Phosphate Binder Use Tied With Better Survival
Phosphate binder use is associated with a 25% and 37% decreased risk of death from infection-related causes and all-causes, respectively, compared with non-users.
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NEW ORLEANS—Phosphate binder therapy may decrease the risks for infection-related and all-cause death, Japanese researchers reported at Kidney Week 2017.
Shunsuke Yamada, MD, of Kyushu University, and his team analyzed mortality among 2926 hemodialysis (HD) patients from 39 centers in the Q-Cohort Study. Over nearly 4 years of follow-up, 106 patients died from infection. Phosphate binder users had a significant 25% and 37% reduce risk of dying from infection-related causes and all causes, respectively, than patients not taking the drugs.
Results held even after the researchers adjusted for potential confounders. Phosphate binder users had higher body mass index, normalized protein catabolic rate, serum creatinine, and albumin levels than those who did not take the drugs.
“Use of phosphate binders can reduce the risk of infection-related death as well as all-cause death in hemodialysis patients, probably by maintaining good nutritional status,” Dr Yamada told Renal & Urology News.
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1. Yamada S, Tokumoto M, Taniguchi M. Association between use of phosphate-binders and infection-related mortality in hemodialysis patients; the Q-Cohort Study. Presented at Kidney Week 2017 in New Orleans (Oct. 31-Nov. 5). Abstract TH-PO1044.