Nephrology News Archive
Two studies show increased risk for cardiovascular disease in association with hypertension.
For men with nocturnal polyuria, the rate of urine production dropped off as the night progressed.
In a study, older men with difficulty walking or climbing stairs reported better physical function after testosterone therapy.
Poor clinical outcomes linked to extended spectrum cephalosporin-resistant Enterobacteriaceae.
Avelumab plus axitinib is associated with longer progression-free survival compared with sunitinib as first-line therapy in patients with advanced renal cell carcinoma.
Findings among patients with end-stage renal disease initiating dialysis.
In an observational UK study, chronic kidney disease stage 3 or higher was 78% more likely to develop in patients with vs without gout during a median follow-up of 6 years.
Treatment with bardoxolone methyl resulted in significant weight loss and showed no evidence of muscle wasting in patients with type 2 diabetes and stage IV chronic kidney disease.
Higher risk for premature birth, low birth weight, low Apgar score seen with older paternal age.
Intervention plus motivational interviewing better than health education alone for black adults.
Investigators conclude that microarray-generated cell cycle progression score should not be assumed to be a valid surrogate for qRT-PCR-generated scores.
Patients undergoing hemodialysis typically receive intravenous iron, despite a lack of established clinical efficacy. In this randomized controlled trial, investigators randomized 2141 patients undergoing hemodialysis to either high-dose iron sucrose, administrated proactively, or low-dose iron-sucrose, administered reactively to compare the safety and efficacy of these regimens in patients undergoing hemodialysis. The primary outcome examined was 
Single-dose disposable auto injector approved for once-weekly subcutaneous administration of testosterone may cut down on potential problems associated with other options.
Promising results from clinical trials could encourage urologists to offer immunotherapy to their bladder cancer patients.
In a Canadian study of patients who experienced AKI during hospitalization, treatment with an ACEI or ARB within 6 months of discharge was associated with a 15% lower risk for death after 2 years.
As stearic acid and total fatty acid intake increased from one quintile to the next, prostate risk increased by 23% and 21%, respectively.
In a recent meta-analysis, testosterone therapy was not associated with major or minor adverse cardiovascular events.
Patients with Medicare, Medicaid more likely to use arteriovenous fistula, graft by fourth dialysis month.
Strict BP control, fenofibrate use may increase long-term risk for adverse kidney events in T2DM patients
Two US cohorts support use of home BP threshold of 130/80 mm Hg for black, white, Hispanic adults
Delivering care at a distance may enable practices to expand their current geographic boundaries and enhance patient satisfaction.
Active involvement in the digital ecosphere is vital to patient engagement.
A multiplex polymerase chain reaction assay detected bacteria species missed by traditional urine culture as well as more fastidious bacteria.
Chicago urologist Richard Harris, MD, says one of the biggest challenges facing independent urology practices is the constantly changing Medicare rules and regulations.
Patient selection and physician-patient commitment to careful follow-up surveillance are key.
In a study, reduced mortality was found among TRT users with type 2 diabetes after adjustment for cardiovascular risk factors.
Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use linked with decreased mortality after inpatient acute kidney injury.
1. In this retrospective cohort study looking at patients admitted to hospital with acute kidney injury, use of angiotensin-converting enzyme inhibitor or angiotensin receptor blocker within six months was associated with decreased mortality. 2. Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use was also associated with increased risk of hospitalization for a renal cause (hyperkalemia, 
Findings from a large contemporary cohort of men on active surveillance for prostate cancer shows that disease characteristics, not socioeconomic factors, are driving prostate cancer management.
Mistrust, lack of knowledge, unfavorable attitudes are barriers to genomic testing, study participation
Whites with heart failure more likely to be hospitalized for higher-clinical-acuity visits.
To investigate the risk of cardiovascular adverse effects associated with this antibiotic class, researchers conducted a systematic review, meta-analysis, and network meta-analysis using studies identified through a search of MEDLINE, EMBASE, and the Cochrane Library.
