Kidney Cancer News Archive

Robotics Involved in Most Urologic Cancer Surgeries

Robotics Involved in Most Urologic Cancer Surgeries

In 2015, 69% of surgeries for prostate, bladder, and kidney cancer were performed with robotic assistance, a new meta-analysis shows.

Sunitinib Alone or After Surgery for mRCC Offers Similar Outcomes

Sunitinib Alone or After Surgery for mRCC Offers Similar Outcomes

New findings from the CARMENA trial contradict previous research showing better survival from cytoreductive nephrectomy followed by targeted therapy.

Urothelial Cell Carcinoma Linked to High Albumin Excretion

Urothelial Cell Carcinoma Linked to High Albumin Excretion

Patients in the highest quintile of urinary albumin excretion had a 4.5-fold increased risk of urothelial cell carcinoma vs those in quintiles 1-3.

Readmission Risk Factors for Radical Nephrectomy Patients Identified

Readmission Risk Factors for Radical Nephrectomy Patients Identified

Race, procedure and insurance type, sex, surgeon volume, and hospital size influence the risk of readmission among patients undergoing radical nephrectomy, study finds.

Delayed mRCC Targeted Therapy Does Not Worsen Survival

Delayed mRCC Targeted Therapy Does Not Worsen Survival

In a study of mRCC patients who received targeted therapy (TT) following cytoreductive nephrectomy, mortality risk did not differ significantly between delayed and early TT.

Racial Disparities in RCC Survival Driven by Socioeconomic Factors

Racial Disparities in RCC Survival Driven by Socioeconomic Factors

Black patients tended to have lower incomes, less education, longer delays to treatment, greater comorbidity burden.

Partial vs Radical Nephrectomy Lowers Elderly Patient Mortality Risk

Partial vs Radical Nephrectomy Lowers Elderly Patient Mortality Risk

Study shows that partial nephrectomy for small renal tumors is associated with lower risk of cancer-specific and other-cause mortality in patients aged 75 years and older.

Smoking Ups Bladder Cancer Risk, Lowers Prostate Cancer Risk

Smoking Ups Bladder Cancer Risk, Lowers Prostate Cancer Risk

Men and women who smoke are at 2.3-fold and 2.7-fold increased risk of bladder cancer compared with non-smokers.

Odds of Prescribing Drugs Up With Doc Receipt of Payments

Odds of Prescribing Drugs Up With Doc Receipt of Payments

Doctors who receive general payment for cancer drug more likely to prescribe drug marketed by company.

Relative Visceral Fat Indicates Mortality Risk for Women With RCC

Relative Visceral Fat Indicates Mortality Risk for Women With RCC

An evaluation of patients with clear cell renal cell carcinoma revealed greater risk of death for female patients with high relative visceral fat area (rVFA), highlighting the significance of metabolic differences between men and women.

Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors

Myocarditis Rare Side Effect of Immune Checkpoint Inhibitors

Myocarditis with ICIs may be more common than initially thought; responds to higher steroid dosages

Older Age May Up Risk for RCC-Related Death After Surgery

Older Age May Up Risk for RCC-Related Death After Surgery

The risk of dying from pT1a renal cell carcinoma after partial or radical nephrectomy increases along with patient age.

Nivolumab Plus Ipilimumab Better for Advanced RCC

Nivolumab Plus Ipilimumab Better for Advanced RCC

Among intermediate- and poor-risk patients, the risk for death was 37% lower with nivolumab plus ipilimumab than with sunitinib.

Robotic PN May Offer Better Outcomes Than RFA for T1a RCC

Robotic PN May Offer Better Outcomes Than RFA for T1a RCC

Two-year recurrence-free survival was 100% vs 95.2% among robotic surgery and radiofrequency ablation patients, respectively.

Small Renal Masses Initially Grow at Variable Rates

Small Renal Masses Initially Grow at Variable Rates

Not reliable predictor of adverse outcomes in those under active surveillance; less variability over time

First-line Pazopanib May Improve Outcomes in Advanced RCC

First-line Pazopanib May Improve Outcomes in Advanced RCC

Treatment-naïve patients with advanced clear-cell renal cell carcinoma had significantly longer progression-free survival when treated with pazopanib instead of temsirolimus.

