Kidney Cancer

Tivozanib Offers Superior Outcomes in Refractory Metastatic Renal Cell Carcinoma

Tivozanib Offers Superior Outcomes in Refractory Metastatic Renal Cell Carcinoma

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Compared with sorafenib, tivozanib was associated with improved progression-free survival and objective response rate, researchers reported.

First-Line Pembrolizumab Shows Promise in Non-Clear Cell RCC

First-Line Pembrolizumab Shows Promise in Non-Clear Cell RCC

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About 25% of patients with previously untreated advanced non-clear cell renal cell carcinoma had an objective response to pembrolizumab.

Combo Superior to Sunitinib in Advanced Renal Cell Carcinoma

Combo Superior to Sunitinib in Advanced Renal Cell Carcinoma

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Avelumab-axitinib regimen offers better progression-free survival and responses than sunitinib for patients with previously untreated advanced RCC, regardless of risk group or PD-L1 status.

Early Tumor Shrinkage With Cabozantinib Improves Survival in RCC

Early Tumor Shrinkage With Cabozantinib Improves Survival in RCC

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New analysis shows that early tumor shrinkage with cabozantinib is associated with longer survival compared with everolimus.

Nivolumab-Ipilimumab Survival Benefit in Advanced RCC Confirmed

Nivolumab-Ipilimumab Survival Benefit in Advanced RCC Confirmed

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Patients with treatment-naive, intermediate- and poor-risk advanced RCC continue to have superior overall survival with the dual ICI regimen compared with sunitinib alone.

Two-Drug Combination Superior to Sunitinib in Patients With Untreated Advanced Renal Cell Carcinoma

Two-Drug Combination Superior to Sunitinib in Patients With Untreated Advanced Renal Cell Carcinoma

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As first-line therapy for locally advanced or metastatic renal cell carcinoma, pembrolizumab plus axitinib offers longer overall and progression-free survival compared with sunitinib.

Obesity-Related Cancers Rising Among Younger Adults

Obesity-Related Cancers Rising Among Younger Adults

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Kidney cancer and some other cancers tied to obesity are increasing the most rapidly among individuals younger than 50.

First-Line TKIs Less Effective in Non-Clear-Cell Renal Cell Carcinoma

First-Line TKIs Less Effective in Non-Clear-Cell Renal Cell Carcinoma

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First-line treatment of metastatic renal cell carcinoma with tyrosine kinase inhibitors is associated with worse progression-free and overall survival in patients with non-clear-cell vs clear-cell histology.

Surgery May Not Be Most Appropriate Frontline Tx in mRCC

Surgery May Not Be Most Appropriate Frontline Tx in mRCC

Evidence suggests that starting on systemic drug therapy immediately may be the best approach for some patients with metastatic RCC.

Personalized Tx May Extend Life in CKD With Small Renal Tumors

Personalized Tx May Extend Life in CKD With Small Renal Tumors

Routine partial nephrectomy yielded longest life expectancy in patients with normal renal function.

Kidney Stones Up Kidney Cancer Risk

Kidney Stones Up Kidney Cancer Risk

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A history of kidney stones is associated with an increased risk of papillary renal cell carcinoma and upper tract urothelial carcinoma, according to a large prospective study.

Royal Jelly May Ease Adverse Effects of RCC Drug Therapy

Royal Jelly May Ease Adverse Effects of RCC Drug Therapy

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In a small study, sunitinib recipients who took royal jelly, a substance produced by worker honeybees for queen bees, were less likely to experience fatigue and anorexia than those who took placebo.

Karyopherin a2 May Be Prognostic Indicator in Renal Cell Carcinoma

Karyopherin a2 May Be Prognostic Indicator in Renal Cell Carcinoma

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Researchers theorize that KPNA2 expression could be used in the future to stratify risk groups among patients with renal cell carcinoma (RCC).

Changes in Renal Cell Carcinoma Pathologic Staging and Histologic Grading

Changes in Renal Cell Carcinoma Pathologic Staging and Histologic Grading

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A review article examines the challenges in pathologic staging and grade reporting for patients with renal cell carcinoma.

The Rapidly Evolving Landscape for mRCC

The Rapidly Evolving Landscape for mRCC

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Incredible progress is being made in kidney cancer treatment.

