Overactive Bladder

Nocturia More Bothersome Than Daytime LUTS

Nocturia More Bothersome Than Daytime LUTS

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Clinicians tend to focus on the number of voids, but patients worry more about interrupted sleep.

Hypoxia Not Linked With Nocturia

Hypoxia Not Linked With Nocturia

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Rather intermittent oxygen desaturation was associated with a 3% greater likelihood of nocturia.

FDA Approves Mirabegron Solifenacin Combo for OAB

FDA Approves Mirabegron Solifenacin Combo for OAB

In clinical trials, the combination of Myrbetriq + solifenacin succinate was associated with greater improvements in the number of incontinence episodes per 24 hours (primary endpoint), the number of micturations per 24 hours (primary endpoint), and the volume voided per micturation (secondary endpoint) compared to placebo or to individual active components.

Predictors of Pediatric OAB Healing Time Identified

Predictors of Pediatric OAB Healing Time Identified

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Thicker bladder wall and a tower-shaped curve on uroflowmetry are associated with shorter healing periods among pediatric patients with overactive bladder.

Nasal Spray for Nocturia Is Safe, Effective

Nasal Spray for Nocturia Is Safe, Effective

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More patients taking desmopressin decreased their nightly voiding episodes by half or more.

Urodynamics Influence OAB Treatment Decisions

Urodynamics Influence OAB Treatment Decisions

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Clinicians' choice of treatment highly correlated with a diagnosis based on urodynamic studies.

Nonpharmacologic Therapy Ups Sleep Quality in Women With Nocturia

Nonpharmacologic Therapy Ups Sleep Quality in Women With Nocturia

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At least half of women using tibial nerve stimulation or pelvic floor muscle training experienced fewer night awakenings, according to a new study.

Nocturia in Men Linked to Metabolic Syndrome, Smoking

Nocturia in Men Linked to Metabolic Syndrome, Smoking

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Metabolic syndrome and smoking are associated with 2.5- and 1.7-fold increased odds of moderate or severe nocturia in men with BPH/LUTS.

 Sleep Disorders in Men Associated With Nocturia

Sleep Disorders in Men Associated With Nocturia

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In a study, men with sleep disorders were 23% and 27% more likely to report nocturia and daytime LUTS than men without sleep disorders.

Poor Sleep Quality Common in Women With Urgency Incontinence

Poor Sleep Quality Common in Women With Urgency Incontinence

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At baseline, women reported an average of 3.9 urgency incontinence episodes per day and 1.3 episodes of nocturia per night.

Nocturia May Contribute to Sleep Problems in ADT Recipients

Nocturia May Contribute to Sleep Problems in ADT Recipients

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In a 12-month study, men with prostate cancer treated with ADT reported more nocturia episodes than men with prostate cancer treated with prostatectomy alone and men with no history of cancer.

Methylene Blue Improves Onabotulinum Toxin A Injection Technique

Methylene Blue Improves Onabotulinum Toxin A Injection Technique

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Methylene blue aids observation of the procedure and assessment of drug distribution.

Antimuscarinic Therapy for OAB Linked to Depression in Women

Antimuscarinic Therapy for OAB Linked to Depression in Women

Clinicians should be alert to the relationship between antimuscarinics usage and depressive disorder in OAB women and provide appropriate instructions for these patients.

Botulinum Toxin Evaluated for Overactive Bladder

Botulinum Toxin Evaluated for Overactive Bladder

Onabotulinumtoxin A successfully reduced urinary frequency and urgency, but not urgency urinary incontinence episodes.

Oxybutynin Overprescribed for Overactive Bladder in Elderly

Oxybutynin Overprescribed for Overactive Bladder in Elderly

Pharmacologic properties of oxybutynin may cause significant cognitive side effects in elderly persons.

OAB Drug Mirabegron Shows Superior Patient Adherence

OAB Drug Mirabegron Shows Superior Patient Adherence

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Treatment discontinuation rate is lower than that of traditional antimuscarinics, study finds.

Long-Term BoNT-A Therapy Compliance Low Among Men

Long-Term BoNT-A Therapy Compliance Low Among Men

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Only a quarter of men receiving injections of BoNT-A comply with the treatment long-term.

OAB Sacral Neuromodulation Causes Few Serious Adverse Events

OAB Sacral Neuromodulation Causes Few Serious Adverse Events

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Prospective study reveals a 1-year surgical intervention rate of 13%.

OnabotulinumtoxinA Provides Lasting Benefit in Overactive Bladder

OnabotulinumtoxinA Provides Lasting Benefit in Overactive Bladder

Consistent mean reductions in urinary incontinence; durable improvements in quality of life.

Surgical Revision Rate 4% for Mesh-Based Prolapse Surgery

Surgical Revision Rate 4% for Mesh-Based Prolapse Surgery

Reoperation rate for transvaginal mesh prolapse surgery is 4%.

Post-RP Radiation Therapy May Raise OAB Risk

Post-RP Radiation Therapy May Raise OAB Risk

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De novo OAB — defined as urgency with or without frequency and nocturia — developed in some patients.

Patients on Psychiatric Meds Report More Severe OAB Symptoms

Patients on Psychiatric Meds Report More Severe OAB Symptoms

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These same patients, however, had less intense detrusor overactivity, urodynamic evaluation revealed.

Specialists More Likely to Prescribe Newer OAB Drugs Initially

Specialists More Likely to Prescribe Newer OAB Drugs Initially

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Urologists and gynecologists are 49% and 30% more likely than primary care doctors to prescribe second-generation agents.

Potential Medication Misuse Common With OAB

Potential Medication Misuse Common With OAB

Potentially inappropriate medication use is prevalent in older adults undergoing antimuscarinic treatment for overactive bladder.

Mirabegron Found to Relieve Refractory OAB in Children

Mirabegron Found to Relieve Refractory OAB in Children

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Patients' median bladder capacity improved from 150 to 200 mL and continence improved in nearly 90% of patients.

Overactive Bladder Risk Higher in Women Who Smoke

Overactive Bladder Risk Higher in Women Who Smoke

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Researchers also find a significant association between smoking and secondary nocturnal enuresis.

Botox Effectively Treats New OAB After Incontinence Surgery

Botox Effectively Treats New OAB After Incontinence Surgery

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A high cure rate was observed in women with de novo OAB symptoms following transobturator tape surgery.

Combo Superior for Overactive Bladder in BPH Patients

Combo Superior for Overactive Bladder in BPH Patients

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Symptom improvement was greater in patients receiving tamsulosin plus darifenacin compared with tamsulosin monotherapy.

Pelvic Floor Stimulation Improves OAB in Perimenopausal Women

Pelvic Floor Stimulation Improves OAB in Perimenopausal Women

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Adding vaginal estrogen may sustain the effects.

Two-Drug Combo Effective for Severe OAB in Elderly

Two-Drug Combo Effective for Severe OAB in Elderly

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Among seniors with severe overactive bladder, a combination of solifenacin and mirabegron decreased incontinence by an average 3.5 episodes a day.

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