Perioperative Aspirin Use Need Not Prevent RP

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Perioperative aspirin  use should not be considered an absolute contraindication to radical prostatectomy (RP).
Perioperative aspirin use should not be considered an absolute contraindication to radical prostatectomy (RP).

Perioperative aspirin  use should not be considered an absolute contraindication to radical prostatectomy (RP), according to investigators. 

Using the Premier Hospital Database, an all-payer hospital discharge database in the United States, Matthew D. Ingham, MD, and colleagues from Harvard Medical School in Boston studied 157,674 patients undergoing RP (4400 who continued on aspirin and 153,274 not taking aspirin). Perioperative aspirin use was not significantly associated with in-hospital complication rates. 

Although the 90-day rates of myocardial infarction, major complications, and readmission were higher among aspirin users, “we suspect this is likely the result of an uncaptured confounder—a known weakness of discharge datasets,” they concluded. Aspirin users were older, less healthy, and more likely to receive an open RP than non-aspirin users, the investigators noted.

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