Metastatic RCC Treatment With Nivolumab Confirmed Safe, Efficacious

Metastatic RCC Treatment With Nivolumab Confirmed Safe, Efficacious

The safety and efficacy of nivolumab for treating metastatic renal cell carcinoma is comparable to that found in the CheckMate 025 trial.

Axitinib-Pembrolizumab Combo Promising for Advanced RCC

Axitinib-Pembrolizumab Combo Promising for Advanced RCC

In a phase Ib study, dual therapy with axitinib and pembrolizumab was well tolerated and demonstrated antitumor activity in treatment-naïve patients with advanced renal cell carcinoma.

Cytoreductive Nephrectomy May Up Survival in Papillary mRCC

Cytoreductive Nephrectomy May Up Survival in Papillary mRCC

Study reveals a 38% decreased risk of death in patients with papillary metastatic renal cell carcinoma who undergo cytoreductive nephrectomy vs those who do not.

Metastatic Kidney Cancer Outcomes Improved With Combined Therapy

Metastatic Kidney Cancer Outcomes Improved With Combined Therapy

Immunotherapy with atezolizumab plus targeted therapy with bevacizumab improves progression-free survival better than sunitinib in patients with untreated metastatic renal cell carcinoma.

Urologic Cancer Surgery Readmission Rate Highest for RC

Urologic Cancer Surgery Readmission Rate Highest for RC

In a study, nearly 20% of radical cystectomy patients were readmitted for complications within 90 days compared with 1.9% and 5.9% for radical prostatectomy and radical nephrectomy, respectively.

Robotic Partial Nephrectomy Feasible for Larger Kidney Tumors

Robotic Partial Nephrectomy Feasible for Larger Kidney Tumors

No greater risks for upstaging or positive surgical margins were observed among patients who underwent RPN for cT2a tumors over the short term.

Kidney Cancer Progression Linked to Preop Cardiovascular Biomarkers

Kidney Cancer Progression Linked to Preop Cardiovascular Biomarkers

Elevated serum levels of BNP and NT-proBNP prior to nephrectomy are associated with an increased likelihood of RCC progression.

RCC Treatment Costs Could Negatively Affect Health

RCC Treatment Costs Could Negatively Affect Health

Access to treatment should be considered as important as the research leading to clinical improvements.

Radical Nephrectomy Linked With Worse Kidney Function, Survival

Radical Nephrectomy Linked With Worse Kidney Function, Survival

Patients who underwent radical nephrectomy had 2-fold greater decline in eGFR decline and 2-fold greater mortality compared with those who had a partial nephrectomy.

Cabozantinib Improves Survival, Response in Bone-metastatic RCC

Cabozantinib Improves Survival, Response in Bone-metastatic RCC

Patients who received cabozantinib were also less likely to have skeletal-related events (23% vs 29% with everolimus).

SABR for Renal Cell Carcinoma Offers Excellent Outcomes

SABR for Renal Cell Carcinoma Offers Excellent Outcomes

Stereotactic ablative radiotherapy is associated with high 2- and 4-year rates of local cancer control and progression-free and cancer-specific survival.

Conversion of Robotic Partial to Radical Nephrectomy Is Uncommon

Conversion of Robotic Partial to Radical Nephrectomy Is Uncommon

In a multinational, prospective study, just 5% of cases converted.

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Adverse Events Up for Autoimmune Disease Pts on Checkpoint Inhibitors

Most patients with cancer, autoimmune disease have improvement in events without discontinuing therapy.

Fatigue Tied With Sorafenib, Sunitinib Use in Renal Cell Carcinoma

Fatigue Tied With Sorafenib, Sunitinib Use in Renal Cell Carcinoma

Although TKIs improve outcomes, they are still associated with toxicities common with cancer therapies, such as fatigue.

Partial Nephrectomy Improves Survival in cT1b RCC Cases

Partial Nephrectomy Improves Survival in cT1b RCC Cases

Partial nephrectomy was associated with decreased odds of death versus radical nephrectomy among patients with cT1b but not cT2 renal cell carcinoma.

