Hyperuricemia News Archive

High Uric Acid Ups Renal Failure Risk in Some CKD Patients

High Uric Acid Ups Renal Failure Risk in Some CKD Patients

Among CKD patients with an eGFR of 45 mL/min/1.73 m2 or above, each 1 SD increase in baseline uric acid levels is independently associated with a 40% increased risk of kidney failure.

FDA Issues Safety Alert for Gout Medication

FDA Issues Safety Alert for Gout Medication

Febuxostat may increase the risk for heart-related death.

Uric Acid-Lowering Therapy Helps Kidney, Heart

Uric Acid-Lowering Therapy Helps Kidney, Heart

Uric acid-lowering therapy might improve kidney outcomes, including kidney failure events, proteinuria, and the rate of change in eGFR, and seem to reduce the risk of cardiovascular events in adults with CKD.

Rapid Kidney Function Decline in Blacks Linked to Elevated Uric Acid

Rapid Kidney Function Decline in Blacks Linked to Elevated Uric Acid

Each 1 standard deviation in baseline uric acid levels was associated with a significant 80% increased odds of rapid kidney function decline.

Metoprolol Increases Uric Acid, Risk of Gout

Metoprolol Increases Uric Acid, Risk of Gout

In a study of African Americans with hypertension-related CKD, metoprolol, but neither ramipril nor amlodipine, increased serum uric acid levels.

Erectile Dysfunction Risk Higher in Gout Patients

Erectile Dysfunction Risk Higher in Gout Patients

The risk for developing erectile dysfunction is 15% higher among men with than without gout.

Gout Patient Hospitalizations Soar

Gout Patient Hospitalizations Soar

All-cause hospitalizations in the US increased 410% from 1993 to 2014 among gout sufferers compared with 4.8% in the general population.

Gout Risk Is Lower Among Healthier Eaters

Gout Risk Is Lower Among Healthier Eaters

A DASH-style diet is associated with a reduced risk of gout, whereas a Western diet is associated with a higher risk.

Most US Gout Sufferers Not Taking Urate-Lowering Drugs

Most US Gout Sufferers Not Taking Urate-Lowering Drugs

Gout is uncontrolled in the majority of individuals with the condition, data show.

Women With Gout at Greater Risk for Hip Fracture

Women With Gout at Greater Risk for Hip Fracture

The multivariable-adjusted relative risk of hip fracture was 1.38 in women with history of gout.

Black Gout Sufferers Have Worse HRQoL

Black Gout Sufferers Have Worse HRQoL

Blacks had significantly higher median baseline serum urate levels compared to whites.

Allopurinol May Benefit The Kidneys

Allopurinol May Benefit The Kidneys

The allopurinol group had a significant 0.10 mg/dL lower final creatinine level than controls.

DASH Diet Lowers Uric Acid in Pre-, Early Hypertension

DASH Diet Lowers Uric Acid in Pre-, Early Hypertension

The DASH diet lowered serum uric acid, and this effect was greater among participants with hyperuricemia.

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Higher Uric Acid Levels in Critically Ill Patients Up AKI Risk

Odds of acute kidney injury increases by 29% with each 1 mg/dL increment in uric acid level at ICU admission.

Uric Acid-Lowering Benefit of Lesinurad Confirmed

Uric Acid-Lowering Benefit of Lesinurad Confirmed

Benefit of adding the uricosuric drug to a xanthine oxidase inhibitor persists for up to 2 years, extension study shows.

ACP Releases New Gout Guidelines

ACP Releases New Gout Guidelines

The guidelines recommend treatment strategies and state that evidence is insufficient to support therapy to lower uric acid to target levels.

New Oral Treatment for Hyperuricemia Tied to Gout

New Oral Treatment for Hyperuricemia Tied to Gout

Zurampic, a URAT1 inhibitor, can be combinated with a xanthine oxidase inhibitor to treat hyperuricemia tied to gout.

Uric Acid Threshold That Predicts Kidney Stone Formation Identified

Uric Acid Threshold That Predicts Kidney Stone Formation Identified

Serum uric acid levels of 10 mg/dL or higher are associated with an increased risk for nephrolithiasis.

Lesinurad Improves Uric Acid Lowering in Gout Sufferers

Lesinurad Improves Uric Acid Lowering in Gout Sufferers

Using the drug together with allopurinol helps more patients achieve target uric acid levels of less than 6 mg/dL.

