Hyponatremia Increases Risk of Fracture
Phosphorus, Calcium Decreases Linked to Improved HD Patient Survival
AUSTIN, Texas—Hyponatremia is strongly associated with an increased risk of fracture and osteoporosis, according to the findings of a new systematic review and meta-analysis presented at the National Kidney Foundation's 2018 Spring Clinical Meetings.
The meta-analysis, which included 25 studies, found that hyponatremia, defined as a serum sodium level below 135 mmol/L, was associated with 2.7- and 2.5-fold greater odds of fracture in prospective and retrospective studies, respectively, and 2.7-fold increased odds of osteoporosis, Kalyani Murthy, MD, MS of Lahey Hospital & Medical Center in Burlington, Massachusetts, and colleagues reported in a poster presentation. Patients had a mean age of 73 years. The proportion of female patients ranged from 60% to 90%. Eleven studies evaluated all fractures and 4 evaluated hip fractures.