Obesity, Metabolic Syndrome Increases Risk for PCa Recurrence
Following radical prostatectomy, higher BMI increases risk of recurrence for prostate cancer.
(HealthDay News) -- Obesity and metabolic syndrome are associated with increased recurrence among men with prostate cancer who undergo radical prostatectomy (RP), according to a study presented at the American Association for Cancer Research Special Conference -- Obesity and Cancer: Mechanisms Underlying Etiology and Outcomes -- held from Jan. 27 to 30 in Austin, Texas.
Arash Samiei, MD, from the Allegheny Health Network in Pittsburgh, and colleagues examined the correlation of body mass index (BMI) and metabolic syndrome with oncologic outcome in a retrospective study of 1100 prostatectomies, with a median follow-up of 44 months.
The researchers found that there were more obese patients in the high- versus low-/intermediate-risk group (41.2 versus 32.0%; P=0.006). In each of the risk groups there was no statistically significant difference between surgical margin status. Higher Gleason score was seen in association with metabolic syndrome (P<0.001) and a BMI >30 kg/m² (P=0.028). Significantly higher biochemical recurrence was seen for patients with BMI >30 versus <30 kg/m² (32.4 vs 16.9%; P<0.001). Compared to patients without metabolic syndrome, those with metabolic syndrome had increased risk of biochemical recurrence (odds ratio, 4.06; P<0.001).
"Our study indicates that prostate cancer patients who are obese or have metabolic syndrome undergoing RP may have a higher chance for recurrence of the disease, and these individuals should have more focused follow-up care," Samiei said in a statement.