DASH Diet May Protect Against Kidney Disease

DASH Diet May Protect Against Kidney Disease

In a study, CKD was 16% less likely to develop in low adherers to a DASH dietary pattern.

Gout Found to Increase Type 2 Diabetes Risk

Gout Found to Increase Type 2 Diabetes Risk

The effect of gout on type 2 diabetes risk was more profound in women than men.

Venous Thromboembolism Linked to High Uric Acid

Venous Thromboembolism Linked to High Uric Acid

Highest vs lowest uric acid levels associated with a 2-fold increased risk of VTE.

Higher Allopurinol Dose Protects Elderly From Renal Failure

Higher Allopurinol Dose Protects Elderly From Renal Failure

A higher allopurinol dose was protective against renal failure in elderly allopurinol recipients.

High Uric Acid Increases Risk of Non-Fatal Stroke in CKD Patients

High Uric Acid Increases Risk of Non-Fatal Stroke in CKD Patients

Odds of non-fatal stroke are 49% higher in patients in the fourth quartile of uric acid level versus those in the second quartile.

Most Gout Inadequately Controlled

Most Gout Inadequately Controlled

Patients with inadequately controlled gout experience lower quality of life and report worse functioning.

Uric Acid Levels Low in Adolescents With Type 1 Diabetes

Uric Acid Levels Low in Adolescents With Type 1 Diabetes

Unlike in adults, there is no association between uric acid, cardiorenal parameters.

Febuxostat May Slow Renal Decline in Hyperuricemic CKD Patients

Febuxostat May Slow Renal Decline in Hyperuricemic CKD Patients

Patients treated with the uric acid-lowering drug were less likely to experience a greater than 10% decline in eGFR than placebo recipients.

High Uric Acid Raises ESRD Risk

High Uric Acid Raises ESRD Risk

The highest vs. lowest quartile of serum uric acid is associated with a 3.4-fold increased risk of end-stage renal disease.

Researchers: View Gout as a Warning Sign

Researchers: View Gout as a Warning Sign

Gout is associated with an elevated risk of comorbid conditions, especially hypertension and alcohol abuse.

High Uric Acid Levels Up Death Risk in the Elderly

High Uric Acid Levels Up Death Risk in the Elderly

Highest vs. lowest quartile associated with a 17% increased risk.

High Uric Acid Levels Tied to Early Death in Seniors

High Uric Acid Levels Tied to Early Death in Seniors

Association strongest with cardiovascular mortality in the elderly.

Gout Increases Risk of Erectile Dysfunction

Gout Increases Risk of Erectile Dysfunction

Gout is associated with an elevated likelihood of both organic and psychogenic ED.

Risk Factors for CKD Progression ID'd

Risk Factors for CKD Progression ID'd

Proteinuria, hyperphosphatemia, anemia linked more rapid annual decline in eGFR.

Erectile Dysfunction Linked to Gout

Erectile Dysfunction Linked to Gout

Gout increased the risk of erectile dysfunction in men by 21%.

Diabetic Kidney Disease Linked to High Uric Acid

Diabetic Kidney Disease Linked to High Uric Acid

Increased uric acid levels were correlated with decreased HbA1c and increased prevalence of diabetic kidney disease, study finds.

Gout Patients Commonly Develop CKD and Stones

Gout Patients Commonly Develop CKD and Stones

Guidelines currently don't recognize gout as a risk factor for CKD and nephrolithiasis.

Study: CKD is a Gout Risk Factor

Study: CKD is a Gout Risk Factor

The incidence of gout among CKD patients was 6.82 per 1,000 persons per year compared to 2.43 for those without the disease.

Gout Flares More Likely During the Night

Gout Flares More Likely During the Night

The risk for gout flares was 236% higher overnight than in the day.

Many Gout Patients Undertreated

Many Gout Patients Undertreated

Although 87% of patients met the criteria for urate-lowering treatment within 5 years, only 30% were prescribed the recommended treatment.

Impaired Renal Function Linked to Higher Uric Acid Levels

Impaired Renal Function Linked to Higher Uric Acid Levels

Even levels in the normal range can be associated with an increased risk of renal insufficiency.

Blood in Semen Linked to High Uric Acid

Blood in Semen Linked to High Uric Acid

Researchers concluded that hyperuricemia is a probable cause of hemospermia.