FDA Approves Cabometyx for First-Line Treatment of Advanced RCC

FDA Approves Cabometyx for First-Line Treatment of Advanced RCC

Treatment with cabozantinib led to a clinically meaningful improvement in progression-free survival compared with sunitinib.

Cytoreductive Nephrectomy Benefits for Metastatic RCC Demonstrated

Cytoreductive Nephrectomy Benefits for Metastatic RCC Demonstrated

Patients who underwent cytoreductive nephrectomy for metastatic non-clear cell renal cell carcinoma had a significantly decreased risk of cancer-related mortality.

Kidney Cancer Bone Metastasis Predictors Id'd

Kidney Cancer Bone Metastasis Predictors Id'd

Levels of alkaline phosphatase, calcium, and hemoglobin can independently predict bone metastasis in patients with renal cell carcinoma, Chinese investigators report.

Cytoreductive Nephrectomy Improves Survival in mRCC

Cytoreductive Nephrectomy Improves Survival in mRCC

Propensity score matching showed a 5.8 month survival advantage for initial CN vs initial systematic therapy.

FDA Approves Sunitinib for Adjuvant Treatment of RCC

FDA Approves Sunitinib for Adjuvant Treatment of RCC

At 5 years, 59.3% of patients treated with sunitinib were free from recurrence versus 51.3% who received placebo.

Radical Nephrectomy Costs, Operating Time Greater With Robotics

Radical Nephrectomy Costs, Operating Time Greater With Robotics

Robotic-assisted radical nephrectomy (RN) is associated with higher hospital costs and prolonged operating time compared with laparoscopic RN.

Blood Transfusion Predicts Worse Outcomes After Nephrectomy for RCC

Blood Transfusion Predicts Worse Outcomes After Nephrectomy for RCC

Perioperative blood transfusion is associated with increased risks of tumor recurrence, metastatic progression, and cancer-related mortality.

Overweight-Related Cancers Common in the US

Overweight-Related Cancers Common in the US

40% of cancer diagnoses tied to extra weight; rate higher in older individuals, females.

RCC Subtypes Affect Post-Surgery Cancer-Related Mortality Risk

RCC Subtypes Affect Post-Surgery Cancer-Related Mortality Risk

Patients with papillary versus clear cell renal cell carcinoma have a 24% decreased risk of dying from their cancer.

CKD Risk Lower With Partial Nephrectomy

CKD Risk Lower With Partial Nephrectomy

In a study, partial nephrectomy was associated with a 66% lower risk for stage 4 or higher CKD versus radical nephrectomy.

Various Neurological Complications Tied to Anti-PD-1 Therapy

Various Neurological Complications Tied to Anti-PD-1 Therapy

The researchers found that 2.9% of the 347 patients treated with anti-PD-1 monoclonal antibodies developed subacute onset of neurological complications.

FDA Approves First Biosimilar for Kidney Cancer Treatment

FDA Approves First Biosimilar for Kidney Cancer Treatment

Mvasi, which is approved to treat colorectal, lung, brain, kidney, and cervical cancer, was found to be biosimilar to the drug Avastin.

Immunotherapy Superior to Sunitinib for Front-Line mRCC Treatment

Immunotherapy Superior to Sunitinib for Front-Line mRCC Treatment

Checkpoint inhibitor combination of nivolumab plus ipilimumab improved progression-free and overall survival compared with sunitinib.

Upfront Cabozantinib for Advanced RCC Improves Outcomes

Upfront Cabozantinib for Advanced RCC Improves Outcomes

Cabozantinib reduced the risk of disease progression or death compared with sunitinib among patients with previously untreated advanced renal cell carcinoma.

Early NLR Changes Predict mRCC Immunotherapy Outcomes

Early NLR Changes Predict mRCC Immunotherapy Outcomes

Rises and decreases in neutrophil-to-lymphocyte ratio at 6 weeks after treatment with anti-PD-1/PD-L1 immune checkpoint blockade is associated with progression-free and overall survival.

