FDA-Approved Prostate Cancer Treatments

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FDA-Approved Prostate Cancer Treatments - MPR
Generic Brand Strength Form Usual Dose
Emcyt 140mg caps 14mg/kg in 3 or 4 divided doses
2mg/mL soln for IV infusion after dilution 12−14mg/m² every 21 days
abiraterone acetate Yonsa 125mg tabs CRPC: 500mg once daily (in combination with methylprednisolone 4mg twice daily). Give concurrent GnRH analog or should have had bilateral orchiectomy.
Zytiga 250mg, 500mg tabs 1g once daily on an empty stomach (in combination with oral prednisone 5mg twice daily [CRPC] or 5mg once daily [CSPC]). Give concomitant GnRH analog or should have had bilateral orchiectomy.
apalutamide Erleada 60mg tabs CRPC: 240mg once daily. Give concurrent GnRH analog or should have had bilateral orchiectomy.
Casodex 50mg tabs 50mg daily
Xtandi 40mg caps CRPC: 160mg once daily. Give concurrent GnRH analog or should have had bilateral orchiectomy.
flutamide 125mg caps 250mg every 8hrs
nilutamide Nilandron 150mg tabs 300mg once daily for 30days, then 150mg once daily, starting day of or day after surgical castration
docetaxel Taxotere 40mg/mL soln for IV infusion after dilution 75mg/m² once every 3wks
cabazitaxel Jevtana 60mg/
soln for IV infusion after dilution 25mg/m² once every 3wks with oral prednisone 10mg daily during treatment
sipuleucel‑T Provenge Minimum 50 million autolo-
gous CD54+ cells activated with PAP-GM-CSF/
250mL dose
susp for IV infusion Autologous use only. Obtain product release from manufacturer, match patient identity on product and Cell Product Disposition form, check expiration date and time on product before infusing. Premedicate 30min before infusion with acetaminophen and antihistamine. Give three doses at 2‑wk intervals. For each dose: Give entire contents of bag by IV infusion over 60min; do not use filter; do not use if clumps do not disperse with gentle mixing. Observe patient for at least 30min after infusion. May interrupt or slow infusion if acute transfusion reaction occurs; do not restart if product at room temp for >3hrs.
conjugated estrogens Premarin 0.3mg, 0.45mg, 0.625mg, 0.9mg, 1.25mg tabs 1.25−2.5mg 3 times daily
estradiol Estrace 0.5mg, 1mg, 2mg scored tabs 1−2mg 3 times daily
estradiol valerate Delestrogen 10mg/mL, 20mg/mL, 40mg/mL soln for IM inj 30mg or more every 1 or 2wks
estrogens, esterified Menest 0.3mg, 
0.625mg, 1.25mg, 2.5mg
tabs 1.25−2.5mg 3 times daily
goserelin acetate Zoladex 3.6mg SC implant Advanced prostate cancer: One 3.6mg implant every 28 days or one 10.8mg implant every 12wks.
Stage B2-C prostatic carcinoma (in combination with flutamide): Initially one 3.6mg implant, followed in 28 days by one 10.8mg implant; or may use one 3.6mg implant every 28 days. Treat 8wks prior to and during radiotherapy.
3-Month 10.8mg
histrelin acetate Vantas 50mg SC implant Insert 1 implant SC in the inner aspect of the upper arm; remove or replace after 12mos
leuprolide acetate 5mg/mL soln for 
SC inj
1mg SC daily
Eligard 7.5mg, 22.5mg, 30mg, 45mg ext-rel susp for SC inj 7.5mg SC once per month; or 22.5mg SC once every 3mos; or 30mg SC once every 4mos; or 45mg SC once every 6mos
Lupron Depot 7.5mg 7.5mg depot susp for IM inj 7.5mg IM once a month (4wks); or 22.5mg IM once every 3mos (12wks); or 30mg IM once every 4mos (16wks); or 45mg IM once every 6mos (24wks)
Lupron Depot–3month 22.5mg 22.5mg
Lupron Depot–4month 30mg 30mg
Lupron Depot - 6month 45mg 45mg
triptorelin pamoate Trelstar 3.75mg, 11.25mg, 22.5mg pwd for IM inj after reconsti-
3.75mg every 4wks or 11.25mg every 12wks or 22.5mg every 24wks
degarelix Firmagon 80mg/
vial, 120mg/
pwd for SC inj after reconsti-
Give by SC inj in abdomen once every 28 days; avoid waist and rib areas. Two 120mg injections once, then one 80mg inj once every 28 days.

KEY: CRPC = castration-resistant prostate cancer; CSPC = castration-sensitive prostate cancer

*For palliative treatment only.
Not an inclusive list of medications and/or doses. Please see drug monograph at www.eMPR.com and/or contact company for full drug labeling.

(Rev. 9/2018)

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