A team of investigators from the University of Texas MD Anderson Cancer Center assessed whether a relationship exists between hepatitis C virus infection and common genitourinary cancers, such as kidney and prostate cancer.
Template-based lymph node dissection in patients with upper tract urothelial carcinoma could facilitate better local disease control by eliminating micrometastasis, according to investigators.
Investigators performed a literature review to better understand how delays in treatment might affect clinical outcomes in urologic cancer patients, including the risk of upstaging, recurrence, and mortality.
A study found no survival differences between high-grade UTUC patients who at the time of radical nephroureterectomy achieved low-grade disease following neoadjuvant chemotherapy and those who had inherently low-stage disease and did not receive chemotherapy.
Upper tract urothelial cancer (UTUC) represents approximately 5%-10% of all urothelial cancers, although the incidence is increasing. Modifiable risk factors include exposure to toxins such as tobacco smoke, industrial toxins (including aromatic hydrocarbons, coal, coke, chlorinated solvents, and tars), arsenic, the analgesic phenacetin, and aristolochic acid. Produced by plants of the genus Aristolochia, aristolochic acid…
59% of patients had complete response at 4 to 6 weeks after initial therapy.
Patients with high-grade upper tract urothelial carcinoma who respond to neoadjuvant chemotherapy have a reduced risk of death following surgery compared with those who receive adjuvant chemotherapy, a study found.
The Food and Drug Administration (FDA) has granted expedited approval of Jelmyto (mitomycin for pyelocalyceal solution; UroGen Pharma) for the treatment of adult patients with low-grade upper tract urothelial cancer (LG-UTUC). The approval was based on data from the ongoing open-label, single-arm, phase 3 OLYMPUS study that assessed the efficacy of Jelmyto in 71 adults…
In a study, patients who had upper tract urothelial carcinoma with multifocal tumors had a 40% higher risk for urinary bladder recurrence than those with single tumors.
Neoadjuvant and adjuvant chemotherapy for patients undergoing nephroureterectomy for upper tract urothelial carcinoma are associated with decreased risks of metastasis and cancer-specific mortality, a meta-analysis showed.