Energy Dense Diet Increases Obesity-Related Cancer Risk

Energy Dense Diet Increases Obesity-Related Cancer Risk

The increased risk for obesity-related cancer was seen among women who were normal weight at enrollment.

Geriatric Consultation Uncommon in Kidney Cancer Surgery

Geriatric Consultation Uncommon in Kidney Cancer Surgery

Participant age and comorbidity burden appeared to be consistent determinants of use of services, although hospital-level variation was also noted.

Targeted Multigene Panel Testing Useful for Hereditary Kidney Cancer

Targeted Multigene Panel Testing Useful for Hereditary Kidney Cancer

The most commonly altered genes were folliculin and fumarate hydratase in 1.8% and 1.3%, respectively.

Type of Long-term Response to Targeted mRCC Therapy Affects Outcomes

Type of Long-term Response to Targeted mRCC Therapy Affects Outcomes

Patients who have a complete response to 2 or more years of anti-VEGF treatment have the best progression-free and overall survival.

BMI, Belly Fat Suggest Obesity-Related Cancer Risk

BMI, Belly Fat Suggest Obesity-Related Cancer Risk

BMI and location of excess body fat on the body are good indicators of obesity-related cancer risk.

Renal, Bladder Cancer Linked to Physical Inactivity

Renal, Bladder Cancer Linked to Physical Inactivity

Renal and bladder cancer patients were, respectively, 77% and 73% more likely to report lifetime physical inactivity than controls without cancer.

AUA Releases Updated Renal Mass Guidelines

AUA Releases Updated Renal Mass Guidelines

The document spells out in greater detail the criteria for radical and partial nephrectomy and for placing patients on active surveillance.

Early CRP Response to mRCC Drugs Predicts Survival

Early CRP Response to mRCC Drugs Predicts Survival

Changes in C-reactive protein levels 4 weeks after starting sunitinib or sorafenib treatment are associated with overall and progression-free survival.

AS Safe for Cystic Renal Masses in Selected Patients

AS Safe for Cystic Renal Masses in Selected Patients

In a single-center study, 24% of patients crossed over to treatment and 95% of patients were alive after 5 years of follow-up.

RCC Patients May Benefit from Nivolumab After Disease Progression

RCC Patients May Benefit from Nivolumab After Disease Progression

Nivolumab treatment beyond disease progression results in reductions in tumor burden, study finds.

Recurrence of Low-Risk RCC Uncommon After Surgery

Recurrence of Low-Risk RCC Uncommon After Surgery

In a study, the 5-year risk of recurrence was 4.8%, 18.1%, and 46.3% for patients with low-, intermediate-, and high-risk disease.

Kidney Cancer Survival Better Among Metformin Users

Kidney Cancer Survival Better Among Metformin Users

Patients who used the drug had a 38% lower risk of dying from kidney cancer than non-users, meta-analysis shows.

Targeted Therapies for Advanced RCC Improve Real-World Survival

Targeted Therapies for Advanced RCC Improve Real-World Survival

Overall survival among patients receiving first-line targeted therapy for advanced renal cell carcinoma increased significantly from 2006 to 2012.

Kidney Cancer Linked to Obesity

Kidney Cancer Linked to Obesity

Study also finds associations between adiposity and 10 other cancers, particularly digestive and hormone-related malignancies.

Broad-spectrum Antibiotics May Reduce Survival in mRCC

Broad-spectrum Antibiotics May Reduce Survival in mRCC

The researchers found that patients treated with ABT had decreased progression-free survival compared with those not receiving ATB.

Biologics Combo Shows Promise As First-Line mRCC Therapy

Biologics Combo Shows Promise As First-Line mRCC Therapy

In a phase 2 trial, atezolizumab plus bevacizumab improved PFS versus sunitinib in patients with renal cell carcinoma expressing PD-L1.

Sunitinib Dose Escalation May Benefit mRCC Patients

Sunitinib Dose Escalation May Benefit mRCC Patients

Added progression-free survival and prolonged overall survival possible, according to investigators.