Each one-standard deviation increase in air temperature tied to 2.8% reduction in MI risk
UGN-1 is an investigational formulation of mitomycin, delivered to patients using standard intravesical catheters.
The effect of Invokana on CV risk was evaluated in the CANVAS (CANagliflozin cardioVascular Assessment Study) Program in >10,000 adults with T2D who had established CV disease or were at risk for CV disease with ≥2 risk factors.
Local control, cancer-specific survival at 2 years similar for patients with solitary, bilateral kidneys
New multidisciplinary guideline for early-stage prostate cancer developed by 3 professional societies.
Higher risk seen with ACEIs vs angiotensin receptor blockers; risk linked to duration of use
HHS study shows Medicare pays 80% more than other countries for certain prescription drugs.
Also do not correlate well with reperfusion biopsies, not linked to transplant outcomes
Results from phase 2 study in patients with multidrug-resistant Gram-negative uropathogens.
At the time of diagnosis of renal cell carcinoma, blacks had 33% lower odds of regional disease compared with whites, a new study found.
The 3-year survival rate was 81% for patients who underwent EBRT plus standard care vs 73% for those who had standard care alone.
Allopurinol use is not associated with renal function decline among those with newly diagnosed gout.
Trials show high survival rates, freedom from recurrence for low-, intermediate-risk prostate cancer.
Significant reduction seen in hospitalization with receipt of high-dose versus standard-dose vaccine.
Donor profile index of transplanted kidneys has risen modestly in US, with greater increase in France.
The professional obligation to promote the health and wellbeing of the members of society is central to the legitimacy and integrity of the profession.
The LUGPA 2018 Annual Meeting will take place from November 1-3, 2018, in Chicago, Illinois.
1. Patients managed with intensive blood pressure reduction were found to have significantly greater decreases in kidney damage biomarkers compared to standard blood pressure management. 2. Higher levels of kidney damage biomarkers at baseline were associated with greater odds of developing chronic kidney disease. Evidence Rating Level: 2 (Good) Study Rundown: Systolic blood pressure (SBP) 
Regardless of the type of audit a practice is performing, the starting point for most of them is internal.
Markers of bone resorption decreased in hemodialysis patients with 6 months of etelcalcetide treatment.
Analyses demonstrated that an ABI of 1.79 correlated with radiographic evidence of calcified vessels.
Epoetin dose is significantly associated with cardiovascular disease whether patients had lower or higher hemoglobin levels, study finds.
In a study, IV iron was associated with twice the risk for infections in CKD.
In a study, patients receiving cinacalcet under supervision 3 times per week after dialysis rather than after daily self-administration showed improvement in their parathyroid hormone levels.
In a study, patients with uncontrolled SHPT were switched from oral cinacalcet to intravenous etelcalcetide.
Loss of renal function may not be the sole factor in SHPT development, according to new study findings.
A study of new dialysis patients showed that home hemodialysis was associated with a 23% decreased risk of death at 1 year compared with in-center hemodialysis.
A polymer that binds to hydrochloric acid in the GI tract and does not enter the systemic circulation significantly improved serum bicarbonate levels compared with placebo.
In a study of 933 individuals with a mean age of 78 years, higher serum uromodulin was associated with a lower risk of end-stage renal disease.
In a propensity score-matched analysis, AKI was associated with a 3.4-fold greater risk of dementia.
Study reveals an 11% prevalence of active gout among solid organ transplant recipients overall and a 13% prevalence among kidney transplant recipients.
Highest vs lowest quartile of intact fibroblast growth factor 23 is associated with a 2-fold greater risk of a first fall in older patients.
Randomized controlled trial finds no significant difference between high- and low-dose intravenous iron with respect to mortality, non-fatal cardiovascular outcomes, and infection.
Taiwan study reveals a 38% increased risk of ischemic stroke among patients with nephrotic syndrome.
