Partial Nephrectomy Improves Survival in cT1b RCC Cases

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Partial nephrectomy was associated with decreased odds of death versus radical nephrectomy among patients with cT1b but not cT2 renal cell carcinoma.
Partial nephrectomy was associated with decreased odds of death versus radical nephrectomy among patients with cT1b but not cT2 renal cell carcinoma.

Partial nephrectomy is associated with significantly better survival than radical nephrectomy for cT1b renal cell carcinoma (RCC), but survival outcomes associated with both surgical approaches are similar for patients with cT2 RCC, new data suggest.

Partial nephrectomy is the standard management for cT1a RCC, and there is a basis for expanding its indications to larger tumors (cT1b and cT2), investigators noted.

To explore survival and perioperative outcomes of PN versus radical nephrectomy (RN) for cT1b and cT2 RCC, Vivek Venkatramani and colleagues at the University of Miami Miller School of Medicine used the National Cancer Data Base to identify patients with these cancers who underwent either procedure from 1994 to 2013. Among patients with cT1b RCC, those who underwent PN had a significant 20% lower odds of death compared with those who underwent RN, Dr Venkatramani's team reported online ahead of print in Urologic Oncology. The investigators found no significant difference in overall survival rates between the surgical approaches among patients with cT2 RCC.

In addition, unplanned hospital readmission at 30 days was significantly more common in the PN than RN groups (4.2% vs 2.9%), but the groups had similar 30- and 90-day mortality rates.

Reference

Venkatramani V, Koru-Sengul T, Miao F, et al. A comparison of overall survival and perioperative outcomes between partial and radical nephrectomy for cT1b and cT2 renal cell carcinoma—Analysis of a national  cancer registry. Urol Oncol. 2017; published online ahead of print.

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