Smoking Found to Cut Gout Risk

Smoking Found to Cut Gout Risk

Analysis found that cigarette smoking was associated with a 24% overall reduction in gout risk.

Gout Increases Risk of Diabetes

Gout Increases Risk of Diabetes

Women with this form of arthritis are more susceptible to diabetes, researchers say.

Gout Risk Linked to Body Mass Index

Gout Risk Linked to Body Mass Index

Each 5-unit increment in BMI is associated with a 55% increased relative risk of gout.

Allopurinol Offers No Cardiovascular Benefit

Allopurinol Offers No Cardiovascular Benefit

Allopurinol therapy is not associated with beneficial cardiovascular outcomes in gout patients.

Living Kidney Donors Are At Higher Gout Risk

Living Kidney Donors Are At Higher Gout Risk

In a study, donors were 60% more likely to be diagnosed with gout than matched healthy controls.

Weather Found to Affect Gout Attack Risk

Weather Found to Affect Gout Attack Risk

Likelihood of a recurrent gout attack is greater under conditions of high temperature and/or low relative humidity.

High Uric Acid May Hasten Dialysis Initiation

High Uric Acid May Hasten Dialysis Initiation

Renal function decline is not accelerated, however.

Homocysteine Levels Elevated in Gout Patients

Homocysteine Levels Elevated in Gout Patients

Korean study also revealed an inverse association between serum homocysteine levels and renal function.

Uric Acid May Predict Outcomes in Dialysis Patients

Uric Acid May Predict Outcomes in Dialysis Patients

An Israeli study shows that serum uric acid levels can be a clinically useful nutritional marker.

Uric Acid Lowering Has Renal Benefits

Patients with hyperuricemia who use urate-lowering therapies are less likely to experience renal function decline.

High Uric Acid Increases Hip Fracture Risk in Older Men

High Uric Acid Increases Hip Fracture Risk in Older Men

A level of 7 mg/dL or higher is associated with a 62% increased risk compared with lower levels.

High Uric Acid Raises Risk of Diabetes

High Uric Acid Raises Risk of Diabetes

Elevated levels of uric acid are associated with an increased likelihood of diabetes.

Erectile Dysfunction, Uric Acid Linked in CAD Patients

Erectile Dysfunction, Uric Acid Linked in CAD Patients

Patients with coronary artery disease are more likely to have ED if they have elevated uric acid levels.

High Uric Acid Raises Diabetes Risk

High Uric Acid Raises Diabetes Risk

After diabetes is diagnosed, however, uric acid levels fall, study finds.

High Uric Acid Level Linked to Coronary Stent Restenosis

High Uric Acid Level Linked to Coronary Stent Restenosis

Serum level before procedure is an independent predictor of stent restenosis.

Gout Runs in the Family

Gout Runs in the Family

Individuals with first-degree relatives affected by the condition are twice as likely as those in the general population to experienced gout.

Hyperuricemia May Have a Role in Hematospermia

Patients with hyperuricemia also had a high prevalence of lower urinary tract symptoms.

Uric Acid Ruled Out As Heart Disease Cause

Elevated uric acid levels are associated with increased risk of ischemic heart disease and blood pressure, but appear unlikely to cause these problems, a study found.

No Gout Relieve From Vitamin C

Patients with gout experienced no clinically significant urate-lowering effects from an 8-week course of a modest dosage of vitamin C.

Urate Lowering May Have Renal Benefits in CKD Patients

Systemic review suggests allopurinol can significantly improve estimated glomerular filtration rates.

Allopurinol-Induced AEs Linked to Colchicine, Statin Use

Adverse events included skin rash, gastrointestinal problems, and allopurinol hypersensitivity syndrome.

Gout Discovered in 30% of Patients with Severe CKD

Gout prevalence is higher among patients with lower average estimated glomerular filtration rates or higher levels of albuminuria

Hypertension Increases Gout Risk

The two are linked regardless of gender, race, and obesity.

Study: Cherries Lower Gout Attack Risk

An consumption over a two-year period found to decrease likelihood of a gout attack by 35%.

Study: Gout Affects 4% of Americans

Data from 5,707 participants of the National Health and Nutrition Examination Survey (NHANES) 2007-2008 show that gout now affects 4% of Americans (8.3 million individuals), and hyperuricemia, 21% (43.3 million).

