Drug Name:
Promethazine HCl Tablets Rx

Generic Name and Formulations:
Promethazine HCl 12.5mg+, 25mg+, 50mg; tabs; +scored.
Company:
Various generic manufacturers
Therapeutic Use:
Indications for Promethazine HCl Tablets:
Motion sickness. Perioperative nausea & vomiting.
Adult:
Motion sickness: 25mg 30–60mins before travel; may repeat in 8–12hrs; maintenance 25mg twice daily. Perioperative nausea & vomiting: 25mg; may give additional doses of 12.5–25mg at 4–6hr intervals.
Children:
<2yrs: see Contraindications. Motion sickness: ≥2yrs: 12.5–25mg twice daily. Perioperative nausea & vomiting: 0.5mg/lb or 25mg; may give additional doses of 12.5–25mg or 0.5mg/lb at 4–6hr intervals.
Contraindications:
Children <2yrs. Dehydrated or ill children (esp. Reye's syndrome). History of sleep apnea. Asthma and lower respiratory disorders. Uncomplicated nausea in children.
Warnings/Precautions:
Glaucoma. GI or urinary obstruction. Cardiovascular or liver disease. Seizure disorders. Peptic ulcer. Bone marrow depression. Elderly. Children ≥2yrs. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions:
Potentiates CNS depression with alcohol, other CNS depressants. Caution with MAOIs. May alter hCG pregnancy test results.
See Also:
Promethazine HCl Rectal Suppositories
Pharmacological Class:
Phenothiazine.
Adverse Reactions:
Drowsiness, lowered seizure threshold, cholestatic jaundice, anticholinergic and extrapyramidal effects, photosensitivity, hypo- or hypertension, rash, blood dyscrasias, nausea, neonatal platelet abnormalities; children: respiratory depression (may be fatal).
Note:
Formerly known under the brand names Phenergan (tabs, supps); Promethacon (supps).
How Supplied:
Contact supplier.
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