostate Biopsy Prophylaxis

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In a meta-analysis, the risk of infectious complications was 78% lower with fosfomycin trometamol versus fluoroquinolones in men undergoing TRUS-guided prostate biopsy.

Prostate Cancer Gene Testing Guidelines Issued

Prostate Cancer Gene Testing Guidelines Issued

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Clinicians need to ask about cancers among members of the maternal and paternal sides of a family.

Routine Office Urine Culture Before Prostate Biopsy Is Unnecessary

Routine Office Urine Culture Before Prostate Biopsy Is Unnecessary

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In a single center study, asymptomatic bacteriuria resolved before prostate biopsy, without additional treatment.

Polygenic Hazard Score Predicts Age of Prostate Cancer Diagnosis

Polygenic Hazard Score Predicts Age of Prostate Cancer Diagnosis

Polygenic hazard score can guide screening based off predicted prostate cancer diagnosis age.

PSA at 7 Months Prognostic in Treated mHSPC

PSA at 7 Months Prognostic in Treated mHSPC

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A study showed longer survival among patients with metastatic hormone-sensitive prostate cancer who achieved a PSA level of 0.2 ng/mL or less 7 months after initiating ADT.

Mediterranean Diet Best for Lowering Aggressive Prostate Cancer Risk

Mediterranean Diet Best for Lowering Aggressive Prostate Cancer Risk

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Study finds that closely adhering to a Mediterranean-style diet possibly protects men from aggressive and advanced prostate cancer.

High-grade Prostate Cancer Risk Again Linked to Cholesterol

High-grade Prostate Cancer Risk Again Linked to Cholesterol

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Each 10 mg/dL increase in serum levels of total and HDL cholesterol are associated with a significant 5% and 14% increased risk of high-grade PCa, respectively.

Is It Safe to Avoid Biopsy in Men With Elevated PSA?

Is It Safe to Avoid Biopsy in Men With Elevated PSA?

Multiparametric magnetic resonance imaging in conjunction with transrectal ultrasound-guided biopsy improves discrimination between clinically significant and insignificant prostate tumors and can spare patients unnecessary biopsies.

Prostate Cancer Surgery Complications More Likely Among Older Men

Prostate Cancer Surgery Complications More Likely Among Older Men

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Patient age 70 years and above is an independent risk factor for perioperative morbidity, according to data from a national cohort.

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