Nephrology News Archive
Restoration of iron homeostasis and normal hepcidin levels appears to play a key role in freeing hemodialysis patients from having to receive erythropoiesis-stimulating agents.
Enhanced cystoscopy at the time of cystectomy and in the outpatient surveillance setting increases detection of high-grade NMIBC.
Australian study shows 8-year overall survival and biochemical relapse-free rates of 78.4% and 68.1%, respectively.
Time-averaged hemoglobin levels, not hemoglobin cycling, is associated with an increased risk of left ventricular hypertrophy in pediatric dialysis patients, a study found.
Japanese post-marketing study identified no new safety concerns among patients with non-dialysis chronic kidney disease treated with darbepoetin alfa and followed up for 3 years.
In a Spanish study, endoscopic evaluation of patients with CKD and anemia revealed that 68.2% of patients had at least 1 gastrointestinal lesion.
The 10-year prevalence of colonoscopy-documented colorectal cancer was 0.8% among gout patients vs 3.7% among osteoarthritis patients.
Men who received androgen deprivation therapy for prostate cancer were 54% more likely to be diagnosed with non-alcoholic fatty liver disease than those who did not, a study found.
A novel oral formulation of urea increased plasma sodium levels significantly and was well tolerated, according to investigators.
Finnish study of individuals with type 2 diabetes reveals a 17% and 42% higher incidence of bladder and kidney cancer, respectively, compared with the general population.
New study reveals a type 2 diabetes incidence rate of 17.81 cases per 1000 person-years, a rate much higher than in the general population.
Study of patients with CKD stage 3 and asymptomatic hyperuricemia showed that febuoxostat ameliorated the annual decline in eGFR vs placebo in those without proteinuria.
Salt intake below 6 g/day is associated with increased odds of all-cause and cardiovascular in patients on hemodialysis, Japanese study shows.
In a large Swedish study of middle-aged individuals, increments in baseline serum urate levels were associated with progressively increased risks of gout over a mean 28 years of follow-up.
Higher rates of complete response observed in MIBC patients who received a dose-dense combination of methotrexate, vinblastine, doxorubicin, and cisplatin rather than the standard gemcitabine plus cisplatin or carboplatin.
In a German study of patients starting first-line systemic therapy for advanced renal cell carcinoma, patients with a low BMI were twice as likely to die as those with a high BMI.
Recurrent kidney stone formers are at higher risk of end-stage renal disease than patients who form incident symptomatic stones, study finds.
The risk being lost to follow-up while on active surveillance for prostate cancer is higher among blacks than whites, according to a study.
Low serum sodium chloride concentrations are associated with an increased risk of renal function decline events, especially among patients with CKD stage G4 and anemic patients.
Desmopressin orally disintegrating tablets resulted in declines in nocturnal voids in men and women with nocturnal polyuria and mild daytime voiding dysfunction.
Hearing impairment is 44% more likely to develop in Medicare patients with vs without gout, a study of Medicare claims data shows.
In a study, 28% of all incident in-hospital falls were associated with nighttime visits to the toilet.
Elevated levels of serum ferritin, which stores excess iron, are positively associated with gout risk, investigators concluded.
In a study, nocturnal polyuria was present in 30% of women with overactive bladder.
For valid informed consent to exist, patients have to understand the information physicians give them about a proposed treatment or procedure.
LUTS treatment with the alpha-blocker prazosin was associated with significantly lower 2- and 5-year biochemical recurrence rates vs tamsulosin and non-use of alpha-blockers.
Taking 2 or more drugs for hypertension is associated with a significantly higher number of nocturnal voids and higher nocturnal polyuria index, study finds.
Novel imaging and tumor biomarker assays are likely to define non-metastatic castration-resistant prostate cancer more accurately, authors of new review state.
Phase 4 trial showed that mirabegron significantly decreased incontinence episodes and micturitions compared with placebo among patients aged 65 years and older.
A study of commercially insured patients showed Asians and Hispanics were less likely than whites to undergo advanced overactive bladder treatments.
Study suggests male OAB could be associated with abnormalities in metabolic pathways of fatty acids and bile acids.
Even modestly elevated fasting plasma glucose levels and HbA1c is associated with increased odds of overactive bladder.
The ratio of visceral fat volume to total abdominal fat volume is an independent risk factor for overactive bladder, study finds.
