(HealthDay News) — Uncomplicated urinary tract infections (uUTIs) pose a substantial burden on US women, according to a study published online in PLOS ONE.

Jeffrey Thompson, PhD, from Cerner Enviza in Malvern, Pennsylvania, and colleagues assessed the impact of uUTIs from the patient perspective. The analysis included data from 375 US women who self-reported a uUTI in the prior 60 days and were treated with one or more oral antibiotic.

The researchers found that impaired activities included sexual intercourse (66.9%), sleep (60.8%), and exercise (52.3%). Compared with a matched control population, health-related quality of life (HRQoL) was worse, as measured with the physical component score, the mental component score, and health utility index. Further, Work Productivity and Activity Impairment assessments were worse for the uUTI cohort versus controls. For participants receiving 2 or more antibiotics, adjusted direct costs were significantly higher than for women receiving 1 antibiotic ($2090 versus $776). Increased activity impairment, worse HRQoL, and higher costs were seen for recurrent uUTI versus nonrecurrent uUTI.

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“While uUTIs are common, their impact on patients should not be underestimated; appropriate treatment is crucial in preventing adverse impacts on quality-of-life and health care resource utilization,” conclude the authors.

Two authors disclosed employment histories with Cerner Enviza, which received funding from GlaxoSmithKline to conduct this study. Three authors are employees of GlaxoSmithKline.

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