Kidney Cancer Brain Metastases Not On the Rise

Kidney Cancer Brain Metastases Not On the Rise

Researchers develop a model to predict which patients are more likely to harbor brain metastases at cancer diagnosis.

Single RCC Bone Metastasis Predicts Better Survival

Single RCC Bone Metastasis Predicts Better Survival

Bone surgery should be considered in patients with solitary bone metastasis and no concomitant visceral metastases, according to investigators.

Metabolic Profiles May Distinguish RCC From Benign Masses

Metabolic Profiles May Distinguish RCC From Benign Masses

In a pilot study, metabolomic analyses of serum and urine showed a high level of predictive ability.

Guidelines Issued for Managing Small Renal Masses

Guidelines Issued for Managing Small Renal Masses

All patients with an SRM should be considered for a biopsy when the results may alter management.

Benign Disease Found in 14% of PN Cases

Benign Disease Found in 14% of PN Cases

The most common types of benign pathology were oncocytoma, angiomyolipoma, and complex cysts.

Office-Based Renal Mass Biopsy Safe

Office-Based Renal Mass Biopsy Safe

In a study, only 3 of 108 patients experienced complications, all of which were minor and required no hospitalization or further intervention.

Robotic Nephrectomy for Localized RCC On The Rise

Robotic Nephrectomy for Localized RCC On The Rise

In 2013, nearly one third of all minimally invasive radical nephrectomies were performed with robotic assistance.

Study: Older Age Should Not Preclude Partial Nephrectomy

Study: Older Age Should Not Preclude Partial Nephrectomy

Partial and radical nephrectomy were associated with similar cancer-specific and overall survival in elderly patients.

CB-839 Drug Promising for Clear Cell, Papillary Renal Cell Cancer

CB-839 Drug Promising for Clear Cell, Papillary Renal Cell Cancer

In the 15 patients in the study, the dual treatment controlled tumors in 93% of the patients, who had either clear cell or papillary renal cell cancer.

Age at Cancer Diagnosis Predicts Cardiac Risk

Age at Cancer Diagnosis Predicts Cardiac Risk

Cancer patients diagnosed in their teens had a more than 4-fold higher risk of death from cardiac disease than patients who didn't have cancer.

Robotic Partial Nephrectomy Offers Better Morbidity Than Laparoscopic

Robotic Partial Nephrectomy Offers Better Morbidity Than Laparoscopic

Robotic partial nephrectomy confers a superior morbidity profile compared to laparoscopic partial nephrectomy.

Renal-Cell Cancer Disease-Free Survival Up With Sunitinib

Renal-Cell Cancer Disease-Free Survival Up With Sunitinib

Among patients with clear-cell renal-cell carcinoma at high risk for tumor recurrence, the duration of disease-free survival was significantly longer in the sunitinib group.

Obesity Ups Risk for Secondary Primary Cancers in Men

Obesity Ups Risk for Secondary Primary Cancers in Men

Prediagnosis obesity is a risk factor for overall and individual secondary primary cancers.

Cabozantinib Superior as Front-Line Therapy for Advanced RCC

Cabozantinib Superior as Front-Line Therapy for Advanced RCC

Use of the drug is associated with significantly longer progression-free survival compared with suninitib in treatment-naïve patients.

Partial Nephrectomy Use Increasing

Partial Nephrectomy Use Increasing

Study of US veterans reveals, however, that the procedure is being used less in subgroups who might benefit the most.

TKI Dose Escalation After mRCC Progression Beneficial

TKI Dose Escalation After mRCC Progression Beneficial

In a small study, researchers observed a decrease in tumor burden and extended duration of therapy.

Immunotherapy Increasingly Used in Cancer Care

Immunotherapy Increasingly Used in Cancer Care

Immunotherapy treatments for patients with bladder cancer, head and neck cancer, Hodgkin's lymphoma, and kidney cancer, is useful against malignancy, according to Cancer Progress Report.

Data Support Biopsy Before Renal Cryo

Data Support Biopsy Before Renal Cryo

The recurrence group had significantly larger tumors than the no-recurrence group.