German study revealed a 13% higher risk of falls among patients with vs without nocturia.
Of patients who had transient stress urinary incontinence after holmium laser enucleation of the prostate, 88.6% experienced resolution of the incontinence within 6 weeks after the procedure.
An expert panel developed a framework of 22 nocturia phenotypes that could set the stage for devising diagnostic and treatment pathways and stimulating research.
Canadian study documents a fall in the annual rate of transvaginal sling procedures for female stress incontinence after 2009.
Among patients with detrusor underactivity, 14% of women had neuropathic causes compared with only 2% of men.
Nearly 55% of men with lower urinary tract symptoms suffer from nocturnal polyuria, according to a study conducted in Italy.
Mirabegron use for overactive bladder rose to 16% in 2016, whereas anticholinergic use decreased to 78% in 2016 from 97% in 2003, a study found.
In a phase 2 trial, treatment with an acetaminophen-ibuprofen combination was associated with a significant reduction in nocturnal voids and improved quality of life compared with placebo.
Use of ultra-low contrast volume during percutaneous coronary intervention was associated with 32% decreased odds of acute kidney injury, investigators report.
Lower urinary tract symptom severity in men is associated with detectable bacteria in urine obtained via catheter, new study suggests.
Low-dose-rate brachytherapy is associated with excellent long-term biochemical control and survival, new study finds.
Even low cumulative exposure to physical strain at work is associated with a decreased risk of prostate cancer, study finds.
Factors to consider before allowing patients online access to their medical information.
Concerns about nutritional deficiency in CKD patients are unfounded, and plant-based diets may actually be good for them, the authors of a new report contend.
In a study, men with low-risk prostate cancer were nearly 2-fold more likely to be managed with observation if they had a prostate MRI during the diagnostic work-up.
Prospective study at Johns Hopkins shows excellent oncologic outcomes and preserved mental quality of life for all patients regardless of management strategy, with worse renal function after radical nephrectomy.
Urinary stone formation in adults increases the odds of asthma by 26%, according to a study.
Nonsurgical treatment of small tumor renal cancer may be as effective as radical nephrectomy but with fewer complications
1. Rates of renal insufficiency were highest in patients receiving renal nephrectomy, compared to less invasive treatments. 2. Survival rates for renal nephrectomy and partial nephrectomy were very similar, suggesting little difference in efficacy between these treatments. Evidence Rating Level: 2 (Good) Study Rundown: Renal stage carcinoma (RCC) has relatively low mortality rates with respect 
Elderly patients who start dialysis with a central venous catheter but convert to an arteriovenous fistula within the first year lower their death risk significantly.
A "weekday-on and weekend-off regimen" improves relative dose intensity compared with the conventional regimen, a study found.
A new study found that 24-hour urine phosphorus is inversely related to whole-body retention, but is not related to net intestinal absorption.
In a controlled study, a high-phosphate diet increased systolic and diastolic blood pressure and pulse rate in people with normal renal function.
New meta-analysis shows adjuvant intravesical gemcitabine and bacillus Calmette-Guérin do not differ significantly with respect to risk of recurrence, progression, and adverse events.
Potential donors undergoing multidetector computed tomography during their assessment should be counseled on the medical implications of incidentally discovered lesions.
Highest vs lowest quartile of serum phosphorus is independently associated with a nearly 3-fold increased risk of diabetic nephropathy progression.
Men prescribed 3 different phosphodiesterase type 5 inhibitors had nearly 3-fold increased odds of having a Charlson Comorbidity Index of 1 or higher than men not prescribed the drugs.
At a major tertiary referral center, the use of radical prostatectomy for insignificant prostate cancer decreased from 15% in 2009 to 3% in 2016, a study found.
In a study, 8 mg of silodosin daily for 12 weeks was associated with a significant reduction in nocturia episodes.
A recent paper provides 8 questions to ask patients to elicit information that enables targeted treatment of nocturia.
1. Within a cohort of infants born extremely preterm (EPT), there were elevated rates of high systolic blood pressure (SBP≥90%ile) and hypertension (SBP≥95%ile) when these children reached school age. 2. School age children with high SBP who were born EPT, were significantly more likely to have been born to mothers with gestational diabetes, and as 
A patient's risk of suicide is doubled within the first year following a prostate cancer diagnosis, according to a new meta-analysis.
