Nivolumab treatment for patients who have undergone radical surgery for high-risk muscle-invasive urothelial carcinoma improves their disease-free survival compared with placebo, a study shows.
Compared with no ureteroscopy or percutaneous biopsy, ureteroscopic biopsy in patients with upper tract urothelial carcinoma was significantly associated with a 40% increased risk for intravesical recurrence of disease.
In current urological practice, clinicians decide whether to place a ureteral stent or nephrostomy, but evidence-based treatment guidance is needed.
Patients with metastatic urothelial carcinoma have significantly longer overall survival when treated with a combination of radiotherapy and chemotherapy compared with chemotherapy alone, a study found.
The presence of bone metastases is associated with shorter survival among patients who received single-agent immunotherapy for metastatic urothelial carcinoma.
A study of patients with metastatic upper tract urothelial carcinoma demonstrated that those who underwent cytoreductive surgery after chemotherapy had significantly improved survival compared with those who received chemotherapy alone.
Patients who receive treatment with immune checkpoint inhibitors for advanced renal cell carcinoma and urothelial carcinoma are more likely to experience disease progression and death if they have liver metastases, a study found.
In patients with high-risk tumors, those treated with segmental ureterectomy did not have worse overall survival compared with those who underwent radical nephroureterectomy.
As current guidelines only include a weak recommendation to offer perioperative chemotherapy to patients with muscle-invasive upper tract urothelial carcinoma, a new meta-analysis including evidence up to February 2020 provides potentially useful information.
Survival was significantly improved in patients with greater disease burden.