In patients with high-risk tumors, those treated with segmental ureterectomy did not have worse overall survival compared with those who underwent radical nephroureterectomy.
As current guidelines only include a weak recommendation to offer perioperative chemotherapy to patients with muscle-invasive upper tract urothelial carcinoma, a new meta-analysis including evidence up to February 2020 provides potentially useful information.
The 2020 update highlights the importance of accurate diagnosis of upper tract urothelial carcinoma, risk stratification, close follow-up of patients receiving kidney-sparing management, and other key aspects of care.
The grade-to-grade match between URS biopsy and final pathology was 66% for low-grade and 97% for high-grade tumors , according to a recent systematic review and meta-analysis.
A study of 13,438 patients with upper tract urothelial carcinoma in The Netherlands found that the incidence of the cancer increased significantly from 1993 to 2017, with no improvement in survival except for those with metastatic disease.