Positive Serologic Test for Helicobacter pylori

Differential Diagnosis

Gastric ulcer

Duodenal ulcer

Suggested Additional Lab Testing

For gastric ulcer:

  • Endoscopy to visualize the ulcer; biopsy of the lesion is recommended to determine if patient has gastric adenocarcinoma.

  • Rapid urease test of biopsy material (CLO test) verifies the presence of active infection.

For duodenal ulcer disease:

  • Urea breath test is a sensitive and specific test for detection of active infection without the use of biopsy in patients with uncomplicated duodenal ulcer.

  • If a biopsy is performed, the CLO test, if positive, verifies the presence of active infection.

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