Higher Complication Rate Found With Open Partial Nephrectomy

Higher Complication Rate Found With Open Partial Nephrectomy

Open partial nephrectomy had a significantly higher rate of complications.

High BMI Predicts Improved RCC Patient Survival

High BMI Predicts Improved RCC Patient Survival

Paradoxical association could be related to an altered fatty acid pathway.

Slimmer People Have Lower Risks of Kidney, Other Cancers

Slimmer People Have Lower Risks of Kidney, Other Cancers

International committee finds slimmer individuals less likely to develop variety of malignancies.

Robotic, Open PN Similarly Effective for Endophytic Kidney Tumors

Robotic, Open PN Similarly Effective for Endophytic Kidney Tumors

Robotic surgery may offer some benefits, such as shorter hospital stay and less blood loss.

Kidney Cancer Risk Linked to Metalworking Fluids

Kidney Cancer Risk Linked to Metalworking Fluids

Mean exposure of 18.80 mg/m3 per year was associated with a significant 11% increased risk among white men.

Active Surveillance Possible Before Treatment in mRCC

Active Surveillance Possible Before Treatment in mRCC

Some metastatic RCC patients may safely undergo surveillance prior to starting systematic therapy.

Metabolic Factors Linked to RCC Treatment Resistance

Metabolic Factors Linked to RCC Treatment Resistance

Research results provide potential new targets for combination therapy regimens.

Aspirin Does Not Hike Kidney Surgery Bleeding Complications

Aspirin Does Not Hike Kidney Surgery Bleeding Complications

Study finds no increased risk of overall complications in patients undergoing robotic partial nephrectomy.

Chest X-Rays May Miss Pulmonary Metastases in T1a RCC Patients

Chest X-Rays May Miss Pulmonary Metastases in T1a RCC Patients

Findings in patients treated for T1a renal cell carcinoma followed with X-ray surveillance.

Smaller Renal Tumors Predict Longer Surgical Wait Times

Smaller Renal Tumors Predict Longer Surgical Wait Times

Patients whose surgical wait time was 3 months or more versus less than 3 months had 10-fold increased odds of having a smaller tumor.

Disseminated Cancer Increases Nephrectomy Complication Rate

Disseminated Cancer Increases Nephrectomy Complication Rate

Disseminated cancer at the time of radical nephrectomy is associated with 2-fold increased odds of major perioperative complications.

Laparoscopic Nephrectomy May Be Performed as Outpatient Surgery

Laparoscopic Nephrectomy May Be Performed as Outpatient Surgery

Most patients discharged home within first 6 hours after surgery; none readmitted.

Cabozantinib Shows Superiority in Treating Advanced mRCC

Cabozantinib Shows Superiority in Treating Advanced mRCC

The drug significantly improves overall and progression-free survival compared with everolimus, researchers report.

Early Tumor Shrinkage Predicts mRCC Treatment Outcomes

Early Tumor Shrinkage Predicts mRCC Treatment Outcomes

The optimal tumor shrinkage threshold for predicting overall and progression-free survival is 10%, researchers concluded.

Achieving 4 Lifestyle Standards May Reduce Cancer Mortality

Achieving 4 Lifestyle Standards May Reduce Cancer Mortality

Four key lifestyle factors include weight, exercise, no smoking, and limiting alcohol.

Leisure Activity Linked With Lower Risk of Several Cancers

Leisure Activity Linked With Lower Risk of Several Cancers

Findings for self-reported leisure-time physical activity of moderate to vigorous intensity.

Higher Cancer Risk in Dialysis Patients Confirmed

Higher Cancer Risk in Dialysis Patients Confirmed

The risk is most elevated among individuals aged 44 years or younger.

AKI After RCC Surgery On the Rise

AKI After RCC Surgery On the Rise

Nearly 6% of patients who underwent partial or radical nephrectomy between 1998 and 2010 developed AKI.

Survival Advantage Confirmed for Nephrectomy in mRCC

Survival Advantage Confirmed for Nephrectomy in mRCC

About 25% of patients who present with metastatic renal cancer will undergo nephrectomy after diagnosis.

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