High Uric Acid Raises CKD Risk, Study Finds

PARIS—High levels of uric acid are associated with an increased risk of chronic kidney disease (CKD), especially among hypertensive individuals.

BP, Uric Acid Linked in Adolescents

Elevated blood pressure is twice as likely in those with a serum uric acid level of 5 mg/dL or higher

Renal Cysts More Common in Gout Patients

Gout patients have an increased prevalence of simple renal cysts, and these cysts are associated with a decreased likelihood of kidney stone disease, according to Brazilian investigators.

Gout Prevalence High in CKD Patients

PHILADELPHIA—Patients with chronic kidney disease (CKD) have a relatively high prevalence of gout compared with the general population, according to data presented at Kidney Week 2011.

Renal Disease, Diabetes Linked to Uric Acid

CHICAGO—Uncontrolled serum uric acid in patients with gout is associated with an increased risk of developing kidney disease and diabetes, according to the findings of two studies presented at the American College of Rheumatology annual meeting.

High Uric Acid Lowers Death Risk in Hemodialysis Patients

High uric acid concentrations are associated with lower all-cause and cardiovascular mortality among hemodialysis (HD) patients, according to an international study.

High Uric Acid Predicts Albuminuria

VANCOUVER, B.C.—Elevated serum uric acid levels strongly predict development of albuminuria in patients with chronic kidney disease (CKD), according to researchers in Romania.

Erectile Dysfunction Linked to High Uric Acid

WASHINGTON, D.C.—Elevated serum uric acid levels may be a marker for an increased risk of erectile dysfunction (ED), Iranian researchers reported at the American Urological Association 2011 annual meeting.

Allopurinol Can Be Used Safely in Renal Transplant Patients on Azathioprine

VANCOUVER, B.C.—Allopurinol can be prescribed safely to treat recurrent gout in renal transplant recipients who are receiving azathioprine, British researchers reported.

FDA Takes On Unapproved Single-Ingredient Colchicine

The FDA has ordered a halt to the marketing of unapproved single-ingredient oral colchicine, a medication commonly used for the daily prevention of gout, to treat acute gout flare-ups, and for the treatment of familial Mediterranean fever.

Drug for Chronic Refractory Gout Approved

Savient Pharmaceuticals, Inc., of East Brunswick, N.J., has received FDA clearance to market Krystexxa (pegloticase) as a treatment for chronic gout in adult patients refractory to conventional treatment.

Uric Acid May Have a Role in CKD Development

Higher serum uric acid (SUA) levels may independently contribute to the development of CKD, data suggest.

Gout Drug Has Cardiac Benefit

MUNICH, GERMANY—Allopurinol, a drug long used to treat gout, can cause regression of left ventricular hypertrophy (LVH) and improvement of endothelial dysfunction in CKD patients, a study found.

Gout Drug Helps CKD Patients

Allopurinol, a drug used to treat gout, may slow progression of kidney disease in CKD patients, according to new findings scheduled to be published in an upcoming issue of the Clinical Journal of the American Society of Nephrology.

Colchicine Formulation Cleared for Preventing Gout Flares

Colcrys, a new colchicine formulation, has received marketing clearance for the prevention of gout flares.

Panel Recommends Approval of Drug for Refractory Gout

The FDA's Arthritis Drugs Advisory Committee has recommended that Krystexxa (pegloticase) be approved for treating refractory chronic gout.

Elevated Uric Acid Hikes Mortality in CKD Patients

Hyperuricemia increases the risk of death from any cause and from cardiovascular disease (CVD) in patients with CKD stages 3 to 4, according to a report in the American Journal of Kidney Diseases (2009; published online ahead of print).

New Drug Cleared For Gout Patients

A new oral medication that reduces serum uric acid levels has received FDA approval for treating hyperuricemia in patients with gout.

Data Support Prednisolone Use For Gout

A short course of a corticosteroid could supplant nonsteroidal anti-inflammatory drugs (NSAIDs) as the medication of choice to treat gout, Dutch researchers suggest.

Uric Acid Stones Linked to Arteriosclerotic Diseases

ORLANDO, Fla.—Patients with metabolic disorders are more likely to develop uric acid stones than other types, and arteriosclerotic diseases and hyperuricemia strongly predict the presence of these stones, researchers reported here at the American Urological Association annual meeting.

Hyperuricemia Linked to CKD in African Americans

Hyperuricemia may be strongly associated with CKD in African Americans.

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