Mortality Risk After Community-Acquired AKI Lower in Women

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Investigators report that female vs male sex was associated with a significant 14% lower mortality risk following an episode of community-acquired acute kidney injury.
Investigators report that female vs male sex was associated with a significant 14% lower mortality risk following an episode of community-acquired acute kidney injury.
The following article is part of conference coverage from the NKF 2018 Spring Clinical Meetings in Austin hosted by the National Kidney Foundation. Renal & Urology News staff will be reporting on medical studies conducted by nephrologists and other specialists who are tops in their field in chronic kidney disease, dialysis, transplantation, and more. Check back for the latest news from NKF 2018.

AUSTIN, Texas—Female sex is associated with lower mortality risk following an episode of community-acquired acute kidney injury (CAAKI), researchers reported at the National Kidney Foundation's 2018 Spring Clinical Meetings. The protective effect of female sex was more pronounced among individuals with more severe CAAKI.

In a study of 67,990 individuals hospitalized from January 2009 to November 2011, Robert Adrah, MD, and colleagues at Albert Einstein College of Medicine/Montefiore Medical Center in Bronx, New York, found that female patients with any CAAKI had a significant 14% lower risk of death compared with male patients. The investigators also examined mortality risk according to different Acute Kidney Injury Network (AKIN) criteria. Among individuals meeting AKIN 1, 2, and 3 criteria, female patients had a 16%, 19%, and 19% lower mortality risk, respectively, compared with male patients. Female patients had less severe disease and lower Charlson comorbidity scores, which explains some, but not all, of the protective effect, according to the investigators.

Dr Adrah's team, which included senior author Ladan Golestaneh, MD, MS, and Joel Neugarten, MD, defined CAAKI using the creatinine portion of AKIN criteria.

On multivariable analysis, increasing age, male sex, higher Charlson comorbidity score, and length of index hospitalization stay were associated with increased mortality risk.

See more coverage from the National Kidney Foundation Spring Clinical meeting

Reference

Adrah R, Neugarten J, Golestaneh L. Female sex protects against mortality after an episode of community acquired acute kidney injury (AKI). Data presented at the National Kidney Foundation's 2018 Spring Clinical Meetings in Austin, Texas, April 10–14. Poster 1.

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