Study of Korean radical prostatectomy patients showed that those who were obese had significant increased odds of biochemical recurrence and cancer-specific mortality
Proportion achieving target BP increased with use of triple combo pill versus usual care at six months.
Among US dialysis patients, cardiovascular event rates are highest in those with diabetic nephropathy and lowest among those with IgA nephropathy.
Patients on hemodialysis who achieved serum phosphate levels below 4.5 mg/dL experienced a decrease in intact fibroblast growth factor 23.
In a study, hemodialysis patients who used phosphate binders had up to a 44% decreased risk of dying from infection than those who did not use the drugs.
Small study found that 2 mg of melatonin taken at bedtime did not significantly decrease the mean number of nocturia episodes vs placebo.
Using HCV-infected kidneys greatly reduces wait time for transplantation and improves survival for patients with HCV
1. Use of HCV-infected kidneys increased patients' quality-adjusted life expectancy. 2. Lower costs were associated with HCV-infected kidneys compared to transplanting HCV-uninfected kidneys to HCV-positive patients. Evidence Rating Level: 2 (Good) Study Rundown: Organ availability for transplantation is limited; therefore, for patients with end stage renal disease (ESRD), hemodialysis is often the final treatment compared 
Clinicians should assess whether women experience urinary incontinence and whether it affects their health, function, and quality of life.
New study suggests sodium intake is associated with cardiovascular disease and stroke only when mean sodium intake exceeds 5 grams per day.
Cytoreductive radical prostatectomy (RP) for metastatic prostate cancer (PCa) is associated with higher complication rates and longer hospital stays than RP for non-metastatic PCa.
In a study, percutaneous coronary intervention was associated with a 72% decreased risk of acute renal failure compared with coronary artery bypass grafting in patients with chronic kidney disease.
Contraindicated pregnancy medications
Chart with medications used to treat neuropathic pain, including diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia.
Treatment options for obesity including strength, form, and dosing details.
Antidiabetic agents for the treatment of diabetes including maintenance and max doses chart.
Data show that gout is associated with an increased risk of developing erectile dysfunction.
AMA House of Delegates has adopted policy to study, act for, advocate gender equity in medicine.
A systematic process is necessary to prove an incident involving medical records did not result in a breach.
Identification of DNA repair defects within prostate cancer tissue may enable a precision oncologic approach to treatment.
From 2000 to 2015 screening for breast, cervical, and prostate cancers decreased significantly, whereas screening for colorectal cancer increased significantly.
Patient data hacking is a risk even for small practices.
Physicians increasingly are prescribing high dose and very high dose radiation therapy after radical prostatectomy despite an absence of randomized trials supporting the practice.
Study suggests the optimal range is 3.36 to 5.18 mmol/L in CKD stage 3 and 3.26 to 5.53 mmol/L in CKD stages 4 to 5.
Patients may benefit from earlier lines of enzalutamide for the treatment of metastatic castration-resistant prostate cancer.
Docs will have more opportunity to use technology with extra codes approved by CPT Editorial Panel.
Secondary hyperparathyroidism in postmenopausal women with vitamin D insufficiency is associated with lower weight-adjusted bone mineral density in the lumbar spine.
In a study, the off-clamp approach to partial nephrectomy also was associated with lower risk for acute kidney injury.
In a small study, total parathyroidectomy without autotransplantation improved bone mineral density in the lumbar spine and hip in ESRD patients with secondary hyperparathyroidism.
Zemdri carries a Boxed Warning describing reports of nephrotoxicity, ototoxicity, and neuromuscular blockade, as well as fetal harm if administered during pregnancy.
Measurement of plasma copeptin better than water-deprivation test in patients with hypotonic polyuria.
Stage 1 acute kidney injury accounted for the biggest growth in incidence rate.
Researchers examined the effects of the end of public funding for the medication in Australia.
Obese or overweight individuals have significantly lower levels of 25-hydroxyvitamin D than normal-weight individuals at any level of kidney function, a study found.
Circulating blood biomarkers related to angiogenesis may help clinicians predict who will have a robust response to sunitinib.
All 20 recipients experienced HCV cure, good quality of life, excellent renal function.
Renal and Urology News Articles
Sign Up for Free e-newsletters
NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)