Some AS Patients Eligible for Relaxed Prostate Biopsy Schedules

HealthDay News — Certain patients on active surveillance for prostate cancer may be eligible for less intensive surveillance, according to a study published in The Journal of Urology.

Evan Kovac, MD, from the Cleveland Clinic, and colleagues identified 300 men on active surveillance from a prospective database; the men had undergone initial surveillance prostate biopsy, with or without confirmatory biopsy, within one year of diagnosis. 87% were classified as having National Comprehensive Cancer Network very-low-risk or low-risk disease at diagnosis. The presence of 50% or more positive cores and/or surveillance prostate biopsy Gleason score upgrading was used to define disease reclassification on active surveillance.

The researchers found that 16 and 6% of patients had type I and II reclassification, respectively, at the time of initial surveillance prostate biopsy. The rates of type I and type II reclassification at initial surveillance prostate biopsy were reduced for those who underwent confirmatory biopsy (9 vs 23% [P = 0.001] and 3 vs 9% [P = 0.01], respectively). The 2-year rates of subsequent type I and II reclassification were 17 and 3%, respectively, for the 251 patients without disease reclassification at initial surveillance prostate biopsy.

“Patients on active surveillance with stable disease at the time of initial surveillance prostate biopsy may be appropriate candidates for less intensive surveillance prostate biopsy schedules,” the authors write.

One author disclosed financial ties to Cook and Healthtronics.

Reference

1. Kovac E, Lieser G, Elshafei A, et al. Outcomes of Active Surveillance after Initial Surveillance Prostate Biopsy. J Urol. 2017 Jan;197(1):84-89. doi: 10.1016/j.juro.2016.07.072