Splenomegaly with platelet sequestration
Increased platelet destruction by an immune mechanism; can occur as a result of:
Heparin-induced thrombocytopenia (HIT)
Idiopathic or immune thrombocytopenic purpura (ITP)
Drug (other than heparin)-induced thrombocytopenia
Post-transfusion purpura (PTP)
Increased platelet destruction by non-immune mechanisms, as caused by:
Hemolytic uremic syndrome (HUS)
Thrombotic thrombocytopenic purpura (TTP)
Decreased platelet production most often occurs after exposure to drugs (e.g., chemotherapeutic agents) that suppress synthesis of new platelets or by infiltration of the marrow by tumor or other structures.
Suggested Additional Lab Testing
Platelet count establishes presence or absence of thrombocytopenia; 100,000 functional platelets/µL is usually considered adequate for any challenge to hemostasis.
Workup for DIC:
D-dimer or FDP
Peripheral blood smear to check for schistocytes
Test for HIT:
Most often available is ELISA for antibody to platelet factor 4/heparin complex
ITP is a diagnosis of exclusion.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Renal and Urology News Articles
- Medication Adherence Low in Gout Patients Initiating Allopurinol
- Trials Supporting FDA Approval of Breakthrough Drugs Examined
- FDA Approves Enzalutamide for Nonmetastatic Castration-Resistant Prostate Cancer
- Urine Cytology May Not Improve Hematuria Evaluation for Bladder Cancer
- Bladder Hydrodistention May Ease Nocturia in Interstitial Cystitis
Sign Up for Free e-newsletters
NEPHROLOGY & UROLOGY NEWS
- Acute Kidney Injury (AKI)
- Chronic Kidney Disease (CKD)
- Contrast Nephropathy
- Cardiovascular Disease (CVD)
- Diabetic Nephropathy
- End-stage Renal Disease (ESRD)
- Lupus Nephritis
- Peritoneal Dialysis
- Secondary Hyperparathyroidism (SHPT)