Endurance Exercise Tied to Anti-Aging at Cellular Level
Effect seen with aerobic endurance and high-intensity training but not resistance training
(HealthDay News) -- Endurance exercise has anti-aging effects visible at the cellular level, according to a study published online in the European Heart Journal.
Christian M. Werner, MD, from Saarland University in Saarbrücken, Germany, and colleagues randomly assigned 124 healthy, previously inactive individuals to a control condition (no change in lifestyle), aerobic endurance training (AET; continuous running), high-intensive interval training (IT; 4x4 method), or resistance training (RT; circle training on 8 devices). Each intervention included three 45-minute training sessions per week. Measurements examined the cellular effects of the different training modalities.
The researchers found that maximum oxygen uptake (VO2max) increased with all three training modalities. In both endurance exercise groups (AET, IT), telomerase activity in blood mononuclear cells was upregulated twofold to threefold, but this effect was not seen with RT. Further, lymphocyte, granulocyte, and leucocyte telomere length (TL) increased in the endurance-trained groups but not in the RT group. A single bout of endurance training, but not RT, acutely increased telomerase activity in CD14+ and in CD34+ leucocytes, as detected with magnet-activated cell sorting with telomerase repeat-amplification protocol assays.
"Endurance training and IT, but not RT, increased telomerase activity and TL which are important for cellular senescence, regenerative capacity, and thus, healthy aging," the authors write.
Werner CM, Hecksteden A, Morsch A, et al. Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled study. Eur Heart J
Stellos K and Spyridopoulos I. Exercise, telomerase activity, and cardiovascular disease prevention. Eur Heart J DOI:10.1093/eurheartj/ehy707