Opioid Equianalgesic Doses
|OPIOID EQUIANALGESIC DOSES|
All equivalencies should be considered approxi-
|Generic||Dose Equal to 10mg IM
of Morphine Sulfate
Key: CR=controlled-release; IR=immediate-release
1Although controlled studies are not available, in clinical practice it is customary to consider the doses of opioids given IM, IV, or SC to be equivalent. There may be some differences in pharmacokinetic parameters such as Cmax and Tmax.
2The conversion ratio of 10mg parenteral morphine = 30mg oral morphine is based on clinical experience in patients with chronic pain. The conversion ratio of 10mg parenteral morphine = 60mg oral morphine is based on a potency study in acute pain.
3See literature for conversion of fentanyl transdermal patch, buccal tablets, buccal soluble film, sublingual tablets, units for transmucosal administration, and nasal spray.
4Hydrocodone not available as a single entity product.
Feldman MD, Christensen JF, Satterfield JM. Behavioral Medicine: A Guide For Clinical Practice, Fourth Edition. New York, NY: McGraw-Hill Education; 2014.