Nephrotic Syndrome Found to Raise Ischemic Stroke Risk
Taiwan study reveals a 38% increased risk of ischemic stroke among patients with nephrotic syndrome.
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SAN DIEGO—Nephrotic syndrome is associated with an increased risk of ischemic stroke, according to study findings presented at the American Society of Nephrology's Kidney Week 2018 meeting.
In a retrospective nationwide cohort study using registry data from the National Health Insurance Research Database in Taiwan, Ming-Ju Wu, MD, PhD, and Tung-Min Yu, MD, PhD, of Taichung Veterans General Hospital in Taichung, Taiwan, identified 3496 patients with nephrotic syndrome ranging in age from 18 to 110 years and 13,984 control patients without nephrotic syndrome matched by age, sex, and Charlson Comorbidity Index.
The 3-year incidence rates of ischemic stroke in the nephrotic syndrome and control groups were 25% and 15.9%, respectively. Compared with controls, patients with nephrotic syndrome had a significant 37% increased risk of stroke overall, a significant 38% increased risk of ischemic stroke, and a non-significant 26% increased risk of hemorrhagic stroke after adjusting for age, sex, and comorbidities.
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Wu MJ, Yu TM. Nephrotic syndrome is significantly associated with increased risk of ischemic stroke. Presented at the American Society of Nephrology's 2018 Kidney Week meeting in San Diego, Oct. 23-28. Abstract FR-OR084.