Urinary Tract Infections (UTI)

Investigational Oral Carbapenem Antibiotic Gets Fast-Tracked for cUTI, Acute Pyelonephritis

Publish Date April 5, 2019

Spero Therapeutics announced that the Food and Drug Administration (FDA) has granted Fast Track designation for SPR994 (tebipenem pivoxil hydrobromide) for the treatment of complicated urinary tract infections (cUTI) and acute pyelonephritis (AP)

Guidelines Developed for Polymyxin Antibiotic Use

Publish Date March 15, 2019

Polymyxin B recommended for routine use in invasive infections; colistin preferred for lower UTI

Fosfomycin Promising for Chronic Bacterial Prostatitis

Publish Date February 27, 2019

Findings from a small study suggest it could be an effective, safe, and attractive alternative to fluoroquinolones, bacterial resistance to which is becoming increasingly prevalent.

Study Supports Once-Daily Plazomicin Use for Complicated UTIs

Publish Date February 22, 2019

Plazomicin is superior to meropenem in treating complicated UTIs due Enterobacteriaceae not susceptible to aminoglycosides.

Machine Learning Methods Can Detect UTI in Dementia Patients

Publish Date January 29, 2019

Research team used novel algorithms to ID early symptoms of health declines in dementia patients.

SGLT2 Inhibitors and Urinary Tract Infections: What’s the Link?

Publish Date December 19, 2018

For this study, the authors identified randomized controlled trials (RCTs) that compared SGLT2 inhibitors with placebo, no treatment, or another antidiabetic agent and reported on UTI outcome.

Abx-Resistant Enterobacteriaceae Tied to Clinical Failure in UTI

Publish Date November 8, 2018

Poor clinical outcomes linked to extended spectrum cephalosporin-resistant Enterobacteriaceae.

Fluoroquinolones Tied to Increased Risk for Arrhythmia, CV Mortality

Publish Date November 2, 2018

To investigate the risk of cardiovascular adverse effects associated with this antibiotic class, researchers conducted a systematic review, meta-analysis, and network meta-analysis using studies identified through a search of MEDLINE, EMBASE, and the Cochrane Library.

In Complicated UTI, Cefiderocol Noninferior to Imipenem-Cilastin

Publish Date October 31, 2018

Results from phase 2 study in patients with multidrug-resistant Gram-negative uropathogens.

UTI Risk After Urogynecologic Surgery Linked to Bladder Microbiome

Publish Date October 3, 2018

Depletion of Lactobacillus iners in the bladder appears to increase the risk of urinary tract infection following urogynecologic surgery, study finds.