Patients with chronic kidney disease who have hyperuricemia have a 3-fold higher risk of all-cause mortality.
Statin use vs non-use among patients hospitalized with dialysis-requiring acute kidney injury is associated with decreased risks of 1-year and in-hospital all-cause mortality, a study found.
Use of muscle relaxants was associated with a 68%, 29%, and 30% increased risk of altered mental status, falls, and fractures, respectively.
Marijuana users with chronic kidney disease experienced a significantly greater annual decline in estimated glomerular filtration rate than non-users, study finds.
In a study, patiromer lowered serum phosphate in patients with hyperkalemia and hyperphosphatemia.
Higher percentages of women than men on hemodialysis have anemia, infections, hypertension, and diabetes, study finds.
In a study, kidney transplant recipients with a BMI (in kg/m2) higher than 35 have graft and patient outcomes similar to those with a BMI of 30 to 35.
In a study, 42.4% of patients with serum phosphorus of 5.6 to 7 mg/dL lowered their levels to less than 5.5 mg/dL over 2 years.
In a study, patients received half the amount of iron during the reduced dosing period: 126.6 vs 51.2 mg/month.
3 percent of midurethral mesh slings for stress urinary incontinence removed by 9 years
Individuals with a serum bicarbonate level below 24 mEq/L have a 2-fold increased risk of AKI compared with those with a level of 25-28 mEq/L.
Canagliflozin vs placebo is associated with increased survival and renal outcomes in patients with type 2 diabetes and macroalbuminuria.
Patients who lose 10% or more of their body weight from the time of their listing on a transplant waiting list are at higher risk of death following deceased-donor kidney transplantation.
Higher levels of urinary oxalate excretion in patients with chronic kidney disease are associated with an increased risk of end-stage renal disease and chronic kidney disease progression.
In a study, progression of calcification did not increase until eGFR falls below 40 mL/min/1.73 m2.
Peritoneal dialysis patients with MCV of 96 fl or more had a 29% greater risk for early death compared with a reference group.
Serum magnesium levels of 2.6 mg/dL or higher at 1 year predict a 52% decreased risk of death from any cause.
Patients who received hemodialysis 6 times per week instead of 3 showed improvements in biomarkers of mineral metabolism and left ventricular remodeling.
Higher magnesium levels are associated with a lower risk of peripheral artery disease, but only among individuals without impaired renal function.
Study finds that black adults in the Southeastern United States who report higher religiosity are at lower risk of end-stage kidney disease.
In the first year after starting dialysis, women have 16% increased odds of major adverse cardiovascular events compared with men.
The objective is to stimulate innovation by industry, academic institutions, and other organizations.
Incident CKD accompanied by decreases in kidney damage biomarkers in setting of intensive treatment.
Spanish study found no significant difference between febuxostat and allopurinol with respect to risk of new cardiovascular events among gout patients without prior cardiovascular disease.
In asymptomatic patients, AUC was higher for AAC than for Framingham Risk Score at all time points.
Fasting plasma glucose, BMI elevated 10 years before diagnosis of prediabetes, diabetes.
Risk of hospitalization up for Hispanic patients with lower scores on Ambulatory Care Experiences Survey
Radiation dose not impacted with light or moderate use of skin treatments, regardless of beam energy, incidence
In a British study, nurse-led care emphasizing patient education and engagement significantly improved the proportion of gout sufferers who achieved target serum urate levels.
Long-term data show a local disease recurrence rate of 2.1% at 10 years.
Long-term oncologic outcomes of patients with sporadic RCC who underwent robotic tumor enucleation suggest the procedure is safe.
In a study, arteriovenous fistula blood flow, diameter, and depth were the most informative parameters.
Double-dose influenza vaccine is safe and may increase antibody response in solid-organ transplant recipients
Canada is first major world economy to legalize recreational marijuana use
Well-being and medication adherence negatively linked to psychological morbidity, dialysis.
Renal and Urology News Articles
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NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)