High Uric Acid Raises ESRD Risk
The highest vs. lowest quartile of serum uric acid is associated with a 3.4-fold increased risk of end-stage renal disease.
SAN DIEGO—High serum uric acid levels are an independent risk factor for end-stage renal disease (ESRD), researchers reported at Kidney Week.
In a 6-year population-based cohort study that enrolled 23,712 individuals older than 20 years, investigators found that subjects in the highest quartile of serum uric acid level (above 7.3 mg/dL) had a 3.4-fold increased risk of ESRD compared with those in the lowest quartile (less than 5.2 mg/dL) after adjusting for potential confounders. Individuals in the second and third quartiles had a significant 1.8 and 2.4 times increased risk, respectively.
The study, by Ouppatham Supasyndh, MD, and colleagues at Phramongkutklao College of Medicine in Bangkok, Thailand, showed that individuals with a serum uric acid level of 7 mg/dL or higher had a 5.7-fold increased risk of ESRD compared with those who had a lower level. In addition, the study found that each 1 mg/dL increase in serum uric acid was associated with a 2.4 mL/min/1.73 m2 decline in estimated glomerular filtration rate (eGFR).