Urethral bulking therapy is a valuable treatment option for women with severe stress urinary incontinence (SUI) who have undergone pelvic radiotherapy for gynecologic malignancies, researchers concluded.

Jan Krhut, MD, of University Hospital, Ostrava, Czech Republic, and colleagues enrolled 46 women with severe SUI in a prospective, multicenter trial and divided them into 2 groups: group A included 24 patients who had previous pelvic radiotherapy for gynecologic malignancies and group B included 22 patients without previous pelvic radiotherapy. All patients were treated with a transurethral injection of a bulking solution. The average follow-up was 12.4 months.

Complete continence was achieved in 25% and 36.4% of groups A and B, respectively, according to results published online in the International Urogynecology Journal. The investigators observed significantly decreased urine leakage in both groups. The total scores on the International Consultation on Incontinence Questionnaire decreased significantly by 5.2 and 6.36 in groups A and B, respectively. The scores on the Total Patient Perception of Bladder Condition questionnaire decreased significantly by 1.54 and 2.59, respectively.

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The researchers reported observing no clinically significant changes in urodynamic parameters and no severe adverse events.