ADPKD-Related Kidney Failure Occurs Earlier in Non-Hispanic Blacks

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Among patients younger than 40, the prevalence of ESRD secondary to ADPKD was 9.94% among non-Hispanic blacks vs 7.68% among non-Hispanic whites.
Among patients younger than 40, the prevalence of ESRD secondary to ADPKD was 9.94% among non-Hispanic blacks vs 7.68% among non-Hispanic whites.
The following article is part of conference coverage from the NKF 2018 Spring Clinical Meetings in Austin hosted by the National Kidney Foundation. Renal & Urology News staff will be reporting on medical studies conducted by nephrologists and other specialists who are tops in their field in chronic kidney disease, dialysis, transplantation, and more. Check back for the latest news from NKF 2018.

AUSTIN, Texas—Non-Hispanic blacks have a lower incidence of autosomal dominant polycystic kidney disease (ADPKD) than non-Hispanic whites, but those with the disease progress to end-stage renal disease (ESRD) at an earlier age, investigators reported at the National Kidney Foundation's 2018 Spring Clinical Meetings.

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Erin L. Murphy, MHS, of the Yale School of Medicine in New Haven, Connecticut, and colleagues arrived at these findings in a study comparing ADPKD incidence and outcomes in non-Hispanic blacks (NHBs) and non-Hispanic whites (NHWs). Results showed that non-Hispanic blacks were 62% less likely than non-Hispanic whites to have ADPKD, but among patients younger than 40 years, the proportion of individuals with ESRD secondary to ADPKD was significantly higher among NHBs than NHWs (9.94% vs 7.68%). Among patients older than 50 years, however, ESRD secondary to ADPKD was more common among NHWs than NHBs. The investigators observed no significant difference in the prevalence of ADPKD-related ESRD among patients aged 40 to 44 years and 45 to 49 years.

NHBs with ADPKD had a significantly lower mean age at ESRD onset than NHWs (54.4 vs 55.9 years).

The researchers used the US Renal Data System database to identified NHBs and NHWs classified as having ESRD secondary to ADPKD, hypertension/large vessel disease, or diabetes mellitus for the years 2004 to 2013.

“The overall incidence of ESKD due to ADPKD is lower in non-Hispanic blacks compared to non-Hispanic whites, however, NHBs progress to ESKD at an earlier age,” Murphy told Renal & Urology News. “Therefore, in ADPKD, black race may be an additional risk factor for progression to ESKD.  In this way ADPKD may be similar to other kidney diseases in which NHBs are over-represented.”

See more coverage from the National Kidney Foundation Spring Clinical meeting

Reference

Murphy EL, Dai F, Blount KL, et al. ESKD from ADPKD in the US: Incidence is lower but age of onset is earlier in non-Hispanic blacks compared to non-Hispanic whites. Data presented at the National Kidney Foundation's 2018 Spring Clinical Meetings held in Austin, Texas, from April 10-12. Poster 293.

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