Lymphadenectomy Offers No Survival Benefit in Nonmetastatic RCC

Lymphadenectomy Offers No Survival Benefit in Nonmetastatic RCC

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Lymph node dissection did not influence overall survival even among patients with clinically positive nodal disease.

Front-Line Combo Found Superior for Advanced RCC

Front-Line Combo Found Superior for Advanced RCC

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Avelumab plus axitinib is associated with longer progression-free survival compared with sunitinib as first-line therapy in patients with advanced renal cell carcinoma.

ASTRO: Stereotactic Ablative RT OK for RCC in Solitary Kidneys

ASTRO: Stereotactic Ablative RT OK for RCC in Solitary Kidneys

Local control, cancer-specific survival at 2 years similar for patients with solitary, bilateral kidneys

Later-Stage RCC at Diagnosis Less Likely in Blacks

Later-Stage RCC at Diagnosis Less Likely in Blacks

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At the time of diagnosis of renal cell carcinoma, blacks had 33% lower odds of regional disease compared with whites, a new study found.

ESRD Risk Following Kidney Cancer Surgery Characterized

ESRD Risk Following Kidney Cancer Surgery Characterized

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Australian study shows that end-stage renal disease develops in 1.7% of patients with 3 years of undergoing nephrectomy for kidney cancer.

Renal Biopsy Rarely Leads to Upstaging to Perinephric Fat Involvement

Renal Biopsy Rarely Leads to Upstaging to Perinephric Fat Involvement

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Study of patients with clinical T1a renal cell carcinoma shows that those who undergo renal mass biopsy have only a 1.2% rate of upstaging to pT3a perinephric fat involvement.

Radical, Partial Nephrectomy Do Not Differ in Survival Outcomes

Radical, Partial Nephrectomy Do Not Differ in Survival Outcomes

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Propensity score-matched analysis shows that radical and partial nephrectomy for cT1 renal cell carcinoma are associated with similar cancer-specific and all-cause mortality, a study found.

Risk Factors for Bone Metastases at RCC Diagnosis Identified

Risk Factors for Bone Metastases at RCC Diagnosis Identified

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Older age, male sex, and higher T stage are associated with an increased risk of having bone metastases at initial diagnosis of renal cell carcinoma, study finds.

Partial Nephrectomy for Small Renal Tumors Offers Survival Edge

Partial Nephrectomy for Small Renal Tumors Offers Survival Edge

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Partial vs radical nephrectomy is associated with an overall survival advantage among patients with RCC tumors 4 cm or smaller and many patients with larger tumors.

NLR Predicts Survival After Cytoreductive Nephrectomy+Thrombectomy

NLR Predicts Survival After Cytoreductive Nephrectomy+Thrombectomy

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A neutrophil-lymphocyte ratio below 4 is associated with significantly longer survival among patients with non-poor-risk metastatic renal cell carcinoma.

Diabetes Population Has Higher Incidences of Bladder, Kidney Cancer

Diabetes Population Has Higher Incidences of Bladder, Kidney Cancer

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Finnish study of individuals with type 2 diabetes reveals a 17% and 42% higher incidence of bladder and kidney cancer, respectively, compared with the general population.

High BMI at Start of Advanced RCC Systemic Therapy Ups Survival Odds

High BMI at Start of Advanced RCC Systemic Therapy Ups Survival Odds

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In a German study of patients starting first-line systemic therapy for advanced renal cell carcinoma, patients with a low BMI were twice as likely to die as those with a high BMI.

New Study Supports Recent AUA Guidelines for Small Renal Masses

New Study Supports Recent AUA Guidelines for Small Renal Masses

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Prospective study at Johns Hopkins shows excellent oncologic outcomes and preserved mental quality of life for all patients regardless of management strategy, with worse renal function after radical nephrectomy.

Alternative Sunitinib Regimen for Advanced RCC Proposed

Alternative Sunitinib Regimen for Advanced RCC Proposed

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A "weekday-on and weekend-off regimen" improves relative dose intensity compared with the conventional regimen, a study found.

Off-Clamp Partial Nephrectomy Better for Preserving Renal Function

Off-Clamp Partial Nephrectomy Better for Preserving Renal Function

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In a study, the off-clamp approach to partial nephrectomy also was associated with lower risk for acute kidney injury.

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