Hyperuricemia

Gout Increases Chronic Kidney Disease Risk

Gout Increases Chronic Kidney Disease Risk

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In an observational UK study, chronic kidney disease stage 3 or higher was 78% more likely to develop in patients with vs without gout during a median follow-up of 6 years.

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol Linked to Reduced Risk for CKD Stage ≥3 in Gout

Allopurinol use is not associated with renal function decline among those with newly diagnosed gout.

High Gout Burden Found Among Solid Organ Transplant Recipients

High Gout Burden Found Among Solid Organ Transplant Recipients

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Study reveals an 11% prevalence of active gout among solid organ transplant recipients overall and a 13% prevalence among kidney transplant recipients.

High Uric Acid Raises Death Risk in CKD

High Uric Acid Raises Death Risk in CKD

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Patients with chronic kidney disease who have hyperuricemia have a 3-fold higher risk of all-cause mortality.

Febuxostat Increases CV Event Risk Only in Established CV Disease

Febuxostat Increases CV Event Risk Only in Established CV Disease

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Spanish study found no significant difference between febuxostat and allopurinol with respect to risk of new cardiovascular events among gout patients without prior cardiovascular disease.

Gout Outcomes Better With Nurse-Led Care

Gout Outcomes Better With Nurse-Led Care

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In a British study, nurse-led care emphasizing patient education and engagement significantly improved the proportion of gout sufferers who achieved target serum urate levels.

Obstructive Sleep Apnea May Increase Gout Risk

Obstructive Sleep Apnea May Increase Gout Risk

People with obstructive sleep apnea continued to be at higher risk of developing gout after the first year of obstructive sleep apnea diagnosis.

Clinical Gout-Related Benefits Not Seen With Lesinurad Combo Tx

Clinical Gout-Related Benefits Not Seen With Lesinurad Combo Tx

Although a combination of lesinurad 200 mg and xanthine oxidase inhibitor therapy was effective and well-tolerated among patients with gout, clinical gout-related benefits were not improved.

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

Ultrasound Can Reveal Renal Medulla Urate Deposits in Tophaceous Gout

Ultrasound examination may be used to detect crystal deposition in the renal medulla in patients with tophaceous gout.

Knee, Metatarsophalangeal Joint Exam May Improve Gout Diagnosis

Knee, Metatarsophalangeal Joint Exam May Improve Gout Diagnosis

Researchers evaluated the distribution of ultrasound features of lower-limb joints and the risk factors of tophus in patients with gout.

Gout Patients Have Lower Prevalence of Colorectal Cancer

Gout Patients Have Lower Prevalence of Colorectal Cancer

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The 10-year prevalence of colonoscopy-documented colorectal cancer was 0.8% among gout patients vs 3.7% among osteoarthritis patients.

Urate Levels Predict Long-Term Gout Risk

Urate Levels Predict Long-Term Gout Risk

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In a large Swedish study of middle-aged individuals, increments in baseline serum urate levels were associated with progressively increased risks of gout over a mean 28 years of follow-up.

Gout Associated With Increased Hearing Loss Risk in the Elderly

Gout Associated With Increased Hearing Loss Risk in the Elderly

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Hearing impairment is 44% more likely to develop in Medicare patients with vs without gout, a study of Medicare claims data shows.

Gout Risk Possibly Linked to Iron Intake

Gout Risk Possibly Linked to Iron Intake

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Elevated levels of serum ferritin, which stores excess iron, are positively associated with gout risk, investigators concluded.

Gout Associated With Increased Risk of Developing Erectile Dysfunction

Gout Associated With Increased Risk of Developing Erectile Dysfunction

Data show that gout is associated with an increased risk of developing erectile dysfunction.

Gout Increases Atrial Fibrillation Risk in the Elderly

Gout Increases Atrial Fibrillation Risk in the Elderly

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A study of Medicare patients found that atrial fibrillation was nearly twice as likely to develop in those with vs without gout.

Uric Acid Predicts AKI Risk After Cardiac Surgery

Uric Acid Predicts AKI Risk After Cardiac Surgery

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Serum uric acid levels above the median prior to cardiac surgery is independently associated with 5.5-fold increased odds of postoperative acute kidney injury.

Both High and  Low Uric Acid Levels Tied to Higher Mortality

Both High and Low Uric Acid Levels Tied to Higher Mortality

Association showed increased risk of all-cause, cardiovascular, and cancer death.

Medication Adherence Low in Gout Patients Initiating Allopurinol

Medication Adherence Low in Gout Patients Initiating Allopurinol

Medication adherence also remained low in patients who reinitiate treatment after a gap in therapy.

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

Development of Clinically Evident Gout: A Closer Look at Elevated Serum Urate Levels

Serum urate level is a strong predictor of incident gout, but only about half of patients with hyperuricemia develop clinically evident gout.

Emergency Department Gout Visits Rise Dramatically

Emergency Department Gout Visits Rise Dramatically

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US study documents a 27% increase in visits to emergency departments for a primary diagnosis of acute gout from 2006 to 2014.

Hyperuricemia Prevalence Increasing

Hyperuricemia Prevalence Increasing

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From 2006 to 2014 in Ireland, the prevalence of hyperuricemia increased from 19.7% to 25.0% among men and from 20.5% to 24.1% among women.

Mortality Risks Higher With Febuxostat vs Allopurinol

Mortality Risks Higher With Febuxostat vs Allopurinol

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All-cause and cardiovascular mortality risks were 22% and 34% higher among febuxostat-treated patients vs allopurinol recipients.

Kidney Failure, Death Tied With Elevated Uric Acid in CKD Patients

Kidney Failure, Death Tied With Elevated Uric Acid in CKD Patients

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In a study, CKD patients with high trajectories of serum uric acid had nearly triple the risk for ESRD and 4.5 times the risk for death.

High Uric Acid Ups Renal Failure Risk in Some CKD Patients

High Uric Acid Ups Renal Failure Risk in Some CKD Patients

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Among CKD patients with an eGFR of 45 mL/min/1.73 m2 or above, each 1 SD increase in baseline uric acid levels is independently associated with a 40% increased risk of kidney failure.

FDA Issues Safety Alert for Gout Medication

FDA Issues Safety Alert for Gout Medication

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Febuxostat may increase the risk for heart-related death.

Uric Acid-Lowering Therapy Helps Kidney, Heart

Uric Acid-Lowering Therapy Helps Kidney, Heart

Uric acid-lowering therapy might improve kidney outcomes, including kidney failure events, proteinuria, and the rate of change in eGFR, and seem to reduce the risk of cardiovascular events in adults with CKD.

Rapid Kidney Function Decline in Blacks Linked to Elevated Uric Acid

Rapid Kidney Function Decline in Blacks Linked to Elevated Uric Acid

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Each 1 standard deviation in baseline uric acid levels was associated with a significant 80% increased odds of rapid kidney function decline.

Metoprolol Increases Uric Acid, Risk of Gout

Metoprolol Increases Uric Acid, Risk of Gout

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In a study of African Americans with hypertension-related CKD, metoprolol, but neither ramipril nor amlodipine, increased serum uric acid levels.

Erectile Dysfunction Risk Higher in Gout Patients

Erectile Dysfunction Risk Higher in Gout Patients

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The risk for developing erectile dysfunction is 15% higher among men with than without gout.

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