Endometrial cancer increases a woman’s risk for lower urinary tract infection (UTI), kidney failure, and other urinary problems, according to a recent study.

An analysis of 265,605 women aged 66 years or older showed that women diagnosed with endometrial cancer had a significant 2.4-, 2.3-, and 1.9-fold increased risk for lower UTI, kidney failure, and chronic kidney disease (CKD), respectively, compared with women who did not have a history of any cancer, Chelsea Anderson, PhD, MPH, of the Gillings School of Global Public Health at the University of North Carolina in Chapel Hill, and colleagues reported in Cancer Epidemiology, Biomarkers & Prevention. They also had a significant 2.2-fold increased risk for urinary stones.

“Results of the current study suggest that older women with endometrial cancer have a higher risk of several urinary outcomes than similarly aged women without a cancer history,” the authors wrote. “Timely identification and treatment of these conditions, especially among those with preexisting risk factors and those treated with chemotherapy and/or radiation, may be an important part of ongoing survivorship care after endometrial cancer.”

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The study population, identified using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database (2004-2017), compared 44,386 women diagnosed with endometrial cancer with a control group of 221,219 women without a cancer history matched by age, race or ethnicity, and state of residence.

Among women with endometrial cancer, the risk of most urinary outcomes tended to be higher among women who were older at cancer diagnosis, according to the investigators. For example, compared with women aged 66-69 years, those aged 70-74, 75-79, 80-84, and 85 years or older had an approximately 1.1-, 1.3-, 1.4-, and 1.5-fold increased risk for lower UTI, respectively, and 1.2-, 1.5-, 1.8-, and 2.1-fold increased risk for CKD, respectively, Dr Anderson’s team reported.

The increased risk of some urinary problems among women with endometrial cancer varied by race or ethnicity. For example, compared with White women, Black women had a 1.6- and 1.7-fold higher risk for CKD and kidney failure, respectively, and Hispanic women had a 1.2-fold higher risk for lower UTIs.


Anderson C, Olshan AF, Park J, et al. Adverse urinary system diagnoses among older women with endometrial cancer. Cancer Epidemiol Biomarkers Prev. Published online May 11, 2022. doi:10.1158/1055-9965.EPI-22-0236